Year 2017 / Volume 109 / Number 6
Letter to the Editor
Genetics in idiopathic pancreatitis and acute recurrent pancreatitis

478-479

DOI: 10.17235/reed.2017.4632/2016

Sandra Martínez-Barona, Carmen Ribes-Koninckx,

Abstract
Acute recurrent pancreatitis (ARP) occurs in 10-35% of children presenting idiopathic acute pancreatitis (IAP) and can evolve to chronic pancreatitis (CP), especially if genetic mutations are present.
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References
1. Poddar U, Kumar Yachha S, Mathias A et al. Genetic predisposition and its impact on natural history of idiopathic acute and acute recurrent pancreatitis in children. Dig Liver Dis. 2015;47:709-14.
2. Witt H, Luck W, Hennies HC, et al. Mutations in the gene encoding the serine protease inhibitor Kajal type I are assocciated with chronic pancreatitis. Nat Genet. 2000;25:213-6.
3. Sobczynska-Tomaszewska A, Bak D, Oralewska B, et al. Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. J Pediatr Gastroenterol Nutr. 2006;43:299-306.
4. Lee YJ, Kim KM, Choi JH, et al. High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr. 2011;52:478–81.
5. Schwarzenberg SJ, Bellin M, Housain SZ, et al. Pediatric Chronic Pancreatitis Is Associated with Genetic Risk Factors and Substantial Disease Burden. J Pediatr. 2015;166:890-6.
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Martínez-Barona S, Ribes-Koninckx C. Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. 4632/2016


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Publication history

Received: 23/09/2016

Accepted: 18/10/2016

Online First: 23/02/2017

Published: 01/06/2017

Article revision time: 15 days

Article Online First time: 153 days

Article editing time: 251 days


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