Año 2024 / Volumen 116 / Número 4
Carta
The significance of appendectomy in the context of colorectal cancer: impacts on gut microbiota and beyond

224-225

DOI: 10.17235/reed.2023.9657/2023

Yunzhen Lin, Tianhang Li,

Resumen
Colorectal cancer (CRC) remains one of the most common malignancies globally, of which the initiative factors are multiple and complex. More recently, the major roles played by gut microbiota in the carcinogenesis of CRC have been uncovered, which indicates that dysbiosis caused by specific bacterial or fungal species may contribute to the malignant progression of CRC. Meanwhile, appendix, classically identified as an evolutionary relict with negligible physiological functions, has been found to play crucial roles in the immune modulation process and microbiome composition of gut by its lymphoid tissue features. In addition, appendectomy, a common surgical operation modality, has also been found to be closely correlated with the clinical outcomes of multiple diseases, including CRC. Naturally, these evidence collectively point to a possibility that the appendectomy may influence the pathological process of CRC through its impacts on gut microbiome.
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Bibliografía
1. Shi F, Liu G, Lin Y, et al. Altered gut microbiome composition by appendectomy contributes to colorectal cancer. Oncogene. 2023;42(7):530-540. doi:10.1038/s41388-022-02569-3
2. Bender MJ, McPherson AC, Phelps CM, et al. Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment [published online ahead of print, 2023 Apr 4]. Cell. 2023;S0092-8674(23)00271-4. doi:10.1016/j.cell.2023.03.011
3. Lu Y, Yuan X, Wang M, et al. Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies. J Hematol Oncol. 2022;15(1):47. Published 2022 Apr 29. doi:10.1186/s13045-022-01273-9
4. Wang T, Fan C, Yao A, et al. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 2018;49(3):504-514.e4. doi:10.1016/j.immuni.2018.08.018
5. Malik A, Sharma D, Malireddi RKS, et al. SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. Immunity. 2018;49(3):515-530.e5. doi:10.1016/j.immuni.2018.08.024
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Lin Y, Li T. The significance of appendectomy in the context of colorectal cancer: impacts on gut microbiota and beyond. 9657/2023


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Ficha Técnica

Recibido: 11/04/2023

Aceptado: 17/04/2023

Prepublicado: 28/04/2023

Publicado: 09/04/2024

Tiempo de prepublicación: 17 días

Tiempo de edición del artículo: 364 días


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