Year 2021 / Volume 113 / Number 10
Letter
Leflunomide as a cause of collagenous colitis: an entity to consider

735

DOI: 10.17235/reed.2021.8015/2021

Paulina Núñez, Rodrigo Quera, Lilian Flores, Luis Contreras,

Abstract
Leflunomide belongs in the group of disease-modifying anti-rheumatic drugs (DMARDs) used in the treatment of psoriatic, rheumatoid, and reactive arthritis. Approximately 20 % of patients will experience some adverse event, mainly weight loss, abdominal pain, and diarrhea. We describe the clinical, endoscopic, and histological findings in a patient with psoriatic arthritis (PA) who developed severe chronic diarrhea after drug use.
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References
1. Verschueren P, Vandooren AK, Westhovens R. Debilitating diarrhea and weight loss due to colitis in two RA patients treated with leflunomide. Clin Rheumatol 2005; 24: 87-90
2. Gugenberger C, Donner P, Maami A, et al. Pesistent diarrhea and loss of weight during therapy with leflunomide. Dtsch Med Wochenschr 2008;133:1730-2
3. Kwok AMF, Morosin T. Leflunomide-induced colitis in association with enterocutaneous fistula in an immunosuppressed patient with renal and rheumatoid arthritis. J gastroenterol 2019;12:310-5. doi: 10.1007/s12328-019-00954-2
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Núñez P, Quera R, Flores L, Contreras L. Leflunomide as a cause of collagenous colitis: an entity to consider . 8015/2021


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Publication history

Received: 02/04/2021

Accepted: 10/04/2021

Online First: 19/04/2021

Published: 06/10/2021

Article Online First time: 17 days

Article editing time: 187 days


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