References
1. Alberti KG, Zimmet P, Shaw J. The metabolic syndrome--a new worldwide definition. Lancet. 2005;366(9491):1059-62.
2. McNeill AM, Rosamond WD, Girman CJ, et al. The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study. Diabetes care. 2005;28(2):385-90.
3. McCullough AJ. Epidemiology of the metabolic syndrome in the USA. Journal of digestive diseases. 2011;12(5):333-40.
4. Zimmet P, Magliano D, Matsuzawa Y, et al. The metabolic syndrome: a global public health problem and a new definition. Journal of atherosclerosis and thrombosis. 2005;12(6):295-300.
5. Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Annals of internal medicine. 2005;143(10):722-8.
6. Almeda-Valdes P, Cuevas-Ramos D, Aguilar-Salinas CA. Metabolic syndrome and non-alcoholic fatty liver disease. Annals of hepatology. 2009;8 Suppl 1:S18-24.
7. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-7.
8. Wree A, McGeough MD, Pena CA, et al. NLRP3 inflammasome activation is required for fibrosis development in NAFLD. Journal of molecular medicine (Berlin, Germany). 2014;92(10):1069-82.
9. Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. The Journal of clinical investigation. 2006;116(11):3015-25.
10. Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes. 2007;56(8):1986-98.
11. Kim F, Pham M, Luttrell I, et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circulation research. 2007;100(11):1589-96.
12. Nguyen MT, Favelyukis S, Nguyen AK, et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. The Journal of biological chemistry. 2007;282(48):35279-92.
13. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124(4):783-801.
14. Beutler BA. TLRs and innate immunity. Blood. 2009;113(7):1399-407.
15. Beutler B. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunol Rev. 2007;220:113-28.
16. Pimentel-Nunes P, Goncalves N, Boal-Carvalho I, et al. Decreased Toll-interacting protein and peroxisome proliferator-activated receptor gamma are associated with increased expression of Toll-like receptors in colon carcinogenesis. Journal of clinical pathology. 2012;65(4):302-8.
17. Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology. 2002;123(1):134-40.
18. Lopes JA, Borges-Canha M, Pimentel-Nunes P. Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis? World journal of hepatology. 2016;8(3):162-82.
19. Soares JB, Pimentel-Nunes P, Roncon-Albuquerque R, et al. The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases. Hepatology international. 2010;4(4):659-72.
20. Soares JB, Pimentel-Nunes P, Afonso L, et al. Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence. Innate immunity. 2012;18(5):700-8.
21. Tofovic SP, Kusaka H, Jackson EK, et al. Renal and metabolic effects of caffeine in obese (fa/fa(cp)), diabetic, hypertensive ZSF1 rats. Renal failure. 2001;23(2):159-73.
22. Hamdani N, Franssen C, Lourenco A, et al. Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model. Circulation Heart failure. 2013;6(6):1239-49.
23. Tofovic SP, Kusaka H, Kost CK, et al. Renal function and structure in diabetic, hypertensive, obese ZDFxSHHF-hybrid rats. Renal failure. 2000;22(4):387-406.
24. Tofovic SP, Dubey R, Salah EM, et al. 2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy. Journal of the American Society of Nephrology : JASN. 2002;13(11):2737-47.
25. Tofovic SP, Kost CK, Jr., Jackson EK, et al. Long-term caffeine consumption exacerbates renal failure in obese, diabetic, ZSF1 (fa-fa(cp)) rats. Kidney international. 2002;61(4):1433-44.
26. Bilan VP, Salah EM, Bastacky S, et al. Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats. The Journal of endocrinology. 2011;210(3):293-308.
27. Zambad SP, Munshi S, Dubey A, et al. TRC150094 attenuates progression of nontraditional cardiovascular risk factors associated with obesity and type 2 diabetes in obese ZSF1 rats. Diabetes, metabolic syndrome and obesity : targets and therapy. 2011;4:5-16.
28. Leite S, Rodrigues S, Tavares-Silva M, et al. Afterload-induced diastolic dysfunction contributes to high filling pressures in experimental heart failure with preserved ejection fraction. American journal of physiology Heart and circulatory physiology. 2015;309(10):H1648-54.
29. Conceicao G, Heinonen I, Lourenco AP, et al. Animal models of heart failure with preserved ejection fraction. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation. 2016;24(4):275-86.
30. Roullier V, Cavaro-Menard C, Guillaume C, et al. Fuzzy algorithms to extract vacuoles of steatosis on liver histological color images. Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2007;2007:5575-8.
31. Marques CM, Motta VF, Torres TS, et al. Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica [et al]. 2010;43(5):467-75.
32. Ishii Y, Motohashi Y, Muramatsu M, et al. Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions. World J Gastroenterol. 2015;21(30):9067-78.
33. Asgharpour A, Cazanave SC, Pacana T, et al. A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. Journal of hepatology. 2016.
34. Li D, Wang X, Lan X, et al. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Molecular and cellular endocrinology. 2015;402:1-12.
35. Ye D, Li FY, Lam KS, et al. Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut. 2012;61(7):1058-67.
36. Kawanishi N, Yano H, Mizokami T, et al. Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice. Brain, behavior, and immunity. 2012;26(6):931-41.
37. Cong WN, Tao RY, Tian JY, et al. The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. Life sciences. 2008;82(19-20):983-90.
38. Sakr HF, Al-Hashem FH, El-Naby WM, et al. Preventive roles of swimming exercise and pioglitazone treatment on hepatic dysfunction in a rat model of metabolic syndrome. Canadian journal of physiology and pharmacology. 2014;92(2):162-70.
39. Kapravelou G, Martinez R, Andrade AM, et al. Aerobic interval exercise improves parameters of nonalcoholic fatty liver disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2015;40(12):1242-52.
40. Cameron I, Alam MA, Wang J, et al. Endurance exercise in a rat model of metabolic syndrome. Canadian journal of physiology and pharmacology. 2012;90(11):1490-7.
41. Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005;19(1):136-8.