Year 2022 / Volume 114 / Number 10
Original
Metabolic syndrome before liver transplantation: does it have an impact on post liver transplantation outcome?

586-591

DOI: 10.17235/reed.2022.8384/2021

Julia Herreras López, Lorena Puchades, Tommaso Di Maira, Antonio José Cañada, Javier Maupoey, Rafael López-Andújar, Martín Prieto Castillo, Marina Berenguer Haym, Victoria Aguilera,

Abstract
Introduction: Metabolic syndrome (MS) and cardiovascular risk factors are common in liver transplant (LT) candidates and recipients. Cardiovascular events and de novo tumors are increasingly common causes of mortality in liver transplant recipients. The aim of this study were (i) assess the prevalence of MS in LT recipients and its growth over the years and (ii) determine if the presence of MS pre-LT is associated with a higher risk of post-LT cardiovascular events (CVE), de novo tumors or early and late survival. Patients and methods: A retrospective study was performed that included LT recipients from January 2012 to December 2017. Baseline features (MS before LT and at 1year post-LT) and outcomes (CVE, de novo tumors and survival) were recorded. Results: 483 recipients were included, MS was present in 20% of pre-LT with an increasing prevalence over time, from 16% in 2012 to 34% in 2017 (p=0.025). One-year post-LT, an additional 12% had developed de novo MS. At a median of 56-months follow-up, 13% developed a CVE and 9% a de novo tumor. One and 5-yr survival rates were 91% and 83% in those with pre-LT MS and 93% and 85% in those without (p=0.94).The presence of MS before LT was independently associated with a higher risk of post-LT CVE (HR: 2.66 IC (95%): 1.6-4.4 p< 0.001), but not with de novo tumors (p=0.94) nor early and late survival (p=0.58 and p=0.87). Conclusion: Pre-LT MS is increasing among LT candidates and is associated with a higher risk of post-LT morbidity CVE yet without affecting mortality.  
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Herreras López J, Puchades L, Di Maira T, Cañada A, Maupoey J, López-Andújar R, et all. Metabolic syndrome before liver transplantation: does it have an impact on post liver transplantation outcome?. 8384/2021


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Publication history

Received: 10/10/2021

Accepted: 18/01/2022

Online First: 20/01/2022

Published: 07/10/2022

Article revision time: 91 days

Article Online First time: 102 days

Article editing time: 362 days


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