Year 2023 / Volume 115 / Number 5
Letter
The enigmatic triad, a clinical challenge

276-277

DOI: 10.17235/reed.2022.9212/2022

María Lourdes Ruiz Rebollo, Concepción García, César Alberto Berrocal de la Fuente, Borja Toribio Calvo,

Abstract
The concomitant occurrence of diabetic ketoacidosis (DKA), hypertriglyceridemia (HTG) and acute pancreatitis (AP) was first described by Nair et al. as “The Enigmatic Triad”, because the causal factor of AP is still not fully established. We recently attended a patient with this triad.
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References
1.- Nair S, Pitchumoni C, Diabetic ketoacidosis, hyperlipidemia, and acute pancreatitis: the enigmatic triangle. Am J Gastroenterol. 1997; 92:1560–1561.
2.- Dhatariya KK, Glaser NS, Codner E, Diabetic ketoacidosis. Nature reviews (2020) 6:40 doi.org/10.1038/s41572-020-0165-1
3.- Rawla P, Sunkara T, Thandra K C, Hypertriglyceridemia-induced pancreatitis: updated review of current treatment and preventive strategies. Clin J Gastroenterol (2018) 11:441–448
DOI: 10.1007/s12328-018-0881-1
4.- Simons-Linares CR, Jang S, Sanaka M, et al. The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. How does it affect mortality and morbidity?: a 10-year analysis of the National Inpatient Sample. Medicine (Baltimore) 2019; 98: e14378
DOI: 10.1097/MD.0000000000014378
5.- Morare N, Man DP, Herbst JP, et al Enigmatic Triad: Concomitant Hypertriglyceridemia, Diabetic Ketoacidosis, and Acute Pancreatitis. Pancreas 2022; 51(1): e3-e4. doi: 10.1097/MPA.0000000000001968
DOI: 10.1097/MPA.0000000000001968
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Ruiz Rebollo M, García C, Berrocal de la Fuente C, Toribio Calvo B. The enigmatic triad, a clinical challenge. 9212/2022


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Publication history

Received: 18/09/2022

Accepted: 25/09/2022

Online First: 07/10/2022

Published: 05/05/2023

Article Online First time: 19 days

Article editing time: 229 days


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