Year 2022 / Volume 114 / Number 6
Editorial
Everolimus versus mycophenolate mofetil in liver transplantation: every improvement in renal function matters

312-313

DOI: 10.17235/reed.2022.8902/2022

Paolo De Simone, Jessica Bronzoni, Caterina Martinelli,

Abstract
The current edition of the journal features a Spanish, nationwide, multi-institutional study by Gomez Bravo MA et al. exploring the advantages of everolimus (EVR)-facilitated tacrolimus (TAC) minimization versus TAC in combination with mycophenolate mofetil (MMF) after liver transplantation (LT).
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References
1. Gomez Bravo MA, Prieto M, Navasa M, et al. Everolimus plus minimized tacrolimus on kidney function in liver transplantation: REDUCE, a prospective, randomized controlled study. Rev Esp Enf Dig 2022, in press.
2. De Simone P, Nevens F, De Carlis L, et al. Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial. Am J Transplant 2012;12(11):3008-3020.
3. Jeng LB, Lee SG, Soin AS, et al. Efficacy and safety of everolimus with reduced tacrolimus in living-donor liver transplant recipients: 12-month results of a randomized multicenter study. Am J Transplant 2017;18(6):1435-1446.
4. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int, Suppl. 2013; 3: 1–150.
5. Allen AM, Kim WR, Therneau TM, et al. Chronic kidney disease and associated mortality after liver transplantation – a time-dependent analysis using measured glomerular filtration rate. J Hepatol 2014;61(2):286-92.
6. Fischer L, Klempnauer J, Beckebaum S, et al. A randomized, controlled study to assess the conversion from calcineurin-inhibitors to everolimus after liver transplantation-PROTECT. Am J Transplant 2012;12(7):1855-1865.
7. Sterneck M, Kaiser GM, Heyne N, et al. Everolimus and early calcineurin inhibitor withdrawal: 3-year results from a randomized trial in liver transplantation. Am J Transplant 2014;14(3):701-710.
8. Sterneck M, Kaiser GM, Heyne N, et al. Long-term follow-up of five yr shows superior renal function with everolimus plus early calcineurin inhibitor withdrawal in the PROTECT randomized liver transplantation study. Clin Transplant 2016;30(6):741-748.
9. De Simone P, Carrai P, Coletti L, et al. Everolimus vs mycophenolate mofetil in combination with tacrolimus: a propensity score-matched analysis in liver transplantation. Transplant Proc 2018;50(10):3615-3620.
10. Tedesco-Silva H, Saliba F, Barten MJ, et al. An overview of the efficacy and safety of everolimus in adult solid organ transplant recipients. Transplant Rev (Orlando) 2022; 36(1):100655.
11. Lassailly G, Dumortier J, Saint-Marcoux F, et al. Real life experience of mycophenolate mofetil monotherapy in liver transplant patients. Clin Res Hepatol Gastroenterol 2021; 45(1):101451.
12. Norero B, Serrano CA, Sanchez-Fueyo A, et al. Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key. Ann Hepatol 2017; 16(1):94-106.
13. Cruz CM, Pereira S, Gandara J, et al. Efficacy and safety of monotherapy with mycophenolate mofetil in liver transplantation patients with nephrotoxicity. Transplant Proc 2016; 48(7): 2341-3.
14. Holdaas H, De Simone P, Zuckermann A. Everolimus and malignancy after solid organ transplantation: A clinical update. J Transplant 2016; 2016:4349574.
15. Ferrín G, Guerrero M, Amado V, et al. Activation of mTOR signaling pathway in hepatocellular carcinoma. Int J Mol Sci 2020; 21(4):E1266.
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De Simone P, Bronzoni J, Martinelli C. Everolimus versus mycophenolate mofetil in liver transplantation: every improvement in renal function matters . 8902/2022


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Publication history

Received: 02/05/2022

Accepted: 03/05/2022

Online First: 12/05/2022

Published: 07/06/2022

Article Online First time: 10 days

Article editing time: 36 days


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