Year 2024 / Volume 116 / Number 2
Original
Ulcerative colitis overall disease severity index predicts colectomy: a prospective cohort study

77-82

DOI: 10.17235/reed.2023.9754/2023

Shengduo He, Hong Jiang, Yu Tian, Wei Zhang, Guigen Teng, Huahong Wang,

Abstract
Background: ulcerative colitis (UC) overall disease severity index (DSI) has been established. A prospective cohort study was performed to find the value of DSI to predict colectomy within one and four years and explored the association between DSI and other indexes. Methods: the hospitalized UC patients were enrolled from March 2018 to January 2019 in this single center study. DSI, Truelove and Witts criteria, Mayo index and Seo index were assessed by medical records. Outcome was whether to undergo colectomy within one and four years and was obtained by telephone survey or medical records. Index values of predicting colectomy within one and four years were evaluated using receiver operating characteristics (ROC) curves. Results: one hundred and thirty-eight of 233 hospitalized UC patients were enrolled. Within one year, the follow-up period was less than one year for six patients and two patients had died. A further nine patients underwent colectomy. The Spearman correlation coefficient between DSI and Truelove and Witts criteria, Mayo index and Seo index were 0.730, 0.839 and 0.843, respectively. Using these indices to predict colectomy within one and four years, the area under the curve of DSI was more than those of other indices and the cut-off value of DSI was 79. Conclusions: a good correlation of DSI with other indexes was demonstrated. DSI can be used to predict the need for colectomy within one or four years.
Lay Summary
Ulcerative colitis (UC) overall disease severity index (DSI) has been established. This study identified the value of DSI to predict colectomy within one and four years and explored the association between DSI and other indexes. The hospitalized UC patients were enrolled from March 2018 to January 2019 in this single center study. DSI and other indexes were assessed by medical records. Outcome was whether to undergo colectomy within one and four years and was obtained by telephone survey or medical records. The index value of predicting colectomy within one and four years was evaluated using receiver operating characteristics (ROC) curves. We enrolled 138 of 233 hospitalized UC patients. Nine patients underwent colectomy within one year. The Spearman correlation coefficient between DSI and Truelove&Witts criteria, Mayo index and Seo index was 0.730, 0.839, and 0.843, respectively. Using these indexes to predict colectomy within one and four years, the area under the curve of DSI was more than those of other indexes. We demonstrated DSI had a good correlation with other indexes. DSI can be used to predict the need for colectomy within one or four years.
Share Button
New comment
Comments
No comments for this article
References
1. Cosnes, J., C. Gowerrousseau, P. Seksik et al., Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology,vol. 140,no. 6, pp. 1785-1794,2011.
2. Molodecky, N.A., I.S. Soon, D.M. Rabi et al., Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology,vol. 142,no. 1, pp. 46-54,2012.
3. Jiang, X.L. H.F. Cui, An analysis of 10218 ulcerative colitis cases in China. World Journal of Gastroenterology,vol. 8,no. 1, pp. 158-161,2002.
4. Zeng, Z., Z. Zhu, Y. Yang et al., Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China: a prospective population-based study. Journal of Gastroenterology and Hepatology,vol. 28,no. 7, pp. 1148-1153,2013.
5. Walsh, A.J., R.V. Bryant S.P.L. Travis, Current best practice for disease activity assessment in IBD. Nature Reviews Gastroenterology & Hepatology,vol. 13,no. 567,2016.
6. Schroeder, K.W., W.J. Tremaine D.M. Ilstrup, Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. New England Journal of Medicine,vol. 317,no. 26, pp. 1625-1629,1987.
7. Truelove, S.C. L.J. Witts, Cortisone in ulcerative colitis; final report on a therapeutic trial. British Medical Journal,vol. 2,no. 4947, pp. 1041-1048,1955.
8. Harbord, M., R. Eliakim, D. Bettenworth et al., Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management. Journal of Crohn's & Colitis,vol. 11,no. 7, pp. 769-784,2017.
9. Ferrante, M., S. Declerck, G. De Hertogh et al., Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. Inflammatory Bowel Diseases,vol. 14,no. 1, pp. 20-28,2008.
10. Leijonmarck, C.E., P.G. Persson G. Hellers, Factors affecting colectomy rate in ulcerative colitis: an epidemiologic study. Gut,vol. 31,no. 3, pp. 329-333,1990.
11. Ho, G.T., C. Mowat, C.J. Goddard et al., Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second-line medical therapy or surgery. Alimentary Pharmacology and Therapeutics,vol. 19,no. 10, pp. 1079-1087,2004.
12. Hoie, O., F.L. Wolters, L. Riis et al., Low colectomy rates in ulcerative colitis in an unselected European cohort followed for 10 years. Gastroenterology,vol. 132,no. 2, pp. 507-515,2007.
13. Solberg, I.C., I. Lygren, J. Jahnsen et al., Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study). Scandinavian Journal of Gastroenterology,vol. 44,no. 4, pp. 431-440,2009.
14. Ananthakrishnan, A.N., E.L. McGinley, D.G. Binion et al., Simple score to identify colectomy risk in ulcerative colitis hospitalizations. Inflammatory Bowel Diseases,vol. 16,no. 9, pp. 1532-1540,2010.
15. Dias, C.C., P.P. Rodrigues, A. da Costa-Pereira et al., Clinical predictors of colectomy in patients with ulcerative colitis: systematic review and meta-analysis of cohort studies. Journal of Crohn's & Colitis,vol. 9,no. 2, pp. 156-163,2015.
16. Ananthakrishnan, A.N., M. Issa, D.B. Beaulieu et al., History of medical hospitalization predicts future need for colectomy in patients with ulcerative colitis. Inflammatory Bowel Diseases,vol. 15,no. 2, pp. 176-181,2009.
17. Seo, M., M. Okada, T. Yao et al., Evaluation of the clinical course of acute attacks in patients with ulcerative colitis through the use of an activity index. Journal of Gastroenterology,vol. 37,no. 1, pp. 29-34,2002.
18. Peyrin-Biroulet, L., J. Panés, W.J. Sandborn et al., Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions. Clinical Gastroenterology and Hepatology,vol. 14,no. 3, pp. 348-354,2016.
19. Koliani-Pace, J.L. C.A. Siegel, Beyond disease activity to overall disease severity in inflammatory bowel disease. The Lancet Gastroenterology and Hepatology,vol. 2,no. 9, pp. 624-626,2017.
20. Siegel, C.A., C.B. Whitman, B.M.R. Spiegel et al., Development of an index to define overall disease severity in IBD. Gut,vol. 67,no. 2, pp. 244-254,2018.
21. Magro, F., P. Gionchetti, R. Eliakim et al., Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders. Journal of Crohn's & Colitis,vol. 11,no. 6, pp. 649-670,2017.
22. Seo, M., M. Okada, T. Yao et al., An index of disease activity in patients with ulcerative colitis. American Journal of Gastroenterology,vol. 87,no. 8, pp. 971-976,1992.
23. Frolkis, A.D., J. Dykeman, M.E. Negrón et al., Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies. Gastroenterology,vol. 145,no. 5, pp. 996-1006,2013.
24. Macaluso, F.S., F. Cavallaro, C. Felice et al., Risk factors and timing for colectomy in chronically active refractory ulcerative colitis: A systematic review. Digestive and Liver Disease,vol.,2019.
25. D’Haens, G., W.J. Sandborn, B.G. Feagan et al., A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis. Gastroenterology,vol. 132,no. 2, pp. 763-786,2007.
26. Burisch, J., K.H. Katsanos, D.K. Christodoulou et al., Natural Disease Course of Ulcerative Colitis during the First Five Years of Follow-up in a European Population-based Inception Cohort - An Epi-IBD Study. Journal of Crohn's and Colitis,vol. 13,no. 2, pp. 198-208,2019.
1. Cosnes, J., C. Gowerrousseau, P. Seksik et al., Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology,vol. 140,no. 6, pp. 1785-1794,2011.
Related articles

Letter

Tofacitinib-induced eosinophilia

DOI: 10.17235/reed.2023.9831/2023

Letter

Perianal Paget’s disease

DOI: 10.17235/reed.2022.9304/2022

Letter

Chinese dragon sign of ulcerative colitis

DOI: 10.17235/reed.2022.9154/2022

Letter

Ulcerative colitis exacerbated by strongyloidiasis

DOI: 10.17235/reed.2022.9044/2022

Letter

Mesalazine induced interstitial pneumonitis in the COVID era

DOI: 10.17235/reed.2022.8635/2021

Letter

The effect of Adacolumn® on ulcerative colitis with COVID-19

DOI: 10.17235/reed.2020.7156/2020

Letter

Sweet syndrome in severe ulcerative flare

DOI: 10.17235/reed.2020.6995/2020

Letter to the Editor

Ulcerative colitis with gastric and duodenal involvement

DOI: 10.17235/reed.2017.4685/2016

Editorial

Specialist care in the management of inflammatory bowel disease

DOI: 10.17235/reed.2016.4628/2016

Original

Mercaptopurine and inflammatory bowel disease: the other thiopurine

DOI: 10.17235/reed.2016.4546/2016

Case Report

Mesalamine-induced myopericarditis - A case report

DOI: 10.17235/reed.2016.4016/2015

Citation tools
He S, Jiang H, Tian Y, Zhang W, Teng G, Wang H, et all. Ulcerative colitis overall disease severity index predicts colectomy: a prospective cohort study . 9754/2023


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 432 visits.
This article has been downloaded 73 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 30/05/2023

Accepted: 20/08/2023

Online First: 14/09/2023

Published: 07/02/2024

Article revision time: 70 days

Article Online First time: 107 days

Article editing time: 253 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology