Year 2019 / Volume 111 / Number 10
Original
The use of serum calprotectin as a biomarker for inflammatory activity in inflammatory bowel disease

744-749

DOI: 10.17235/reed.2019.5797/2018

Cristina Suárez Ferrer, Marta Abadía Barno, Eduardo Martín Arranz, Andrea Jochems, Laura García Ramírez, Joaquín Poza Cordón, Marta Jaquotot Herranz, Alberto Cerpa Arencibia, María Dolores Martín Arranz,

Abstract
Introduction: simple, reliable and non-invasive biomarkers are needed to enable the early detection of inflammatory activity for the correct management of inflammatory bowel disease (IBD). One of these biomarkers may be serum calprotectin (SC). Material and methods: a prospective study was performed of patients with IBD due to undergo a colonoscopy as part of the common clinical practice. The study parameters included SC, fecal calprotectin (FC) and conventional blood test parameters. Clinical indices (Harvey and Walmsley) and relevant endoscopic scores were completed for each scenario (Simple Endoscopic Score Crohn Disease [SES-CD] and Mayo). Results: fifty-three patients were included in the study, 51% (27 patients) with ulcerative colitis (UC) and 49% (26 patients) with Crohn’s disease (CD). The CS values in UC were significantly higher with an endoscopic Mayo score 2/3 (median score 10.39 mg/ml [IQR: 7.4-12.2]) compared to those with a Mayo score of 0/1 (median 4.07 mg/ml [IQR: 2.9-7.2]) (p = 0.01). The area under the ROC curve (AUCROC) was 0.85 and the sensitivity and specificity were 83.3% and 81.25%, respectively, for a SC cut-off point of 4.4 mg/dl. Furthermore, a higher AUCROC was obtained in comparison with other serological markers for activity (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], hemoglobin [Hb] and platelets). There were no statistically significant differences in the comparison between SC and endoscopic findings in CD (SES CD > 3: 20.1 [IQR: 16.8-23.4] vs SESC ≤ 3:6.25 [IQR: 5.4-7.1]) (p = 0.8). Conclusions: SC is a good indirect marker of inflammatory activity and there was a correlation with endoscopic findings in UC. However, there were no statistically significant differences in the case of CD.
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Suárez Ferrer C, Abadía Barno M, Martín Arranz E, Jochems A, García Ramírez L, Poza Cordón J, et all. The use of serum calprotectin as a biomarker for inflammatory activity in inflammatory bowel disease. 5797/2018


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Publication history

Received: 26/06/2018

Accepted: 17/03/2019

Online First: 03/09/2019

Published: 03/10/2019

Article revision time: 258 days

Article Online First time: 434 days

Article editing time: 464 days


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