Año 2021 / Volumen 113 / Número 2
Revisión
Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis

125-135

DOI: 10.17235/reed.2020.7397/2020

Javier Ampuero, Yolanda Sánchez, María Rosario García-Lozano, Douglas Maya-Miles, Manuel Romero Gómez,

Resumen
Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact of baseline liver function (aspartate aminotransferase [AST], alanine aminotransferase [ALT], bilirubin) on COVID-19-related outcomes, including mortality, intensive care unit (ICU) admissions, and non-fatal severe complications. Methods: after a systematic review of the relevant studies the odds ratio (OR), mean difference, sensitivity, specificity, and both positive and negative likelihood ratios were calculated for the prediction of relevant COVID-19 outcomes by performing a meta-analysis using fixed and random effects models. A Fagan nomogram was used to assess clinical usefulness. Heterogeneity was explored by sensitivity analysis and univariate meta-regression. Results: twenty-six studies were included (22 studies and 5,271 patients for AST, 20 studies and 5,440 subjects for ALT, and nine studies and 3,542 patients for bilirubin). The outcomes assessed by these studies were: survival (n = 8), ICU admission (n = 4), and non-fatal severe complications (n = 16). AST > upper limit of normal (ULN) (OR: 3.10 [95 % CI, 2.61-3.68]), ALT > ULN (OR: 2.15 [95 % CI, 1.43-3.23]), and bilirubin > ULN (OR: 2.78 [95 % CI, 1.88-4.13]) were associated with an increased prevalence of severe complications with a specificity of 78 %, 77 %, and 94 %, respectively. The mean difference between mild and severe COVID-19 was 10.7 U/l (95 % CI, 5.8-15.6) for AST, 8 U/l (95 % CI, 1.0-15) for ALT, and 0.3 mg/dl (95 % CI, 0.16-0.45) for bilirubin. Conclusions: patients showing liver injury had a significantly higher risk of developing severe COVID-19 as compared to those with normal liver function tests at admission. We should include the assessment of AST, ALT, and total bilirubin (TB) routinely in the workup of patients affected by SARS-CoV-2 in order to predict those at risk of developing COVID-19-related outcomes.
Share Button
Nuevo comentario
Comentarios
No hay comentarios para este artículo.
Bibliografía
1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733.
2. Crespo J, Iglesias-Garcia J, Hinojosa J, et al. COVID-19 and the Digestive System: Protection and Management During the SARS-CoV-2 Pandemic. Rev. Esp. Enferm. Dig. 2020;112
3. Liu PP, Blet A, Smyth D, et al. The Science Underlying COVID-19: Implications for the Cardiovascular System. Circulation 2020;
4. Hussain A, Bhowmik B, Cristina do Vale Moreira N. COVID-19 and Diabetes: Knowledge in Progress. Diabetes Res. Clin. Pract. 2020;108142.
5. Wu P, Duan F, Luo C, et al. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;
6. Su C-J, Lee C-H. Viral exanthem in COVID-19, a clinical enigma with biological significance. J. Eur. Acad. Dermatol. Venereol. 2020;
7. Xiong M, Liang X, Wei Y. Changes in Blood Coagulation in Patients with Severe Coronavirus Disease 2019 (COVID‐19): a Meta‐Analysis. Br. J. Haematol. 2020;bjh.16725.
8. Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. Gastroenterology 2020;
9. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395:1033–1034.
10. Zhu J, Ji P, Pang J, et al. Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis. J. Med. Virol. 2020;
11. Henry BM, Oliveira MHS de, Benoit S, et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin. Chem. Lab. Med. 2020;
12. Cai Q, Huang D, Yu H, et al. Characteristics of Liver Tests in COVID-19 Patients. J. Hepatol. 2020;
13. Ji D, Qin E, Xu J, et al. Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study. J. Hepatol. 2020;
14. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann. Intern. Med. 2009;151:264–269.
15. Hayden JA, Côté P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann. Intern. Med. 2006;144:427–437.
16. Higgins JPT, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. Br. Med. J. 2003;327:557–560.
17. Copas JB, Shi JQ. A sensitivity analysis for publication bias in systematic reviews. Stat. Methods Med. Res. 2001;10:251–265.
18. Petitti DB. Approaches to heterogeneity in meta-analysis. Stat. Med. 2001;20:3625–33.
19. Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020;
20. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;
21. Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020;
22. Bangash MN, Patel J, Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol. Hepatol. 2020;
23. Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol. Hepatol. 2020;5:428–430.
24. Chai X, Hu L, Zhang Y, et al. Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection. bioRxiv 2020;2020.02.03.931766.
25. Feng G, Zheng KI, Yan Q-Q, et al. COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. J. Clin. Transl. Hepatol. 2020;8:18–24.
26. Boeckmans J, Rodrigues RM, Demuyser T, et al. COVID-19 and drug-induced liver injury: a problem of plenty or a petty point? Arch. Toxicol. 2020;
27. Wynants L, Calster B Van, Bonten MMJ, et al. Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. BMJ 2020;369:m1328.
28. Munster VJ, Koopmans M, Doremalen N van, et al. A novel coronavirus emerging in China - Key questions for impact assessment. N. Engl. J. Med. 2020;382:692–694.
29. Fan Z, Chen L, Li J, et al. Clinical Features of COVID-19-Related Liver Damage. Clin. Gastroenterol. Hepatol. 2020;
30. Xie H, Zhao J, Lian N, et al. Clinical characteristics of Non-ICU hospitalized patients with coronavirus disease 2019 and liver injury:A Retrospective study. Liver Int. 2020;
31. Sun D, Li H, Lu X-X, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J. Pediatr. 2020;
32. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507–513.
33. Lippi G, Oliveira MHS de, Henry BM. Chronic liver disease is not associated with severity or mortality in Coronavirus disease 2019 (COVID-19). Eur. J. Gastroenterol. Hepatol. 2020;1.
34. Fu L, Wang B, Yuan T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. J. Infect. 2020;
35. Gong J, Ou J, Qiu X, et al. A Tool to Early Predict Severe Corona Virus Disease 2019 (COVID-19) : A Multicenter Study using the Risk Nomogram in Wuhan and Guangdong, China. Clin. Infect. Dis. 2020;
36. Zhang J, Wang X, Jia X, et al. Risk factors for disease severity, unimprovement, and mortality of COVID-19 patients in Wuhan, China. Clin. Microbiol. Infect. 2020;
37. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020;
38. Li Y-K, Peng S, Li L-Q, et al. Clinical and Transmission Characteristics of Covid-19 — A Retrospective Study of 25 Cases from a Single Thoracic Surgery Department. Curr. Med. Sci. 2020;
39. Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020;368:m1091.
40. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;
41. Cao J, Tu W-J, Cheng W, et al. Clinical Features and Short-term Outcomes of 102 Patients with Corona Virus Disease 2019 in Wuhan, China. Clin. Infect. Dis. 2020;
42. Guan W, Ni Z, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med. 2020;
43. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506.
44. Zhang G, Zhang J, Wang B, et al. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A retrospective analysis. Respir. Res. 2020;21
45. Du R-H, Liu L-M, Yin W, et al. Hospitalization and Critical Care of 109 Decedents with COVID-19 Pneumonia in Wuhan, China. Ann. Am. Thorac. Soc. 2020;
46. Zhang Y, Zheng L, Liu L, et al. Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city, China. Liver Int. 2020;
47. Wan S, Xiang Y, Fang W, et al. Clinical features and treatment of COVID-19 patients in northeast Chongqing. J. Med. Virol. 2020;
48. Wang Z, Yang B, Li Q, et al. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin. Infect. Dis. 2020;
49. Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect. Dis. 2020;20:425–434.
50. Cai Q, Huang D, Ou P, et al. COVID-19 in a Designated Infectious Diseases Hospital Outside Hubei Province, China. Allergy 2020;
51. Zheng F, Tang W, Li H, et al. Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur. Rev. Med. Pharmacol. Sci. 2020;24:3404–3410.
52. Li L, Li S, Xu M, et al. Risk factors related to hepatic injury in patients with corona virus disease 2019. medRxiv 2020;
53. Li X, Xu S, Yu M, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J. Allergy Clin. Immunol. 2020;
54. Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;
55. Zhang X, Cai H, Hu J, et al. Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings. Int. J. Infect. Dis. 2020;
56. Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;
57. Liu Y, Du X, Chen J, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J. Infect. 2020;
58. Meng H, Xiong R, He R, et al. CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China. J. Infect. 2020;
59. Zheng Y, Xu H, Yang M, et al. Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. J. Clin. Virol. 2020;127:104366.
60. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008-2012.
Artículos relacionados

Carta

Gastric bronchogenic cyst

DOI: 10.17235/reed.2023.9964/2023

Carta

Gastric schwannoma diagnosing gastric stromal tumor

DOI: 10.17235/reed.2023.9919/2023

Carta

Blue rubber bleb nevus syndrome

DOI: 10.17235/reed.2023.9913/2023

Imagen en Patología Digestiva

Extremely giant liver hemangioma: a case beyond the norms

DOI: 10.17235/reed.2023.9877/2023

Imagen en Patología Digestiva

Enteroenteric intussusception caused by a small bowel metastatic cutaneous melanoma

DOI: 10.17235/reed.2023.9876/2023

Editorial

Diagnóstico y manejo del síndrome de Abernethy

DOI: 10.17235/reed.2023.9781/2023

Carta

Upper gastrointestinal bleeding and Rigler triad

DOI: 10.17235/reed.2023.9731/2023

Carta

Gastric duplication cyst with peristalsis

DOI: 10.17235/reed.2023.9721/2023

Carta

Amyloidosis: a rare cause of severe acute liver failure

DOI: 10.17235/reed.2023.9598/2023

Carta

Linfoma MALT de colon: un desafío endoscópico

DOI: 10.17235/reed.2023.9595/2023

Carta

Sindrome ictérico secundario a poliquistosis hepática

DOI: 10.17235/reed.2023.9590/2023

Carta

Autoimmune hepatitis after SARS-C¬¬oV-2 vaccination

DOI: 10.17235/reed.2023.9579/2023

Carta

The role of gastrointestinal endoscopy in Kaposi sarcoma

DOI: 10.17235/reed.2023.9534/2023

Carta

Alteraciones hepáticas en la enfermedad celiaca

DOI: 10.17235/reed.2023.9516/2023

Carta

Recurrencia del schwannoma gástrico

DOI: 10.17235/reed.2023.9480/2023

Carta

Intestinal pneumatosis as a manifestation of systemic sclerosis

DOI: 10.17235/reed.2023.9428/2022

Editorial

A new year and a new roadmap for the journal in challenging times

DOI: 10.17235/reed.2022.9372/2022

Imagen en Patología Digestiva

Germ cell tumor with duodenal involvement: a rare case of gastrointestinal bleeding

DOI: 10.17235/reed.2022.9327/2022

Carta

Vaginal lesion as first manifestation of colorectal disease

DOI: 10.17235/reed.2022.9270/2022

Carta

Budd-Chiari syndrome in Behçet’s disease

DOI: 10.17235/reed.2022.9267/2022

Carta

An unexpected gastric cardia submucosal lesion

DOI: 10.17235/reed.2022.9260/2022

Imagen en Patología Digestiva

Esófago negro

DOI: 10.17235/reed.2022.9217/2022

Imagen en Patología Digestiva

Colangiopatía post-COVID: hallazgos ultrasonográficos y de CPRE

DOI: 10.17235/reed.2022.9218/2022

Imagen en Patología Digestiva

Intrabiliary metastasis of colorectal adenocarcinoma: the SPY perspective

DOI: 10.17235/reed.2022.9202/2022

Carta

Primary gastric leiomyosarcoma presenting as a giant polyp

DOI: 10.17235/reed.2022.9165/2022

Carta

A rare cause of obscure gastrointestinal bleeding

DOI: 10.17235/reed.2022.9156/2022

Imagen en Patología Digestiva

A rare endoscopic pattern in a patient with gastroesophageal reflux disease

DOI: 10.17235/reed.2022.9124/2022

Imagen en Patología Digestiva

The sentinel polyp: high-grade sarcoma revealed after colonic polypectomy

DOI: 10.17235/reed.2022.9093/2022

Carta

A full hemostatic repertoire in a complex cirrhotic patient

DOI: 10.17235/reed.2022.9039/2022

Carta

Hemostasis of a bleeding inverted colonic diverticulum

DOI: 10.17235/reed.2022.9019/2022

Carta

Sepsis secundaria a gastritis flemonosa en paciente oncológica

DOI: 10.17235/reed.2022.9009/2022

Editorial

Drug induced liver injury by immunotherapy

DOI: 10.17235/reed.2022.9179/2022

Carta

No es GIST todo lo que parece

DOI: 10.17235/reed.2022.8974/2022

Carta

¿Melanoma intestinal primario?

DOI: 10.17235/reed.2022.8944/2022

Carta

Amiloidosis intestinal: un reto diagnóstico

DOI: 10.17235/reed.2022.8934/2022

Carta

Angiomiolipoma epitelioide hepático como hallazgo incidental

DOI: 10.17235/reed.2022.8895/2022

Carta

Angiosarcoma epitelioide intraabdominal

DOI: 10.17235/reed.2022.8878/2022

Revisión

Inmunoterapia en el carcinoma hepatocelular

DOI: 10.17235/reed.2022.8876/2022

Carta

Retracted articles in Gastroenterology

DOI: 10.17235/reed.2022.8859/2022

Imagen en Patología Digestiva

Hallazgo inusual en cirugía esofagogástrica: antracosis gástrica

DOI: 10.17235/reed.2022.8882/2022

Imagen en Patología Digestiva

Acute respiratory failure secondary to megaesophagus: think beyond COVID-19

DOI: 10.17235/reed.2022.8847/2022

Imagen en Patología Digestiva

Infección gastrointestinal por Mycobacterium avium con presentación endoscópica inhabitual

DOI: 10.17235/reed.2022.8845/2022

Carta

A rare cause of a bulging mass in the mid esophagus

DOI: 10.17235/reed.2022.8834/2022

Editorial

Chronic intestinal failure: an overview and future perspectives

DOI: 10.17235/reed.2022.8827/2022

Imagen en Patología Digestiva

An unusual cause of a protuberant lesion of the gastric antrum

DOI: 10.17235/reed.2022.8771/2022

Carta

Analysis of retracted articles in the field of Gastroenterology

DOI: 10.17235/reed.2022.8760/2022

Imagen en Patología Digestiva

Absceso hepático por Parvimonas micra

DOI: 10.17235/reed.2022.8751/2022

Carta

Abdomen agudo quirúrgico y vacunación de COVID-19

DOI: 10.17235/reed.2022.8721/2022

Imagen en Patología Digestiva

Colonic Kaposi’s sarcoma as the first clinical manifestation of undiagnosed HIV

DOI: 10.17235/reed.2022.8717/2022

Imagen en Patología Digestiva

When needles are not enough, forceps delivers!

DOI: 10.17235/reed.2022.8697/2022

Carta

Gran úlcera gástrica perforada por consumo de cocaína

DOI: 10.17235/reed.2022.8676/2022

Imagen en Patología Digestiva

Síndrome de encefalopatía posterior reversible (PRES) en el postrasplante hepático

DOI: 10.17235/reed.2022.8694/2022

Imagen en Patología Digestiva

Tumor neuroendocrino ileal como causa infrecuente de hemorragia digestiva de origen oscuro

DOI: 10.17235/reed.2022.8641/2022

Editorial

Acute pancreatitis: an opportunity for gastroenterology hospitalists?

DOI: 10.17235/reed.2022.8573/2022

Carta

Hepatitis AMA positivo inducida por la vacuna contra SARS-CoV-2

DOI: 10.17235/reed.2022.8533/2021

Carta

Gastric ulcer with liver penetration

DOI: 10.17235/reed.2022.8528/2021

Carta

Neurotoxicidad por ertapenem

DOI: 10.17235/reed.2021.8469/2021

Imagen en Patología Digestiva

Anemia induced by hemangioma at the duodenal papilla, resected by endoscopic mucosal resection

DOI: 10.17235/reed.2022.8439/2021

Imagen en Patología Digestiva

Abuso de cocaína crack como causa no descrita de obstrucción del vaciamiento gástrico

DOI: 10.17235/reed.2022.8438/2021

Imagen en Patología Digestiva

Colangiopatía isquémica secundaria a trombosis y seudoaneurisma de artería hepática

DOI: 10.17235/reed.2021.8395/2021

Carta

A case of COVID-19 with concomitant infection with hepatitis A

DOI: 10.17235/reed.2021.8372/2021

Carta

Endoscopic full-thickness resection of a gastric schwannoma

DOI: 10.17235/reed.2021.8385/2021

Imagen en Patología Digestiva

Hepatocarcinoma quístico gigante en ausencia de cirrosis

DOI: 10.17235/reed.2021.8313/2021

Imagen en Patología Digestiva

Bezoar: an uncommon cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2021.8311/2021

Imagen en Patología Digestiva

Kaposi’s sarcoma with atypical gastrointestinal involvement

DOI: 10.17235/reed.2021.8275/2021

Carta

COVID-19 and aorto-enteric fistula

DOI: 10.17235/reed.2021.8272/2021

Imagen en Patología Digestiva

A case of duodenal-type follicular lymphoma

DOI: 10.17235/reed.2021.8233/2021

Carta

Unexpected diagnosis for nodular hepatic lesions

DOI: 10.17235/reed.2021.8230/2021

Imagen en Patología Digestiva

Pedunculated mucosa-associated lymphoid tissue (MALT) lymphoma causing gastric outlet obstruction

DOI: 10.17235/reed.2021.8204/2021

Imagen en Patología Digestiva

Imaging findings of melanoma metastasis in the gallbladder

DOI: 10.17235/reed.2021.8176/2021

Carta

Migración de clip tras colecistectomía

DOI: 10.17235/reed.2021.8156/2021

Imagen en Patología Digestiva

Ink stained gastric lesions: a rare cause of gastrointestinal bleeding

DOI: 10.17235/reed.2021.8141/2021

Imagen en Patología Digestiva

Isquemia gástrica: hallazgos transversales por imagen a través de una serie de casos

DOI: 10.17235/reed.2021.8142/2021

Imagen en Patología Digestiva

Trombosis portal en un paciente con infección por SARS-CoV-2

DOI: 10.17235/reed.2021.8099/2021

Carta

EBVMCU in a liver-transplant patient

DOI: 10.17235/reed.2021.8064/2021

Imagen en Patología Digestiva

Abdominal cocoon sign: an unusual cause of intestinal obstruction

DOI: 10.17235/reed.2021.8057/2021

Carta

Hepatitis autoinmune desencadenada por la COVID-19

DOI: 10.17235/reed.2021.8045/2021

Imagen en Patología Digestiva

A rare case of emphysematous gastritis caused by Lactobacillus fermentum in a patient with diabetes

DOI: 10.17235/reed.2021.7951/2021

Revisión

Revisión del diagnóstico y manejo del quiste hidatídico hepático

DOI: 10.17235/reed.2021.7896/2021

Carta

Neumoperitoneo y COVID-19. ¿Una asociación causal?

DOI: 10.17235/reed.2021.7877/2021

Imagen en Patología Digestiva

Síndrome de Dubin-Johnson como hallazgo en una laparoscopia

DOI: 10.17235/reed.2021.7866/2021

Carta

COVID-19 and the liver: the chicken or the egg dilemma

DOI: 10.17235/reed.2021.7861/2021

Imagen en Patología Digestiva

Gastric plasmacytoma: a rare cause of upper gastrointestinal bleeding

DOI: 10.17235/reed.2021.7816/2021

Carta

Daño pancreático: pancreatitis aguda en pacientes COVID-19

DOI: 10.17235/reed.2021.7807/2021

Carta

Bochdalek hernia: use of capsule endoscopy

DOI: 10.17235/reed.2021.7760/2020

Carta

Cirugía radical en hidatidosis hepática

DOI: 10.17235/reed.2021.7743/2020

Editorial

Gobernar en tiempos turbulentos con afán de servir

DOI: 10.17235/reed.2020.7684/2020

Imagen en Patología Digestiva

Sarcoma de células dendríticas foliculares pseudotumor inflamatorio-like del hígado

DOI: 10.17235/reed.2020.7602/2020

Carta

Pancreatic injury in COVID-19: pathogenesis and challenges

DOI: 10.17235/reed.2020.7541/2020

Carta

Gastric caustic injury after organophosphate poisoning

DOI: 10.17235/reed.2020.7540/2020

Carta

SARS-CoV-2 and acute pancreatitis: a new etiological agent?

DOI: 10.17235/reed.2020.7481/2020

Revisión

La fragilidad física en el contexto del trasplante hepático

DOI: 10.17235/reed.2020.7448/2020

Carta

COVID-19. Immunothrombosis and the gastrointestinal tract

DOI: 10.17235/reed.2020.7292/2020

Carta

Daño hepatocelular inducido por doxazosina

DOI: 10.17235/reed.2020.7268/2020

Carta

Hepatitis aguda por olmesartán: una entidad infrecuente

DOI: 10.17235/reed.2020.7236/2020

Carta

Acute gastric dilatation in a patient with anorexia nervosa

DOI: 10.17235/reed.2020.7235/2020

Carta

Manejo de los aneurismas de la arteria hepática

DOI: 10.17235/reed.2020.7219/2020

Carta

Efecto del Adacolumn® en colitis ulcerosa con COVID-19

DOI: 10.17235/reed.2020.7156/2020

Revisiones Rápidas

COVID-19, coronavirus, SARS-CoV-2 and the small bowel

DOI: 10.17235/reed.2020.7137/2020

Imagen en Patología Digestiva

Hemangioendotelioma epitelioide como causa infrecuente de tumor hepático

DOI: 10.17235/reed.2020.7127/2020

Carta

Chronic intestinal pseudo-obstruction in MELAS

DOI: 10.17235/reed.2020.7099/2020

Original

Fibromixoma plexiforme gástrico, un tumor mesenquimal infrecuente

DOI: 10.17235/reed.2020.7048/2020

Revisión

Pyroptosis in liver disease

DOI: 10.17235/reed.2020.7034/2020

Carta

Biopsia en el carcinoma hepatocelular: solo en ocasiones

DOI: 10.17235/reed.2020.6935/2020

Carta

Luetic gastritis: an uncommon cause of gastritis

DOI: 10.17235/reed.2020.6870/2020

Imagen en Patología Digestiva

Pancreatitis del surco: una rara causa de dilatación gástrica severa

DOI: 10.17235/reed.2020.6765/2019

Editorial

Pequeños pero grandes pasos

DOI: 10.17235/reed.2019.6758/2019

Carta

Úlcera gástrica por mucormicosis en paciente crítico

DOI: 10.17235/reed.2020.6636/2019

Carta

Quiste broncogénico atípico con sobreinfección fúngica

DOI: 10.17235/reed.2020.6560/2019

Original

A new pattern in hepatitis A virus infection in an urban population

DOI: 10.17235/reed.2020.6526/2019

Carta

Misplacement of a nasogastric feeding tube: a case report

DOI: 10.17235/reed.2020.6512/2019

Carta

Coriocarcinoma gástrico primario

DOI: 10.17235/reed.2020.6478/2019

Imagen en Patología Digestiva

Metástasis de melanoma en la vesícula biliar: un hallazgo infrecuente

DOI: 10.17235/reed.2020.6407/2019

Carta

Gastritis isquémica secundaria al hierro oral

DOI: 10.17235/reed.2019.6401/2019

Caso Clínico

Hepatocarcinoma sobre hígado ectópico peritoneal

DOI: 10.17235/reed.2019.6408/2019

Imagen en Patología Digestiva

Concurrent hepatic and renal angiomyolipomas in tuberous sclerosis complex

DOI: 10.17235/reed.2020.6376/2019

Imagen en Patología Digestiva

Presentación endoscópica inusual de una heterotopia gástrica en bulbo duodenal

DOI: 10.17235/reed.2020.6372/2019

Caso Clínico

Esofagitis enfisematosa con perforación gástrica

DOI: 10.17235/reed.2019.6322/2019

Revisión

Psoriasis e hígado graso: una sinergia perjudicial

DOI: 10.17235/reed.2019.6263/2019

Carta

Mastocitosis sistémica diagnosticada endoscópicamente

DOI: 10.17235/reed.2019.6246/2019

Imagen en Patología Digestiva

Artrodesis cervical penetrada en esófago detectada mediante gastroscopia

DOI: 10.17235/reed.2019.6222/2019

Artículo Especial

La calidad en ecografía digestiva: un aspecto que urge consensuar

DOI: 10.17235/reed.2019.6177/2019

Carta

Adenoma serrado gástrico

DOI: 10.17235/reed.2019.6145/2018

Carta

Absceso hepático gigante por Fasciola hepatica

DOI: 10.17235/reed.2019.6136/2018

Imagen en Patología Digestiva

A rare heterotopic gastric mucosa appearing between the muscularis mucosae and submucosa

DOI: 10.17235/reed.2019.6134/2018

Artículo Especial

Indicadores de calidad en gastroscopia. Procedimiento de la gastroscopia

DOI: 10.17235/reed.2019.6023/2018

Imagen en Patología Digestiva

Plasmocitoma gastroduodenal secundario en paciente con mieloma múltiple

DOI: 10.17235/reed.2019.5923/2018

Carta

A veces las cosas son lo que parecen

DOI: 10.17235/reed.2019.5911/2018

Carta

Primary squamous cell carcinoma of the stomach: a rare entity

DOI: 10.17235/reed.2018.5900/2018

Imagen en Patología Digestiva

Poliposis linfomatosa pseudotumoral en íleon terminal secundaria a linfoma MALT gastrointestinal

DOI: 10.17235/reed.2019.5772/2018

Editorial

Trasplante de pulmón y disfunción esofágica

DOI: 10.17235/reed.2018.5693/2018

Imagen en Patología Digestiva

Signo de la cuerda de Kantor en paciente con brote de enfermedad de Crohn

DOI: 10.17235/reed.2018.5598/2018

Imagen en Patología Digestiva

Ictericia indolora como debut de adenocarcinoma pulmonar

DOI: 10.17235/reed.2018.5587/2018

Carta

An esophageal cyst containing heterotopic gastric glands

DOI: 10.17235/reed.2018.5530/2018

Imagen en Patología Digestiva

Dysphagia and hematemesis caused by an intramural esophageal dissection

DOI: 10.17235/reed.2018.5471/2018

Carta

Giant hepatobiliary cystadenoma: clinic-pathological findings

DOI: 10.17235/reed.2018.5414/2017

Carta al Editor

Post-transplant lymphoproliferative disease after liver transplantation

DOI: 10.17235/reed.2017.5387/2017

Carta al Editor

EUS-guided ethanol ablation therapy for gastric stromal tumors

DOI: 10.17235/reed.2017.5361/2017

Carta al Editor

Quistes peribiliares complicados en paciente sin enfermedad hepática previa

DOI: 10.17235/reed.2017.5350/2017

Carta al Editor

Hemorragia digestiva grave de origen oscuro resuelta con idarucizumab

DOI: 10.17235/reed.2018.5298/2017

Carta al Editor

A patient with Castleman’s disease mimicking acute pancreatitis

DOI: 10.17235/reed.2017.5120/2017

Carta al Editor

Dilatación gástrica aguda tras transgresión dietética

DOI: 10.17235/reed.2017.5111/2017

Imagen en Patología Digestiva

Shunt intrahepático portocava en paciente con quiste hidatídico que comprime vena cava inferior

DOI: 10.17235/reed.2017.4983/2017

Imagen en Patología Digestiva

Metástasis de dermatofibrosarcoma diagnosticada mediante cápsula endoscópica

DOI: 10.17235/reed.2018.4900/2017

Carta al Editor

Tumores neuroendocrinos pancreáticos

DOI: 10.17235/reed.2017.4725/2016

Original

Utilidad del balón intragástrico previo a cirugía bariátrica

DOI: 10.17235/reed.2017.4624/2016

Imagen en Patología Digestiva

Debut de cirrosis hepática poco habitual

Carta al Editor

Hematoma gástrico intramural en el contexto de una pancreatitis aguda

DOI: 10.17235/reed.2017.4494/2016

Imagen en Patología Digestiva

Jejunal metastasis of renal cell carcinoma

Original

Síndrome linfoproliferativo en el trasplante hepático

DOI: 10.17235/reed.2017.4228/2016

Carta al Editor

Manejo del neumoperitoneo no quirúrgico

DOI: 10.17235/reed.2016.4215/2016

Caso Clínico

The clinical extremes of autoimmune cholangitis

DOI: 10.17235/reed.2017.4167/2015

Revisión

Lesiones serradas y síndrome de poliposis serrada

DOI: 10.17235/reed.2017.4065/2015

Carta al Editor

Lupus como manifestación paraneoplásica de colangiocarcinoma

DOI: 10.17235/reed.2016.4064/2015

Carta al Editor

Metástasis traqueobronquiales de cáncer colorrectal

DOI: 10.17235/reed.2016.4080/2015

Carta al Editor

Acute transverse colon volvulus with secondary gastric isquemia. Case report

DOI: 10.17235/reed.2016.4024/2015

Carta al Editor

Hiatal herniation following total gastrectomy

DOI: 10.17235/reed.2016.4009/2015

Carta al Editor

Gastric neuroendocrine tumor presenting with gastrointestinal bleeding

DOI: 10.17235/reed.2015.3998/2015

Carta al Editor

Endoscopic submucosal dissection for a gastric fibrolipoma

DOI: 10.17235/reed.2015.3982/2015

Caso Clínico

Enfermedad de Crohn metastásica en pediatría

DOI: 10.17235/reed.2016.3948/2015

Carta al Editor

Respuesta de los autores: Español o inglés en la comunicación científica

DOI: 10.17235/reed.2015.3945/2015

Caso Clínico

Glycogenic hepatopathy in young adults: a case series

DOI: 10.17235/reed.2016.3934/2015

Imagen en Patología Digestiva

Spontaneous intramural hematoma of the colon

Caso Clínico

Melanoma esofágico primario: descripción de un caso

DOI: 10.17235/reed.2016.3908/2015

Caso Clínico

Varicela gástrica: dos casos en pacientes oncológicos

DOI: 10.17235/reed.2016.3925/2015

Caso Clínico

Sangrado apendicular: una causa excepcional de hemorragia digestiva baja

DOI: 10.17235/reed.2015.3828/2015

Imagen en Patología Digestiva

Tumor de células granulares en ciego

Revisión

Neoplasia intraepitelial anal: una revisión de conjunto

DOI: 10.17235/reed.2015.3788/2015

Caso Clínico

Pelvic inflammatory myofibroblastic tumor mimicking a rectal cancer

DOI: 10.17235/reed.2015.3777/2015

Carta al Editor

Acute gastric dilatation in the context of bulimia nervosa

DOI: 10.17235/reed.2015.3673/2015

Carta al Editor

Duodenal involvement by seminomatous tumors

DOI: 10.17235/reed.2015.3646/2014

Carta al Editor

Leiomyosarcoma of the ascending colon: a rare tumor with poor prognosis

DOI: 10.17235/reed.2015.3606/2014

Carta al Editor

PITAVASTATINA: OTRA ESTATINA A EMPLEAR Y VIGILAR

DOI: 10.17235/reed.2015.3565/2014

Carta al Editor

Absceso hepático por Eikenella Corrodens

DOI: 10.17235/reed.2015.3613/2014

Carta al Editor

Leiomioma del ligamento redondo hepático: descripción de un caso

DOI: 10.17235/reed.2015.3725/2014

Instrucciones para citar
Ampuero J, Sánchez Y, García-Lozano M, Maya-Miles D, Romero Gómez M. Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis. 7397/2020


Descargar en un gestor de citas

Descargue la cita de este artículo haciendo clic en uno de los siguientes gestores de citas:

Métrica
Este artículo ha sido visitado 1410 veces.
Este artículo ha sido descargado 363 veces.

Estadísticas de Dimensions


Estadísticas de Plum Analytics

Ficha Técnica

Recibido: 08/07/2020

Aceptado: 24/09/2020

Prepublicado: 03/12/2020

Publicado: 08/02/2021

Tiempo de revisión del artículo: 72 días

Tiempo de prepublicación: 148 días

Tiempo de edición del artículo: 215 días


Compartir
Este artículo ha sido valorado por 1 lectores .
Valoración del lector:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
La REED es el órgano oficial de la Sociedad Española de Patología Digestiva, la SociedadEspañola de Endoscopia Digestiva y la Asociación Española de Ecografía Digestiva
Política de cookies Política de Privacidad Aviso Legal © Copyright 2023 y Creative Commons. Revista Española de Enfermedades Digestivas