Year 2025 / Volume 117 / Number 12
Letter
Refractory gastroduodenal ulcers: investigating non-peptic etiologies

782-783

DOI: 10.17235/reed.2024.10782/2024

Pablo Fernández Rodríguez, Mario Calvo Soto, Luis Miguel García, Jorge Mendoza Jiménez-Ridruejo, Cecilio Santander Vaquero, Raquel Herranz Pérez,

Abstract
This article presents two clinical cases of gastroduodenal peptic ulcers refractory to medical treatment. In both cases, malignancy was excluded following persistent lesions observed in repeated endoscopies, leading to the use of surgery as both a diagnostic and therapeutic approach. These refractory cases require a multidisciplinary approach with a broad differential diagnosis, including etiologies such as toxic substance exposure, persistent Helicobacter pylori infection, or poor adherence to medical treatment, along with less common conditions such as malignancy, acid hypersecretion syndromes, vascular disorders, or immune-mediated diseases.
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References
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2. Kim HU. Diagnostic and Treatment Approaches for Refractory Peptic Ulcers. Clin Endosc. 2015 Jul;48(4):285-90.
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4. Napolitano L. Refractory peptic ulcer disease. Gastroenterol Clin North Am. 2009 Jun;38(2):267-88.
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Citation tools
Fernández Rodríguez P, Calvo Soto M, Miguel García L, Mendoza Jiménez-Ridruejo J, Santander Vaquero C, Herranz Pérez R, et all. Refractory gastroduodenal ulcers: investigating non-peptic etiologies. 10782/2024


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Publication history

Received: 09/09/2024

Accepted: 16/09/2024

Online First: 04/10/2024

Published: 12/12/2025

Article Online First time: 25 days

Article editing time: 459 days


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