Year 2006 / Volume 98 / Number 4
Original
A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding: a prospective randomized trial

pp. 249-254

J. M. Palazón, J. Such, J. Sánchez-Payá, L. Company, E. de Madaria, L. Sempere, J. Martínez, P. Zapater, S. Pascual, F. Carnicer and M. Pérez-Mateo

Abstract
Background: the association of somatostatin (SMT) with endoscopic therapy in patients with cirrhosis and variceal bleeding significantly improves the control of the bleeding episode, and hemodynamic data have shown that a dosage of 500 µg/h allows a more marked reduction of portal pressure versus the usual dosage of 250 µg/h.
Aim: to assess if the 500 µg/h dosage is associated with an improved outcome.

Methods: sixty-two patients with variceal bleeding were included in the study. Patients were randomized to receive the usual dosage of SMT (group I: 250 µg/h), or a double dosage (group II:
500 µg/h), together with emergency endoscopic sclerotherapy.

Results: the control of the bleeding episode was similar in both groups of patients. Early rebleeding was less frequent in patients receiving double vs. single dosage of SMT (p = 0.06). When
considering patients with advanced liver disease (Child-Pugh B or C) early rebleeding was significantly less frequent in patients receiving
the 500 µg/h dose of SMT (39 vs. 13%, p = 0.03).

Conclusions: the perfusion of higher doses of SMT (500 µg/h) in association with emergency sclerotherapy in patients with cirrhosis and esophageal hemorrhage significantly decreases
the rate of early rebleeding in patients with more advanced stages of liver disease.
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J. M. Palazón, J. Such, J. Sánchez-Payá, L. Company, E. de Madaria, L. Sempere, J. Martínez, P. Zapater, S. Pascual, F. Carnicer and M. Pérez-Mateo. A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding: a prospective randomized trial. 249-254


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