REED - Revista Española de Enfermedades Digestivas

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English version

Año 2019 / Volumen 111 / Número 8
Original

Supervivencia y morbimortalidad del adenocarcinoma de páncreas tratado con duodenopancreatectomía cefálica con extirpación total del mesopáncreas

609-614

DOI: 10.17235/reed.2019.6139/2018

Pablo Sánchez Acedo, Javier Herrera Cabezón, Cruz Zazpe Ripa, Antonio Tarifa Castilla,

Resumen

Introducción: el adenocarcinoma de páncreas es la neoplasia maligna más frecuente del área periampular; con una supervivencia a cinco años, se sitúa en torno al 20%. Objetivo: el objetivo de nuestro estudio es mostrar los resultados de supervivencia y seguridad de los pacientes intervenidos mediante duodenopancreatectomía cefálica con extirpación total del mesopáncreas (ETMP). Material y métodos: estudio observacional prospectivo que incluye 114 pacientes con adenocarcinoma de páncreas, intervenidos mediante duodenopancreatectomía con ETMP entre 2008 y 2017. Se analizaron las variables demográficas, el estadio tumoral, el número de ganglios extirpados, la ratio ganglionar, la clasificación R y los factores pronósticos del intervalo libre de enfermedad y la supervivencia mediante un análisis multivariante. Resultados: presentaron complicaciones 54 (47,3%) pacientes; 22 (19,3%) se clasificaron como graves. La mortalidad fue del 4,3%. El seguimiento medio fue de 26,2 meses. Durante este periodo, 73 (64%) pacientes presentaron una recaída con un intervalo medio de 40,9 meses. El patrón de recaída fue principalmente hepático (26,3%), seguido de la recaída local (20%). La supervivencia media fue del 40,38% y la actuarial, del 26,6% a cinco años. Los factores relacionados con la recaída fueron la estadificación T3 o superior (RR 8,1 [1,1; 61]) y las resecciones R1 (RR 13,4 [2,7; 66,5]) y con la supervivencia, las resecciones R1 (RR 10,7 [2,5; 46,2]). Conclusión: la ETMP garantiza una linfadenectomía y una ratio ganglionar adecuadas según los estándares publicados. La supervivencia de los pacientes intervenidos por adenocarcinoma de páncreas en nuestro centro es del 68,4% a un año y del 26,6% a cinco años. El principal factor de recaída y de mortalidad son las resecciones R1.

Nuevo comentario

Comentarios

21/10/2019 6:36:57
Soy cirujano oncológo y me parece interesante ver las tasas de sobrevida en pacientes con cáncer de pancreas cuando se emplea la ETMP

Bibliografía

1. Hidalgo M, Cascinu S, Kleeff J, et al. Addressing the challenges of pancreatic cancer: Future directions for improving outcomes. Pancreatol Off J Int Assoc Pancreatol . [et al]. 2015;15(1):8-18. doi:10.1016/j.pan.2014.10.001.

DOI: 10.1016/j.pan.2014.10.001

2. Sabater L, Calvete J, Aparisi L, et al. [Pancreatic and periampullary tumors: morbidity, mortality, functional results and long-term survival]. Cirugía Española. 2009;86(3):159-166. doi:10.1016/j.ciresp.2009.03.014.

DOI: 10.1016/j.ciresp.2009.03.014

3. Saif MW. Advancements in the management of pancreatic cancer: 2013. JOP J pancreas. 2013;14(2):112-118. http://www.ncbi.nlm.nih.gov/pubmed/23474549.

4. Gockel I, Domeyer M, Wolloscheck T, Konerding MA, Junginger T. Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space. World J Surg Oncol. 2007;5:44. doi:10.1186/1477-7819-5-44.

DOI: 10.1186/1477-7819-5-44

5. Pessaux P, Regenet N, Arnaud JP. [Resection of the retroportal pancreatic lamina during a cephalic pancreaticoduodenectomy: first dissection of the superior mesenteric artery]. Ann Chir. 2003;128(9):633-636.

DOI: 10.1016/j.anchir.2003.10.010

6. Pessaux P, Varma D, Arnaud J-P. Pancreaticoduodenectomy: superior mesenteric artery first approach. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006;10(4):607-611. doi:10.1016/j.gassur.2005.05.001.

DOI: 10.1016/j.gassur.2005.05.001

7. Figueras J, Codina-Barreras A, López-Ben S, et al. [Cephalic duodenopancreatectomy in periampullary tumours. Dissection of the superior mesenteric artery as aninitial approach. Description of the technique and an assessment of our initial experience]. Cirugía española. 2008;83(4):186-193. http://www.ncbi.nlm.nih.gov/pubmed/18358178.

8. Sanjay P, Takaori K, Govil S, Shrikhande S V., Windsor JA. “Artery-first” approaches to pancreatoduodenectomy. Br J Surg. 2012;99(8):1027-1035. doi:10.1002/bjs.8763.

DOI: 10.1002/bjs.8763

9. Adham M, Singhirunnusorn J. Surgical technique and results of total mesopancreas excision (TMpE) in pancreatic tumors. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2012;38(4):340-345. doi:10.1016/j.ejso.2011.12.015.

DOI: 10.1016/j.ejso.2011.12.015

10. Ramia JM, De-la-Plaza R, Manuel-Vazquez A, Lopez-Marcano A, Morales R. Systematic review of the mesopancreas: concept and clinical implications. Clin Transl Oncol. 2018;20(11):1385-1391. doi:10.1007/s12094-018-1869-5.

DOI: 10.1007/s12094-018-1869-5

11. Bockhorn M, Uzunoglu FG, Adham M, et al. Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2014;155(6):977-988. doi:10.1016/j.surg.2014.02.001.

DOI: 10.1016/j.surg.2014.02.001

12. Tol JAMG, Gouma DJ, Bassi C, et al. Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery. 2014;156(3):591-600. doi:10.1016/j.surg.2014.06.016.

DOI: 10.1016/j.surg.2014.06.016

13. Gockel I, Domeyer M, Wolloscheck T, Konerding MA, Junginger T. Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space. World J Surg Oncol. 2007;5:44. doi:10.1186/1477-7819-5-44.

DOI: 10.1186/1477-7819-5-44

14. Shrikhande S V., Sivasanker M, Vollmer CM, et al. Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. December 2016. doi:10.1016/j.surg.2016.11.021.

DOI: 10.1016/j.surg.2016.11.021

15. Delcore R, Thomas JH, Pierce GE, Hermreck AS. Pancreatogastrostomy: a safe drainage procedure after pancreatoduodenectomy. Surgery. 1990;108(4):641-645; discussion 645-647. http://www.ncbi.nlm.nih.gov/pubmed/2218874.

16. Herrera-Cabezón FJ, Sánchez-Acedo P, Zazpe-Ripa C, Tarifa-Castilla A, Lera-Tricas JM. Quality standards in 480 pancreatic resections: a prospective observational study. Rev Esp Enferm Dig. 2015;107(3):143-151. http://www.ncbi.nlm.nih.gov/pubmed/25733038. Accessed December 15, 2017.

17. Haljamäe H. Anesthetic risk factors. Acta Chir Scand Suppl. 1989;550:11-9; discussion 19-21. http://www.ncbi.nlm.nih.gov/pubmed/2652961. Accessed July 13, 2018.

18. Dindo D, Demartines N, Clavien P-A. Classification of Surgical Complications. Ann Surg. 2004;240(2):205-213. doi:10.1097/01.sla.0000133083.54934.ae.

DOI: 10.1097/01.sla.0000133083.54934.ae

19. Bassi C, Dervenis C, Butturini G, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138(1):8-13. doi:10.1016/j.surg.2005.05.001.

DOI: 10.1016/j.surg.2005.05.001

20. Wente MN, Bassi C, Dervenis C, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142(5):761-768. doi:10.1016/j.surg.2007.05.005.

DOI: 10.1016/j.surg.2007.05.005

21. Welsch T, Eisele H, Zschäbitz S, Hinz U, Büchler MW, Wente MN. Critical appraisal of the International Study Group of Pancreatic Surgery (ISGPS) consensus definition of postoperative hemorrhage after pancreatoduodenectomy. Langenbecks Arch Surg. 2011;396(6):783-791. doi:10.1007/s00423-011-0811-x.

DOI: 10.1007/s00423-011-0811-x

22. Lüttges J. [What’s new? The 2010 WHO classification for tumours of the pancreas]. Pathologe. 2011;32 Suppl 2:332-336. doi:10.1007/s00292-011-1515-2.

DOI: 10.1007/s00292-011-1515-2

23. Pawlik TM, Gleisner AL, Cameron JL, et al. Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer. Surgery. 2007;141(5):610-618. doi:10.1016/j.surg.2006.12.013.

DOI: 10.1016/j.surg.2006.12.013

24. Shukla PJ, Barreto SG, Fingerhut A, et al. Toward improving uniformity and standardization in the reporting of pancreatic anastomoses: a new classification system by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2010;147(1):144-153. doi:10.1016/j.surg.2009.09.003.

DOI: 10.1016/j.surg.2009.09.003

25. Sabater L, Mora I, Gámez del Castillo JM, et al. Estándares de calidad en la cirugía oncológica pancreática en España. Cirugía Española. 2018;96(6):342-351. doi:10.1016/j.ciresp.2018.03.002.

DOI: 10.1016/j.ciresp.2018.03.002

26. Katz MHG, Wang H, Fleming JB, et al. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol. 2009;16(4):836-847. doi:10.1245/s10434-008-0295-2.

DOI: 10.1245/s10434-008-0295-2

27. Huebner M, Kendrick M, Reid-Lombardo KM, et al. Number of lymph nodes evaluated: prognostic value in pancreatic adenocarcinoma. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2012;16(5):920-926. doi:10.1007/s11605-012-1853-2.

DOI: 10.1007/s11605-012-1853-2

28. Tomlinson JS, Jain S, Bentrem DJ, et al. Accuracy of Staging Node-Negative Pancreas Cancer. Arch Surg. 2007;142(8):767. doi:10.1001/archsurg.142.8.767.

DOI: 10.1001/archsurg.142.8.767

29. Riediger H, Keck T, Wellner U, et al. The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2009;13(7):1337-1344. doi:10.1007/s11605-009-0919-2.

DOI: 10.1007/s11605-009-0919-2

30. Showalter TN, Winter KA, Berger AC, et al. The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704. Int J Radiat Oncol Biol Phys. 2011;81(5):1328-1335. doi:10.1016/j.ijrobp.2010.07.1993.

DOI: 10.1016/j.ijrobp.2010.07.1993

31. Dusch N, Weiss C, Ströbel P, Kienle P, Post S, Niedergethmann M. Factors predicting long-term survival following pancreatic resection for ductal adenocarcinoma of the pancreas: 40 years of experience. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2014;18(4):674-681. doi:10.1007/s11605-013-2408-x.

DOI: 10.1007/s11605-013-2408-x

32. Sun J, Yang Y, Wang X, et al. Meta-analysis of the efficacies of extended and standard pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas. World J Surg. 2014;38(10):2708-2715. doi:10.1007/s00268-014-2633-9.

DOI: 10.1007/s00268-014-2633-9

33. Ke K, Chen W, Chen Y. Standard and extended lymphadenectomy for adenocarcinoma of the pancreatic head: a meta-analysis and systematic review. J Gastroenterol Hepatol. 2014;29(3):453-462. doi:10.1111/jgh.12393.

DOI: 10.1111/jgh.12393

34. Hishinuma S, Ogata Y, Tomikawa M, Ozawa I, Hirabayashi K, Igarashi S. Patterns of recurrence after curative resection of pancreatic cancer, based on autopsy findings. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006;10(4):511-518. doi:10.1016/j.gassur.2005.09.016.

DOI: 10.1016/j.gassur.2005.09.016

35. Sugiura T, Uesaka K, Mihara K, et al. Margin status, recurrence pattern, and prognosis after resection of pancreatic cancer. Surgery. 2013;154(5):1078-1086. doi:10.1016/j.surg.2013.04.015.

DOI: 10.1016/j.surg.2013.04.015

36. Kawabata Y, Tanaka T, Nishi T, Monma H, Yano S, Tajima Y. Appraisal of a total meso-pancreatoduodenum excision with pancreaticoduodenectomy for pancreatic head carcinoma. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2012;38(7):574-579. doi:10.1016/j.ejso.2012.04.007.

DOI: 10.1016/j.ejso.2012.04.007

37. Kawabata Y, Nishi T, Tanaka T, Tajima Y. Safety and Feasibility of a Pancreaticoduodenectomy with Total Meso-Pancreatoduodenum Excision: Analysis in Various Periampullary Disorders. Hepatogastroenterology. 2014;61(131):821-827. http://www.ncbi.nlm.nih.gov/pubmed/26176080. Accessed November 20, 2018.

38. Wu W, Wang X, Wu X, et al. Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases. Chin J Cancer Res. 2016;28(4):423-428. doi:10.21147/j.issn.1000-9604.2016.04.05.

DOI: 10.21147/j.issn.1000-9604.2016.04.05

39. Mirkin KA, Hollenbeak CS, Wong J. Greater lymph node retrieval and lymph node ratio impacts survival in resected pancreatic cancer. J Surg Res. 2017;220:12-24. doi:10.1016/j.jss.2017.06.076.

DOI: 10.1016/j.jss.2017.06.076

40. Tempero MA, Malafa MP, Behrman SW, et al. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2014;12(8):1083-1093. http://www.ncbi.nlm.nih.gov/pubmed/25099441. Accessed November 20, 2018.

41. Slidell MB, Chang DC, Cameron JL, et al. Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol. 2008;15(1):165-174. doi:10.1245/s10434-007-9587-1.

DOI: 10.1245/s10434-007-9587-1

42. Vuarnesson H, Lupinacci RM, Semoun O, et al. Number of examined lymph nodes and nodal status assessment in pancreaticoduodenectomy for pancreatic adenocarcinoma. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2013;39(10):1116-1121. doi:10.1016/j.ejso.2013.07.089.

DOI: 10.1016/j.ejso.2013.07.089

43. Tol J a. MG, Brosens L a. A, van Dieren S, et al. Impact of lymph node ratio on survival in patients with pancreatic and periampullary cancer. Br J Surg. 2015;102(3):237-245. doi:10.1002/bjs.9709.

DOI: 10.1002/bjs.9709

Adham, M., and J. Singhirunnusorn. 2012. “Surgical Technique and Results of Total Mesopancreas Excision (TMpE) in Pancreatic Tumors.” European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 38 (4): 340–45. https://doi.org/10.1016/j.ejso.2011.12.015.

Bassi, Claudio, Christos Dervenis, Giovanni Butturini, Abe Fingerhut, Charles Yeo, Jakob Izbicki, John Neoptolemos, et al. 2005. “Postoperative Pancreatic Fistula: An International Study Group (ISGPF) Definition.” Surgery 138 (1): 8–13. https://doi.org/10.1016/j.surg.2005.05.001.

Bockhorn, Maximilian, Faik G. Uzunoglu, Mustapha Adham, Clem Imrie, Miroslav Milicevic, Aken A. Sandberg, Horacio J. Asbun, et al. 2014. “Borderline Resectable Pancreatic Cancer: A Consensus Statement by the International Study Group of Pancreatic Surgery (ISGPS).” Surgery 155 (6): 977–88. https://doi.org/10.1016/j.surg.2014.02.001.

Delcore, R., J. H. Thomas, G. E. Pierce, and A. S. Hermreck. 1990. “Pancreatogastrostomy: A Safe Drainage Procedure after Pancreatoduodenectomy.” Surgery 108 (4): 641-645; discussion 645-647. http://www.ncbi.nlm.nih.gov/pubmed/2218874.

Dindo, Daniel, Nicolas Demartines, and Pierre-Alain Clavien. 2004. “Classification of Surgical Complications.” Annals of Surgery 240 (2): 205–13. https://doi.org/10.1097/01.sla.0000133083.54934.ae.

Dusch, Niloufar, Christel Weiss, Philip Ströbel, Peter Kienle, Stefan Post, and Marco Niedergethmann. 2014. “Factors Predicting Long-Term Survival Following Pancreatic Resection for Ductal Adenocarcinoma of the Pancreas: 40 Years of Experience.” Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract 18 (4): 674–81. https://doi.org/10.1007/s11605-013-2408-x.

Figueras, Joan, Antonio Codina-Barreras, Santiago López-Ben, Albert Maroto, Silvia Torres-Bahí, Héctor Daniel González, Maite Albiol, et al. 2008. “[Cephalic duodenopancreatectomy in periampullary tumours. Dissection of the superior mesenteric artery as aninitial approach. Description of the technique and an assessment of our initial experience].” Cirugía española 83 (4): 186–93. http://www.ncbi.nlm.nih.gov/pubmed/18358178.

Gockel, Ines, Mario Domeyer, Tanja Wolloscheck, Moritz A. Konerding, and Theodor Junginger. 2007a. “Resection of the Mesopancreas (RMP): A New Surgical Classification of a Known Anatomical Space.” World Journal of Surgical Oncology 5: 44. https://doi.org/10.1186/1477-7819-5-44.

Gockel, Ines, Mario Domeyer, Tanja Wolloscheck, Moritz A Konerding, and Theodor Junginger. 2007b. “Resection of the Mesopancreas (RMP): A New Surgical Classification of a Known Anatomical Space.” World Journal of Surgical Oncology 5: 44. https://doi.org/10.1186/1477-7819-5-44.

Haljamäe, H. 1989. “Anesthetic Risk Factors.” Acta Chirurgica Scandinavica. Supplementum 550: 11-9; discussion 19-21. http://www.ncbi.nlm.nih.gov/pubmed/2652961.

Herrera-Cabezón, Francisco Javier, Pablo Sánchez-Acedo, Cruz Zazpe-Ripa, Antonio Tarifa-Castilla, and José Miguel Lera-Tricas. 2015. “Quality Standards in 480 Pancreatic Resections: A Prospective Observational Study.” Revista Espanola de Enfermedades Digestivas : Organo Oficial de La Sociedad Espanola de Patologia Digestiva 107 (3): 143–51. http://www.ncbi.nlm.nih.gov/pubmed/25733038.

Hidalgo, Manuel, Stefano Cascinu, Jörg Kleeff, Roberto Labianca, J.-Matthias Löhr, John Neoptolemos, Francisco X. Real, Jean-Luc Van Laethem, and Volker Heinemann. 2015. “Addressing the Challenges of Pancreatic Cancer: Future Directions for Improving Outcomes.” Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.] 15 (1): 8–18. https://doi.org/10.1016/j.pan.2014.10.001.

Hishinuma, Shoichi, Yoshiro Ogata, Moriaki Tomikawa, Iwao Ozawa, Kaoru Hirabayashi, and Seiji Igarashi. 2006. “Patterns of Recurrence after Curative Resection of Pancreatic Cancer, Based on Autopsy Findings.” Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract 10 (4): 511–18. https://doi.org/10.1016/j.gassur.2005.09.016.

Huebner, Marianne, Michael Kendrick, Kaye M Reid-Lombardo, Florencia Que, Terry Therneau, Rui Qin, John Donohue, David Nagorney, Michael Farnell, and Michael Sarr. 2012. “Number of Lymph Nodes Evaluated: Prognostic Value in Pancreatic Adenocarcinoma.” Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract 16 (5): 920–26. https://doi.org/10.1007/s11605-012-1853-2.

Katz, Matthew H G, Huamin Wang, Jason B Fleming, Charlotte C Sun, Rosa F Hwang, Robert A Wolff, Gauri Varadhachary, et al. 2009. “Long-Term Survival after Multidisciplinary Management of Resected Pancreatic Adenocarcinoma.” Annals of Surgical Oncology 16 (4): 836–47. https://doi.org/10.1245/s10434-008-0295-2.

Kawabata, Y., T. Tanaka, T. Nishi, H. Monma, S. Yano, and Y. Tajima. 2012. “Appraisal of a Total Meso-Pancreatoduodenum Excision with Pancreaticoduodenectomy for Pancreatic Head Carcinoma.” European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 38 (7): 574–79. https://doi.org/10.1016/j.ejso.2012.04.007.

Kawabata, Y, T Nishi, T Tanaka, and Y Tajima. 2014. “Safety and Feasibility of a Pancreaticoduodenectomy with Total Meso-Pancreatoduodenum Excision: Analysis in Various Periampullary Disorders.” Hepato-Gastroenterology 61 (131): 821–27. http://www.ncbi.nlm.nih.gov/pubmed/26176080.

Ke, Kun, Wen Chen, and Yanling Chen. 2014. “Standard and Extended Lymphadenectomy for Adenocarcinoma of the Pancreatic Head: A Meta-Analysis and Systematic Review.” Journal of Gastroenterology and Hepatology 29 (3): 453–62. https://doi.org/10.1111/jgh.12393.

Lüttges, J. 2011. “[What’s new? The 2010 WHO classification for tumours of the pancreas].” Der Pathologe 32 Suppl 2 (November): 332–36. https://doi.org/10.1007/s00292-011-1515-2.

Mirkin, Katelin A, Christopher S Hollenbeak, and Joyce Wong. 2017. “Greater Lymph Node Retrieval and Lymph Node Ratio Impacts Survival in Resected Pancreatic Cancer.” The Journal of Surgical Research 220 (December): 12–24. https://doi.org/10.1016/j.jss.2017.06.076.

Pawlik, Timothy M., Ana L. Gleisner, John L. Cameron, Jordan M. Winter, Lia Assumpcao, Keith D. Lillemoe, Christopher Wolfgang, et al. 2007. “Prognostic Relevance of Lymph Node Ratio Following Pancreaticoduodenectomy for Pancreatic Cancer.” Surgery 141 (5): 610–18. https://doi.org/10.1016/j.surg.2006.12.013.

Pessaux, P, N Regenet, and J P Arnaud. 2003. “[Resection of the retroportal pancreatic lamina during a cephalic pancreaticoduodenectomy: first dissection of the superior mesenteric artery].” Annales de chirurgie 128 (9): 633–36.

DOI: 10.1016/j.anchir.2003.10.010

Pessaux, Patrick, Deepak Varma, and Jean-Pierre Arnaud. 2006. “Pancreaticoduodenectomy: Superior Mesenteric Artery First Approach.” Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract 10 (4): 607–11. https://doi.org/10.1016/j.gassur.2005.05.001.

Ramia, J M, R De-la-Plaza, A Manuel-Vazquez, A Lopez-Marcano, and R Morales. 2018. “Systematic Review of the Mesopancreas: Concept and Clinical Implications.” Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20 (11): 1385–91. https://doi.org/10.1007/s12094-018-1869-5.

Riediger, Hartwig, Tobias Keck, Ulrich Wellner, Axel zur Hausen, Ulrich Adam, Ulrich T Hopt, and Frank Makowiec. 2009. “The Lymph Node Ratio Is the Strongest Prognostic Factor after Resection of Pancreatic Cancer.” Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract 13 (7): 1337–44. https://doi.org/10.1007/s11605-009-0919-2.

Sabater, Luis, Julio Calvete, Luis Aparisi, Raul Cánovas, Elena Muñoz, Ramón Añón, Susana Roselló, et al. 2009. “[Pancreatic and periampullary tumors: morbidity, mortality, functional results and long-term survival].” Cirugía Española 86 (3): 159–66. https://doi.org/10.1016/j.ciresp.2009.03.014.

Sabater, Luis, Isabel Mora, Juan Manuel Gámez del Castillo, Javier Escrig-Sos, Elena Muñoz-Forner, Marina Garcés-Albir, Dimitri Dorcaratto, and Joaquín Ortega. 2018. “Estándares de Calidad En La Cirugía Oncológica Pancreática En España.” Cirugía Española 96 (6): 342–51. https://doi.org/10.1016/j.ciresp.2018.03.002.

Saif, Muhammad Wasif. 2013. “Advancements in the Management of Pancreatic Cancer: 2013.” JOP: Journal of the Pancreas 14 (2): 112–18. http://www.ncbi.nlm.nih.gov/pubmed/23474549.

Sanjay, P., K. Takaori, S. Govil, S. V. Shrikhande, and J. A. Windsor. 2012. “‘Artery-First’ Approaches to Pancreatoduodenectomy.” The British Journal of Surgery 99 (8): 1027–35. https://doi.org/10.1002/bjs.8763.

Showalter, Timothy N, Kathryn A Winter, Adam C Berger, William F Regine, Ross A Abrams, Howard Safran, John P Hoffman, Al B Benson, John S MacDonald, and Christopher G Willett. 2011. “The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Node Ratio on Survival after Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer: A Secondary Analysis of RTOG 9704.” International Journal of Radiation Oncology, Biology, Physics 81 (5): 1328–35. https://doi.org/10.1016/j.ijrobp.2010.07.1993.

Shrikhande, Shailesh V., Masillamany Sivasanker, Charles M. Vollmer, Helmut Friess, Marc G. Besselink, Abe Fingerhut, Charles J. Yeo, et al. 2016. “Pancreatic Anastomosis after Pancreatoduodenectomy: A Position Statement by the International Study Group of Pancreatic Surgery (ISGPS).” Surgery, December. https://doi.org/10.1016/j.surg.2016.11.021.

Slidell, Mark B., David C. Chang, John L. Cameron, Christopher Wolfgang, Joseph M. Herman, Richard D. Schulick, Michael A. Choti, and Timothy M. Pawlik. 2008. “Impact of Total Lymph Node Count and Lymph Node Ratio on Staging and Survival after Pancreatectomy for Pancreatic Adenocarcinoma: A Large, Population-Based Analysis.” Annals of Surgical Oncology 15 (1): 165–74. https://doi.org/10.1245/s10434-007-9587-1.

Sugiura, Teiichi, Katsuhiko Uesaka, Kisho Mihara, Keiko Sasaki, Hideyuki Kanemoto, Takashi Mizuno, and Yukiyasu Okamura. 2013. “Margin Status, Recurrence Pattern, and Prognosis after Resection of Pancreatic Cancer.” Surgery 154 (5): 1078–86. https://doi.org/10.1016/j.surg.2013.04.015.

Sun, Jingfeng, Yinxue Yang, Xuan Wang, Zhen Yu, Ting Zhang, Jun Song, Hewei Zhao, et al. 2014. “Meta-Analysis of the Efficacies of Extended and Standard Pancreatoduodenectomy for Ductal Adenocarcinoma of the Head of the Pancreas.” World Journal of Surgery 38 (10): 2708–15. https://doi.org/10.1007/s00268-014-2633-9.

Tempero, Margaret A, Mokenge P Malafa, Stephen W Behrman, Al B Benson, Ephraim S Casper, E Gabriela Chiorean, Vincent Chung, et al. 2014. “Pancreatic Adenocarcinoma, Version 2.2014: Featured Updates to the NCCN Guidelines.” Journal of the National Comprehensive Cancer Network : JNCCN 12 (8): 1083–93. http://www.ncbi.nlm.nih.gov/pubmed/25099441.

Tol, J. a. M. G., L. a. A. Brosens, S. van Dieren, T. M. van Gulik, O. R. C. Busch, M. G. H. Besselink, and D. J. Gouma. 2015. “Impact of Lymph Node Ratio on Survival in Patients with Pancreatic and Periampullary Cancer.” The British Journal of Surgery 102 (3): 237–45. https://doi.org/10.1002/bjs.9709.

Tol, Johanna A. M. G., Dirk J. Gouma, Claudio Bassi, Christos Dervenis, Marco Montorsi, Mustapha Adham, Ake Andrén-Sandberg, et al. 2014. “Definition of a Standard Lymphadenectomy in Surgery for Pancreatic Ductal Adenocarcinoma: A Consensus Statement by the International Study Group on Pancreatic Surgery (ISGPS).” Surgery 156 (3): 591–600. https://doi.org/10.1016/j.surg.2014.06.016.

Tomlinson, James S., Sushma Jain, David J Bentrem, Evangelos G Sekeris, Melinda A Maggard, O Joe Hines, Howard A Reber, and Clifford Y Ko. 2007. “Accuracy of Staging Node-Negative Pancreas Cancer.” Archives of Surgery 142 (8): 767. https://doi.org/10.1001/archsurg.142.8.767.

Verbeke, C. S., D. Leitch, K. V. Menon, M. J. McMahon, P. J. Guillou, and A. Anthoney. 2006. “Redefining the R1 Resection in Pancreatic Cancer.” British Journal of Surgery 93 (10): 1232–37. https://doi.org/10.1002/bjs.5397.

Vuarnesson, H, R M Lupinacci, O Semoun, M Svrcek, C Julié, P Balladur, C Penna, J B Bachet, M Resche-Rigon, and F Paye. 2013. “Number of Examined Lymph Nodes and Nodal Status Assessment in Pancreaticoduodenectomy for Pancreatic Adenocarcinoma.” European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 39 (10): 1116–21. https://doi.org/10.1016/j.ejso.2013.07.089.

Welsch, Thilo, Hanna Eisele, Stefanie Zschäbitz, Ulf Hinz, Markus W Büchler, and Moritz N Wente. 2011. “Critical Appraisal of the International Study Group of Pancreatic Surgery (ISGPS) Consensus Definition of Postoperative Hemorrhage after Pancreatoduodenectomy.” Langenbeck’s Archives of Surgery / Deutsche Gesellschaft Für Chirurgie 396 (6): 783–91. https://doi.org/10.1007/s00423-011-0811-x.

Wente, Moritz N, Claudio Bassi, Christos Dervenis, Abe Fingerhut, Dirk J Gouma, Jakob R Izbicki, John P Neoptolemos, et al. 2007. “Delayed Gastric Emptying (DGE) after Pancreatic Surgery: A Suggested Definition by the International Study Group of Pancreatic Surgery (ISGPS).” Surgery 142 (5): 761–68. https://doi.org/10.1016/j.surg.2007.05.005.

Wu, Wenguang, Xu’an Wang, Xiangsong Wu, Maolan Li, Hao Weng, Yang Cao, Ruifa Bao, et al. 2016. “Total Mesopancreas Excision for Pancreatic Head Cancer: Analysis of 120 Cases.” Chinese Journal of Cancer Research = Chung-Kuo Yen C

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Recibido: 22/12/2018

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Publicado: 31/07/2019

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