Year 2022 / Volume 114 / Number 11
Original
Oro-dental lesions in pediatric patients with celiac disease: an observational retrospective clinical study

654-659

DOI: 10.17235/reed.2022.8422/2021

Francesco Saverio Ludovichetti, Anna Giulia Signoriello, Luca Girotto, Luca Del Dot, Silvia Piovan, Sergio Mazzoleni,

Abstract
Background and aim of the study: To investigate the correlation between celiac disease and specific oral lesions. Methods: 114 pediatric patients were enrolled and divided into three groups: celiac patients (CD group), patients with malabsorption without celiac disease (non-CD group) and healthy controls. Oral lesions of hard and soft tissues were detected and analyzed by Fisher’s test and Odds Ratio calculations. Major Results: A non-random correlation between the three groups and the rate of enamel defects was detected. The CD group showed more severe enamel defects compared to the non-CD group. A non-random association between the three groups and the number of mucous lesions was not observed. Furthermore, malabsorption patterns not related to the celiac disease involved a relatively modest risk of specific enamel defects compared to controls. Conclusions: Hypoplastic enamel defects of the permanent teeth could be reliable indicators for celiac disease. The etiology of specific hypoplastic enamel lesions mainly has to be sought in the autoimmune response triggered by gluten, while the malabsorption would play only a minor role. Lesions of the oral mucous membranes should not be considered as specific risk indicators, however they represent a non-specific marker of malabsorption.
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References
1. Cervino, G., Fiorillo, L., Laino, L., Herford, A.S., Lauritano, F., Giudice, G.L., Famà, F., Santoro, R., Troiano, G., Iannello, G., Cicciù, M. (2018). Oral Health Impact Profile in Celiac Patients: Analysis of Recent Findings in a Literature Review. Gastroenterology Research and Practice, 7848735. doi: 10.1155/2018/7848735.
2. Spinell, T., DeMayo, F., Cato, M., Thai, A., Helmerhorst, E. V., Green, P. H. R., … Demmer R. T. (2018). The association between coeliac disease and periodontitis: results from NHANES 2009– 2012. Journal of Clinical Periodontology, 45(3): 303 - 310. doi: 10.1111/jcpe.12856
3. Hill, I., Dirks, M., Liptak, G. S., Colletti, R. B., Fasano, A., Guandalini, S., … Seidman E. G. (2005). Guideline for the diagnosis and treatment of celiac disease in children: recomendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 40(1), 1 - 19. doi: 10.1097/00005176-200501000-00001
4. Rivera, E., Assiri, A., Guandalini, S. (2013). Celiac disease. Oral Diseases, 19(7): 635 – 641. doi:10.1111/odi.12091
5. Aine, L., Maki, M., Collin, P., Keyrilainen, O. (1990). Dental enamel defects in coeliac disease. Journal of Oral Pathology & Medicine, 19, 241 – 245. doi: 10.1111/j.1600-0714.1990.tb00834.x.
6. Ballinger, A., Huges, C., Kumar, P., Hutchinson, I., Clark, M. (1994). Dental enamel defects in coeliac disease. Lancet, 343, 230 - 231. doi: 10.1016/s0140-6736(94)91013-8
7. Bramanti, E., Cicciù, M., Matacena, G., Costa, S., Magazzù, G. (2014). Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study. Gastroenterology Research and Practice, 934159. doi: 10.1155/2014/934159
8. Wierink, C. D., Van Diermen, D. E., Aartman, A. H. A., Heymans, H. A. S. (2007). Dental enamel defects in children with coeliac disease. International Journal of Paediatric Dentistry, 17(3), 163 - 168. doi: 10.1111/j.1365-263X.2006.00816.x
9. Pastore, L., Carroccio, A., Compilato, D., Panzarella, V., Serpico, R., Lo Muzio, L. (2008). Oral manifestations of celiac disease. Journal of Clinical Gastroenterology, 42(3), 224 - 232. doi: 10.1097/MCG.0b013e318074dd98
10. Acar, S., Yetkiner, A. A., Ersin, N., Oncag, O., Aydogdu, S., Arikan, C. (2012). Oral findings and salivary parameters in children with celiac disease: a preliminary study. Medical Principles and Practice 21: 129 - 133. doi: 10.1159/000331794.
11. Rivera, E., Assiri, A., Guandalini, S. (2013). Celiac disease. Oral Diseases, 19(7): 635 – 641. doi:10.1111/odi.12091
12. Martelossi, S., Zanatta, E., Santo, E., Clarich, P., Radovich, P., & Ventura, A. (1996). Dental enamel defects and screening for coeliac disease. Acta Paediatrica, 85(s412), 47–48. doi:10.1111/j.1651-2227.1996.tb14249.x
13. Campisi, G., Di Liberto, C., Iacono, G. Compilato, D., Di Prima, L., Calvino, F., …, Carroccio, A. (2007). Oral pathology in untreated coeliac disease. Alimentary Pharmacology & Therapeutics, 26(11-12), 1529–1536. doi:10.1111/j.1365-2036.2007.03535.x
14. Rashid, M., Cranney, A., Zarkadas, M., Graham, I. D., Switzer, C., Case, S., …Decker Butzner, J. (2005). Celiac disease: evaluation of the diagnosis and dietary compliance in Canadian children. Pediatrics, 116(6), e754 – e759. doi: 10.1542/peds.2005-0904
15. Aine L. Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc. 1986;82 Suppl 3:1-71. PMID: 3725749.
16. Nieri, M., Tofani, E., Defraia, E., Giuntini, V., Franchi, L. (2017). Enamel defects and aphthous stomatitis in celiac and healthy subjects: Systematic review and meta-analysis of controlled studies. Journal of Dentistry, 65, 1 - 10. doi: 10.1016/j.jdent.2017.07.001
17. Shteyer, E., Berson, T., Lachmanovitz, O., Hidas, A., Wilschanski, M., Menachem, M., … Moskovitz, M. (2013). Oral Health Status and Salivary Properties in Relation to Gluten-free Diet in Children With Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition, 57(1), 49 - 52. doi:10.1097/mpg.0b013e31828b3705
18. Bıçak, D. A., Urgancı, N., Akyüz, S., Usta, M., Kızılkan, N. U., Alev, B., Yarat, A. (2018). Clinical evaluation of dental enamel defects and oral findings in coeliac children. European Oral Research, 52(3), 150 - 156. doi: 10.26650/eor.2018.525.
19. Bucci, P., Carile, F., Sangianantoni, A., D’Angiò, F., Santarelli, A., Lo Muzio, L. (2006). Oral aphthous ulcers and dental enamel defects in children with coeliac disease. Acta Paediatrica, 95(2), 203 - 207. doi: 10.1080/08035250500355022
20. Farmakis E, Puntis JW, Toumba KJ. Enamel defects in children with coeliac disease. Eur J Paediatr Dent. 2005 Sep;6(3):129-32. PMID: 16216092.
21. Ventura, A., Martellossi, S. (1997). Dental enamel defects and coeliac disease. Archives of Disease in Childhood, 77(1), 91. doi: 10.1136/adc.77.1.91
22. Kuloglu, Z., Doganci, T., Kansu, A., Demirceken, F., Duman, M., Tutkak, H., …Girgin, N. (2008). HLA types in Turkish children with celiac disease. The Turkish Journal of Pediatrics, 50(6), 515 – 520
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Ludovichetti F, Signoriello A, Girotto L, Del Dot L, Piovan S, Mazzoleni S, et all. Oro-dental lesions in pediatric patients with celiac disease: an observational retrospective clinical study. 8422/2021


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Publication history

Received: 28/10/2021

Accepted: 14/02/2022

Online First: 16/02/2022

Published: 07/11/2022

Article revision time: 104 days

Article Online First time: 111 days

Article editing time: 375 days


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