Year 2017 / Volume 109 / Number 10
Letter to the Editor
Hepatocellular carcinoma in patients without advanced fibrosis after HCV eradication antiviral treatment

734-735

DOI: 10.17235/reed.2017.4677/2016

Yolanda Sánchez-Torrijos, Jara Eloísa Ternero Vega, Carmen Cepeda Franco,

Abstract
From the last few years, hepatitis C virus and the new direct antiviral treatments are being more and more important. In consequence, case studies like the one we present, the appearance of hepatocelullar carcinoma after its eradication with fibrosis grade 2, are getting special interest. In 2007, our patient was treated with pegylated interferon α-2a and ribavirin, having a sustained virological response after it. In this way, liver fibrosis grade 2 was confirmed by a biopsy. Finally, after corroborating a good liver functioning, the patient was discharged (as, according to the guidebooks, an ultrasound scan of screeing every 6 months was not required). In 2014, the patient came to hospital because of a pain at right hypochondrium and he was diagnosed with hepatocelullar carcinoma. A hepatectomy was done objectifying the surgical piece, liver fibrosis grade 2, one more time. Subsequently, a tumour relapse through an abdominal CT scan, a tumour relapse was found and despite the Sorafenib treatment, the patient died on January 2015. This case study provokes curiosity and uncertainty about the attitude which should be taken respect to the monitoring, and hepatocelullar carcinoma screening overall, in patients with a sustained virological response after eradicator treatment and without advanced fibrosis. Nowadays, with the benefits of the new treatments, the amount of patients in this situation is increasing significantly.
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References
1. Yamashita N, Ohho A, Yamasaki A et al. Hepatocarcinogenesis in chronic hepatitis C patients achieving a sustained virological response to interferon: significance of lifelong periodic cancer screening for improving outcomes. J Gastroenterol 2014; 49: 1504-1513.
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Sánchez-Torrijos Y, Ternero Vega J, Cepeda Franco C. Hepatocellular carcinoma in patients without advanced fibrosis after HCV eradication antiviral treatment. 4677/2016


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Publication history

Received: 17/10/2016

Accepted: 12/04/2017

Online First: 04/08/2017

Published: 29/09/2017

Article revision time: 172 days

Article Online First time: 291 days

Article editing time: 347 days


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