Year 2023 / Volume 115 / Number 11
Letter
Blue rubber bleb nevus syndrome

671

DOI: 10.17235/reed.2023.9913/2023

Adriana Ortega Larrodé, Lonore Hurtado de Mendoza, Sara Mata Casado, Omar Hebert Palomino Donayre, Leonardo Blas Jhon, Sergio Farrais Villalba, Juan Carlos Porres Cubero,

Abstract
Gastrointestinal bleeding of obscure origin accounts for less than 5% of gastrointestinal hemorrhages. It is typically difficult to diagnose due to limited accessibility through standard endoscopic techniques and generally requires a significant number of procedures to reach a diagnosis. The "blue rubber bleb nevus syndrome” is a rare condition, of a probably hereditary origin, characterized by the presence of multiple hemangiomatous lesions, which can manifest as gastrointestinal bleeding of obscure origin. These lesions are generally nodular, rubbery to the touch, and have a submucosal appearance, primarily affecting the skin and gastrointestinal tract. We present the case of a 72-year-old male who was investigated for iron deficiency anemia with upper and lower gastrointestinal endoscopies conducted on two occasions, without revealing any findings that could explain the condition. Subsequently, a study with video-capsule endoscopy was performed, which revealed multiple submucosal and vascular lesions, measuring between 3-5 mm, located in the distal duodenum and jejunum, consistent with "Blue rubber bleb nevus syndrome”.
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References
1. Laube R, Rickard M, Lee AU. Gastrointestinal: Small intestinal blue rubber bleb nevus syndrome. J Gastroenterol Hepatol. 2021 Oct;36(10):2637. doi: 10.1111/jgh.15422. Epub 2021 Feb 18. PMID: 33601477.
2. Gawlikowska-Sroka A, Glura B, Mokrzycka M, Ociepa T. [Bean Syndrome (blue rubber bleb nevus syndrome)]. Pomeranian J Life Sci. 2016;62(2):5-7. Polish. PMID: 29537205.
3. Xia H, Wu J, Huang Y. Blue rubber bleb nevus syndrome: a single-center case series in 12 years. Transl Pediatr. 2021 Nov;10(11):2960-2971. doi: 10.21037/tp-21-238. PMID: 34976762; PMCID: PMC8649602.
4. Mascarenhas Saraiva M, Ribeiro T, Andrade P, Cardoso H, Macedo G. Capsule enteroscopy versus radionuclide scintigraphy for the diagnosis of obscure gastrointestinal bleeding. Rev Esp Enferm Dig. 2022 Apr;114(4):208-212. doi: 10.17235/reed.2021.7633/2020. PMID: 34015932.
5. Melo Valadão I, Benites MG. An unusual cause of anemia: Bean syndrome. Rev Esp Enferm Dig. 2022 Apr;114(4):243-244. doi: 10.17235/reed.2021.8522/2021. PMID: 34991326.
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Citation tools
Ortega Larrodé A, Hurtado de Mendoza L, Mata Casado S, Palomino Donayre O, Blas Jhon L, Farrais Villalba S, et all. Blue rubber bleb nevus syndrome. 9913/2023


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Publication history

Received: 22/08/2023

Accepted: 29/09/2023

Online First: 26/10/2023

Published: 13/11/2023

Article Online First time: 65 days

Article editing time: 83 days


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