Year 2016 / Volume 108 / Number 11
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Sprue-like enteropathy associated with olmesartan in a patient with villous atrophy, HLA-DQ2 genotype and antinuclear antibodies

732-733

Isidro Machado, María Reolid, Fernando Martínez de Juan, Carmen Martínez Lapiedra, Fernanda Maia de Alcántara,

Abstract
We describe a new case of enteropathy with villous atrophy in a patient suffering from arterial hypertension treated with olmesartan. The molecular and serological studies showed anti-nuclear antibodies (ANA) and haplotype HLA-DQ2 positive, as well as negative results for anti-transglutaminase, anti-endomysium and anti-enterocytes antibodies. A duodenal villous atrophy was suspected by upper gastrointestinal endoscopy, which was confirmed by histopathology. The morphological picture was suggestive of sprue-like enteropathy with severe lymphoid infiltration and predominant T lymphoid cells.
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References
1- Greywoode R, Braunstein ED, Arquelles-Grande C et al. Olmesartan, other antihypertensives, and chronic diarrhea among patients undergoing endoscopic procedures: a case control study. Mayo Clin Proc 2014; 89: 1239–43. doi: 10.1016/j.mayocp.2014.05.012.
2- Marthey L, Cadiot G, Seksik P et al. Olmesartan-associated enteropathy: results of a national survey. Aliment Pharmacol Ther. 2014;40:1103–9. doi: 10.1111/apt.12937.
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4- Téllez Villajos L, Crespo Pérez L, Cano Ruiz A et al. Enteropatia por olmesartan. Med Clin (Barc). 2015;144:140-1. doi: 10.1016/j.medcli.2014.06.006.
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Citation tools
Machado I, Reolid M, Martínez de Juan F, Martínez Lapiedra C, Maia de Alcántara F. Sprue-like enteropathy associated with olmesartan in a patient with villous atrophy, HLA-DQ2 genotype and antinuclear antibodies . 3991/2015


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Publication history

Received: 01/09/2015

Accepted: 05/10/2015

Published: 02/11/2016

Article revision time: 33 days

Article editing time: 428 days


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