Year 2021 / Volume 113 / Number 2
Letter
Hepatitis C and beta-thalassemia major in children: experience with glecaprevir/pibrentasvir

150-151

DOI: 10.17235/reed.2020.7092/2020

Diannet Quintero García, Francisco José Sebastián Cuevas, Elena Crehuá Gaudiza,

Abstract
Hepatitis C virus (HCV) is estimated to affect 3.26 million children worldwide, with the highest number of cases registered in Pakistan and China. Vertical transmission is the principal route in industrialized countries. However, iatrogenic transmission is relevant in low-income settings. We present the case of a 12-year-old Pakistani child who suffered from beta-thalassemia major and hepatitis C, successfully treated with glecaprevir/pibrentasvir.
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References
1. Polaris Observatory HCV Collaborators. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. Lancet Gastroenterol Hepatol 2017;2(3):161-176.
2. Kamal S, Abdelhakam S, Ghoraba D, et al. The Course of Hepatitis C Infection and Response to Anti-viral Therapy in Patients with Thalassemia major and Hepatitis C Infection: A Longitudinal, Prospective Study. Mediterr J Hematol Infect Dis 2019;11(1):e2019060.
3. Indolfi G, Easterbrook P, Dusheiko G, et al. Hepatitis C virus infection in children and adolescents. Lancet Gastroenterol Hepatol 2019;4(6):477-487.
4. Wyles D, Poordad F, Wang S, et al. Glecaprevir/pibrentasvir for hepatitis C virus genotype 3 patients with cirrhosis and/or prior treatment experience: a partially randomized phase 3 clinical trial: viral hepatitis. Hepatology 2018;67(2):514-523.
5. Jonas MM, Squires RH, Rhee S, et al. Pharmacokinetics, safety, and efficacy of glecaprevir/pibrentasvir in adolescents with chronic hepatitis C virus: part 1 of the DORA study. Hepatology 2020;71(2):456-462.
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Quintero García D, Sebastián Cuevas F, Crehuá Gaudiza E. Hepatitis C and beta-thalassemia major in children: experience with glecaprevir/pibrentasvir. 7092/2020


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Publication history

Received: 31/03/2020

Accepted: 12/04/2020

Online First: 19/11/2020

Published: 08/02/2021

Article revision time: 7 days

Article Online First time: 233 days

Article editing time: 314 days


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