Year 2023 / Volume 115 / Number 10
Original
Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease

553-558

DOI: 10.17235/reed.2023.9536/2023

Patricia Latorre Añó, Jorge Torrente Sánchez, Amparo Almudena Pérez Ibañez, Jose María Tenias Burillo, Nadia Paloma Moreno Sánchez, Antonio López-Serrano, Eduardo Moreno Osset, Julián Murado Pardo, José María Paredes,

Abstract
Aim: endoscopy identifies inflammatory activity, however, it is an unpleasant test and is not always accessible. The aim of the study was to compare the usefulness of quantitative fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD). Methods: cross-sectional prospective observational study. The stool samples were collected within three days before starting the preparation for the colonoscopy. We used the Mayo index for ulcerative colitis (UC) and the simplified endoscopic index for Crohn’s disease (CD). Mucosal healing (MH) was defined as the score 0 points in each of the endoscopic indices. Results: eighty-four patients were included, 40 (47.6 %) with UC. In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/MH on endoscopy, with no statistically significant differences between the two receiver-operating characteristic (ROC) curves. Both tests improved their diagnostic performance when assessing patients with UC; the Spearman correlations between FIT and FC and endoscopic inflammatory activity were r = 0.6 (p = 0.0001) and r = 0.7 (p = 0.0001), respectively. In Crohn’s disease, the diagnostic utility of both tests was lower. Conclusions: FIT is an alternative to monitor endoscopic activity among ulcerative colitis patients. In Crohn’s disease, more studies are needed to determine the role of fecal biomarkers.
Lay Summary
Estudio observacional prospectivo que tiene como objetivo comparar la utilidad del test de sangre oculta en heces inmunoquímico (TSOH-i) vs la calprotectina fecal (CF) para determinar la actividad endoscópica en pacientes con enfermedad inflamatoria intestinal (EII). En pacientes con EII, ambos biomarcadores fecales muestran una correlación significativa con la presencia de actividad inflamatoria/curación mucosa, sin diferencias estadísticamente significativas. El rendimiento diagnóstico mejora cuando se valoran los pacientes con colitis ulcerosa (CU) y empeora en la enfermedad de Crohn (EC). Se concluye que el TSOH-I es una alternativa a la CF para monitorizar la actividad endoscópica en pacientes con CU.
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References
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Latorre Añó P, Torrente Sánchez J, Pérez Ibañez A, Tenias Burillo J, Moreno Sánchez N, López-Serrano A, et all. Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease. 9536/2023


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Publication history

Received: 16/02/2023

Accepted: 19/04/2023

Online First: 28/04/2023

Published: 09/10/2023

Article revision time: 54 days

Article Online First time: 71 days

Article editing time: 235 days


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