Year 2021 / Volume 113 / Number 1
Letter
Villous atrophy persistence in celiac disease despite following a gluten-free diet must be clarified

76

DOI: 10.17235/reed.2020.7033/2020

Sandra Izquierdo Santervás, Luis Fernández Salazar,

Abstract
We read with great interest the article recently published in REED by Shadegi et al. Villous atrophy (VA) persists in 35 % and 23.7 % of celiac disease (CD) patients for six and 24 months, respectively, after following a gluten-free diet (GFD). The authors think that the time following a GFD must be longer than two years in some patients to achieve mucosal healing and we agree with this. Our experience comes from a short series of ten females and three males with CD, diagnosed at an average age of 36 years (15-72) based on serology (anti-TG2 > 10 IU/ml or anti-Em positive) and a duodenal biopsy showing VA. All cases followed a GFD, according to the anamnesis and underwent a second duodenal biopsy and anti-TG2 determination after 42 (10-202) months. Immunogenic peptides of gluten (IPG) in feces were determined in four patients.
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24/07/2024 14:19:01
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References
1. Sadeghi A, Rad N, Ashtari S, et al. The value of a biopsy in celiac disease follow up: assessment of the small bowel after 6 and 24 months treatment with a gluten free diet. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 2020;112(2):101-8.
2. Comino I, Fernandez-Banares F, Esteve M, et al. Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients. The American journal of gastroenterology. 2016;111(10):1456-65.
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Izquierdo Santervás S, Fernández Salazar L. Villous atrophy persistence in celiac disease despite following a gluten-free diet must be clarified. 7033/2020


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Publication history

Received: 06/03/2020

Accepted: 12/03/2020

Online First: 17/11/2020

Published: 11/01/2021

Article Online First time: 256 days

Article editing time: 311 days


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