Year 2020 / Volume 112 / Number 6
Original
The relationship between integrin avß6 and HBV infection in patients with liver cirrhosis and hepatocellular carcinoma: a preliminary report

462-466

DOI: 10.17235/reed.2020.6607/2019

Zhao-Bin He, Wei-Bo Niu, Cheng Peng, Chao Gao, Hui-Jie Gao, Jun Niu,

Abstract
Objective: the aim of this study was to investigate the expression of integrin αvβ6 in normal, hepatitis B, HBV-associated cirrhosis and HBV-associated HCC liver tissues. Methods: immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) were used to study the expression of integrin αvβ6 in HBV-associated cirrhosis (n = 88), chronic hepatitis B ( n= 11), HBV-associated HCC (n = 84) and normal (n = 10) human liver tissues. Results: the expression of integrin αvβ6 was significantly upregulated in HBV-associated liver cirrhosis and the expression increased with an increase in severity of cirrhosis. Furthermore, it was moderately or weakly expressed in chronic hepatitis B and HBV-associated HCC liver tissues when compared to normal liver tissue. Conclusion: integrin αvβ6 could be a predictive marker for the progression of liver cirrhosis associated with HBV infection. Further studies are needed to determine the association between the expression of integrin αvβ6 in hepatitis B and HBV-associated HCC liver tissues.
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He Z, Niu W, Peng C, Gao C, Gao H, Niu J, et all. The relationship between integrin avß6 and HBV infection in patients with liver cirrhosis and hepatocellular carcinoma: a preliminary report. 6607/2019


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Publication history

Received: 03/09/2019

Accepted: 13/12/2019

Online First: 26/05/2020

Published: 08/06/2020

Article revision time: 90 days

Article Online First time: 266 days

Article editing time: 279 days


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