Year 2017 / Volume 109 / Number 10
Original
Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method

694-703

DOI: 10.17235/reed.2017.4645/2016

José Manuel Navarro Rodríguez, Javier Gallego Plazas, Fernando Borrás Rocher, Rafael Calpena Rico, José Antonio Ruiz Macia, Miguel Ángel Morcillo Ródenas,

Abstract
Introduction: The assessment of the state of immunosurveillance (the ability of the organism to prevent the development of neoplasias) in the blood has prognostic implications of interest in colorectal cancer. We evaluated and quantified a possible predictive character of the disease in a blood test using a mathematical interaction index of several blood parameters. The predictive capacity of the index to detect colorectal cancer was also assessed. Methods: We performed a retrospective case-control study of a comparative analysis of the distribution of blood parameters in 266 patients with colorectal cancer and 266 healthy patients during the period from 2009 to 2013. Results: Statistically significant differences (p < 0.05) were observed between patients with colorectal cancer and the control group in terms of platelet counts, fibrinogen, total leukocytes, neutrophils, systemic immunovigilance indexes (neutrophil to lymphocyte ratio and platelet to lymphocyte ratio), hemoglobin, hematocrit and eosinophil levels. These differences allowed the design of a blood analytical profile that calculates the risk of colorectal cancer. This risk profile can be quantified via a mathematical formula with a probabilistic capacity to identify patients with the highest risk of the presence of colorectal cancer (area under the ROC curve = 0.85). Conclusions: We showed that a colorectal cancer predictive character exists in blood which can be quantified by an interaction index of several blood parameters. The design and development of interaction indexes of blood parameters constitutes an interesting research line for the development and improvement of programs for the screening of colorectal cancer.
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References
1.- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65:5
2.- International Agency for Research on Cancer (World Health Organization), GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. Disponible en: http://globocan.iarc.fr/Default.aspx (accedido el 1/10/2015)
3.- Sociedad Española de Oncología Médica (SEOM). Disponible en: http://www.seom.org (accedido el 30/09/2015)
4.- Winawer SJ, Fletcher RH, Miller L, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology 1997; 112:594
5.- Red de programas de cribado de cáncer: Guia de control de calidad en cribado y diagnóstico de cáncer colorrectal. Disponible en: http://www.programascancerdemama.org/index.php/guia-europea-colon (accedido el 11/10/2015)
6.- European Commission, Public Health. Disponible en: http://ec.europa.eu/health/ph_determinants/genetics/documents/cancer_screening.pdf (accedido el 12/10/2015)
7.- European Commission, Public Health. Disponible en: http://ec.europa.eu/health/ph_determinants/genetics/documents/com_2008_882.en.pdf (accedido el 12/10/2015)
8.- Rex DK, Johnson DA, Anderson JC, et al. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol. 2009 Mar;104(3):739-50.
9.- Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010 Jun;17(6):1471-4 DOI: 10.1245/s10434-010-0985-4
10.- GENERALITAT VALENCIANA (www.san.gva.es). Programa de prevención del cáncer colorrectal en la Comunidad Valenciana. Disponible en: http://publicaciones.san.gva.es/publicaciones/documentos/V.3849-2009.pdf (accedido el 15/10/2015)
11.- Red de programas de cribado de cáncer: Cáncer colorrectal. http://www.programascancerdemama.org/index.php/cancer-colorrectal/red-de-programas-de-cribado-espanoles
12.- Red de programas de cribado de cáncer: El cribado del cáncer de colon en España, Situación 2006-2014. Disponible en: http://www.programascancerdemama.org/images/archivos/colorrectal/situacion/Implantacion%20CCCR%20en%20Espa%C3%B1a%202014.pdf (accedido el 11/10/2015)
13.- Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours. J Pathol 2014; 232:199
14.- Park JH, Richards CH, McMillan DC, et al. The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer. Ann Oncol 2014; 25:644
15.- Paik K, Lee I, Lee Y, et al. Clinical implications of systemic inflammatory response markers as independent prognostic factors in colorectal cancer patients. Cancer Res Treat 2014; 46:65
16.- Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature 2008; 454:436
17.- Paik K, Lee I, Lee Y, et al. Clinical implications of systemic inflammatory response markers as independent prognostic factors in colorectal cancer patients. Cancer Res Treat 2014; 46:65
18.- Kozak MM, von Eyben R, Pai JS, et al. The Prognostic Significance of Pretreatment Hematologic Parameters in Patients Undergoing Resection for Colorectal Cancer. Am J Clin Oncol 2015; 3:11
19.- Ozdemir Y, Akin M, Sucullu I, et al. Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer. Asian Pac J Cancer Prev 2014; 15:2647
20.- Arnoud J, Templeton J, Olga A, et al. Prognostic Role of Platelet to Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis. Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1204-12. doi: 10.1158/1055-9965.
21.- McMillan DC. The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer. Cancer Treatment Reviews 2013; 39:534
22.- Prizment A, Anderson K, Visvanathan K, et al. Inverse association of eosinophil count with colorectal cancer incidence: atherosclerosis risk in communities study. Cancer Epidemiol Biomarkers Prev 2011; 20:1861
23.- Bewick V, Cheek L, Ball J. Statistics review 13: Receiver operating characteristic curves. Critical Care. 2004;8(6):508-512. doi:10.1186/cc3000.
24.- Vendramini DB, Carvalho JE. Molecular link mechanisms between inflammation and cancer. Curr Pharm Des 2012; 18:3831
25.- Chen S, Huang E. The colon cancer stem cell microenvironment holds keys to future cancer therapy. J Gastrointest Surg 2014; 18:1040
26.- Engkilde K, Thyssen J, Menne T, et al. Association between cancer and contact allergy: a linkage study. BMJ Open 2011; 10:1136
27.- Laird B, Kaasa S, McMillan D, et al. Prognostic factors in patients with advanced cancer: a comparison of clinicopathological factors and the development of an inflammation-based prognostic system. Clin Cancer Res 2013; 19: 5456
28.- Costantino J, Gail M, Pee D, et al. Validation studies for models projecting the risk of invasive and total breast cancer incidence. J Natl Cancer Inst 1999; 91:1541
29.- Gomez F. Evaluación cuantitativa del riesgo de cáncer de mama. Rev Med Clin Condes 2006; 17:149. http://dx.doi.org/10.1016/S0716-8640(13)70198-6
30.- Anderson D, Najafzadeh M, Gopalan R, et al. Sensitivity and specificity of the empirical lymphocyte genome sensitivity (LGS) assay: implications for improving cancer diagnostics. FASEB J 2014; 28:4563
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Navarro Rodríguez J, Gallego Plazas J, Borrás Rocher F, Calpena Rico R, Ruiz Macia J, Morcillo Ródenas M, et all. Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method. 4645/2016


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Publication history

Received: 02/10/2016

Accepted: 24/05/2017

Online First: 18/09/2017

Published: 29/09/2017

Article revision time: 230 days

Article Online First time: 351 days

Article editing time: 362 days


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