Year 2024 / Volume 116 / Number 1
Original
Dried lemon slices improve bowel cleansing quality of polyethylene glycol for colonoscopy preparation: randomized controlled trial

7-13

DOI: 10.17235/reed.2023.9676/2023

Xiawei Huang, Liping Yang, Yingbo Lyu, Han Ma, Xiaoli Zhou, Kexin Ye, Jiehui Feng,

Abstract
Background: adequate bowel preparation is related to the quality of colonoscopy. Dried lemon slices can increase gastrointestinal peristalsis, which has shown potential as an adjuvant of bowel preparation. We hypothesized that the combination of dried lemon slices and polyethylene glycol (PEG) could improve the efficacy of bowel preparation and be more acceptable to participants. Aim: to investigate the effectiveness of lemon slices combined with PEG for colonoscopy preparation. Methods: a prospective, single-center, randomized, controlled trial was performed of 521 patients randomly assigned to two groups. A total of 254 patients were given lemon slices based on conventional 4-L PEG treatment for the bowel, while 267 patients received only 4-L PEG treatment. Patients’ basic information, procedure-related parameters, adverse effects, and subjective feelings were collected by questionnaires. Intestinal tract cleanliness was scored according to the Boston Bowel Preparation Scale (BBPS) by experienced endoscopists. Data were analyzed by the two-sample t-test or the Chi-squared test. Results: the BBPS scores were significantly higher in the PEG + lemon slice group (p < 0.05). The taste acceptability, satisfaction, and willingness to repeat bowel preparation were significantly higher in the PEG+ lemon slice group (p < 0.05). However, a larger proportion of patients from the PEG+ lemon slice group (30.7 %) suffered abdominal distension compared with the PEG group (20.6 %), while the incidence of other adverse effects was comparable between the two groups. Conclusion: the addition of dried lemon slices to conventional PEG showed its superiority for bowel preparation.
Lay Summary
Colonoscopy is widely used in clinical practice, however, many patients suffer from the bowel preparation process before colonoscopy. This study aimed to investigate the effectiveness of lemon slices combined with PEG for colonoscopy preparation, which could possibly improve the taste of laxatives and make patients feel better during the process. We randomly divided participants into two group to receive conventional bowel preparation formula and a new formula with lemon slices separately. The bowel preparation quality, adverse effects and patients’ objective feelings were evaluated during or after the process. The application of lemon slices combined with conventional polyethylene glycol treatment provided a novel method for bowel preparation with higher quality of bowel cleanness compared with conventional treatment. In addition, it improved the taste of laxatives and showed higher acceptability. Hence, it is a practical and simple bowel preparation method demonstrating its potential in clinical practice.
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Huang X, Yang L, Lyu Y, Ma H, Zhou X, Ye K, et all. Dried lemon slices improve bowel cleansing quality of polyethylene glycol for colonoscopy preparation: randomized controlled trial. 9676/2023


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Publication history

Received: 19/04/2023

Accepted: 06/07/2023

Online First: 04/08/2023

Published: 11/01/2024

Article revision time: 71 days

Article Online First time: 107 days

Article editing time: 267 days


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