Year 2022 / Volume 114 / Number 11
Editorial
Orthohepevirus C as causal agent of acute hepatitis in Spain

639-640

DOI: 10.17235/reed.2022.8993/2022

Antonio Rivero-Juárez, Mario Frías, Antonio Rivero,

Abstract
Recently, it has been reported the first cases of acute hepatitis linked to Orthohepevirus C, supposing the first cases in Europe. In this editorial, we summarized the main findings of this study, evidence of the viral circulation among human and animal populations, as well as the research points that need to be assessed regarding the epidemiology, clinical management and diagnosis of this emerging virus.
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References
[1] Smith DB, Izopet J, Nicot F, Simmonds P, Jameel S, Meng XJ, Norder H, Okamoto H, van der Poel WHM, Reuter G, Purdy MA. Update: proposed reference sequences for subtypes of hepatitis E virus (species Orthohepevirus A). J Gen Virol. 2020 Jul;101(7):692-698. doi: 10.1099/jgv.0.001435. PMID: 32469300; PMCID: PMC7660235.
[2] World Health Organization. Global hepatitis report, 2017. Available at: http://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/.
[3] Velavan TP, Pallerla SR, Johne R, Todt D, Steinmann E, Schemmerer M, et al. Hepatitis E: An update on One Health and clinical medicine. Liver Int. 2021; 41 (7): 1462-1473.
[4] Kirkwood CD, Dobscha KR, Steele AD. Hepatitis E should be a global public health priority: recommendations for improving surveillance and prevention. Expert Rev Vaccines 2020; 19 (12): 1129-1140.
[5] Johne R, Dremsek P, Reetz J, Heckel G, Hess M, Ulrich RG. Hepeviridae: an expanding family of vertebrate viruses. Infect Genet Evol. 2014; 27: 212-229.
[6] Reuter G, Boros Á, Pankovics P. Review of Hepatitis E Virus in Rats: Evident Risk of Species Orthohepevirus C to Human Zoonotic Infection and Disease. Viruses. 2020; 12 (10): 1148.
[7] Sridhar S, Yip CCY, Wu S, Cai J, Zhang AJ, Leung KH, et al. Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant. Emerg Infect Dis. 2018; 24 (12): 2241-2250.
[8] Andonov A, Robbins M, Borlang J, et al. Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient. J Infect Dis. 2019;220(6):951-955.
[9] Sridhar S, Yip CC, Wu S, Chew NF, Leung KH, Chan JF, et al. Transmission of Rat Hepatitis E Virus Infection to Humans in Hong Kong: A Clinical and Epidemiological Analysis. Hepatology. 2021; 73 (1): 10-22.
[10] Sridhar S, Yip CC, Lo KH, Wu S, Situ J, Chew NF, et al. Hepatitis E virus species C infection in humans, Hong Kong. Clin Infect Dis. 2021: Epub ahead of print. doi: 10.1093/cid/ciab919.
[11] Wang B, Harms D, Yang XL, Bock CT. Orthohepevirus C: An Expanding Species of Emerging Hepatitis E Virus Variants. Pathogens. 2020;9(3):154.
[12] Rivero-Juarez A, Frias M, Perez AB, et al. Orthohepevirus C infection as an emerging cause of acute hepatitis in Spain: First report in Europe [published online ahead of print]. J Hepatol. 2022;S0168-8278(22)00075-7. doi:10.1016/j.jhep.2022.01.028
[13] Drave SA, Debing Y, Walter S, et al. Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. J Viral Hepat. 2016;23(7):512-521.
[14] Dalton H, van Eijk JJJ, Cintas P, et al. Hepatitis E virus infection and acute non-traumatic neurological injury: a prospective multicentre study. Journal of Hepatology 2017; 67: 925-932
[15] Sridhar S, Situ J, Cai JP, Yip CC, Wu S, Zhang AJ, et al. Multimodal investigation of rat hepatitis E virus antigenicity: Implications for infection, diagnostics, and vaccine efficacy. J Hepatol. 2021; 74 (6): 1315-1324.
[16] Reuter G, Boros Á, Pankovics P. Review of Hepatitis E Virus in Rats: Evident Risk of Species Orthohepevirus C to Human Zoonotic Infection and Disease. Viruses. 2020; 12 (10): 1148.
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Rivero-Juárez A, Frías M, Rivero A. Orthohepevirus C as causal agent of acute hepatitis in Spain. 8993/2022


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Publication history

Received: 08/06/2022

Accepted: 19/06/2022

Online First: 07/10/2022

Published: 07/11/2022

Article Online First time: 121 days

Article editing time: 152 days


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