Year 2023 / Volume 115 / Number 12
Letter
Large cell neuroendocrine carcinoma at the esophagogastric junction. An extremely rare entity

719-720

DOI: 10.17235/reed.2023.9505/2023

Manuel García-Redondo, José Ruiz Pardo, Pedro Antonio Sánchez Fuentes, Elisabet Vidaña Márquez, Ricardo Belda Lozano, Álvaro Pérez-Rodríguez, Íñigo Gorostiaga, Ángel Reina Duarte,

Abstract
We present the third case described to date of large cell neuroendocrine carcinoma located at the esophagogastric junction (LCNEC). Esophageal neuroendocrine tumours account for 0.03-0.05% of all malignant esophageal tumours. Within oesophageal NETs, LCNEC accounts for 1% of esophageal NETs. This tumour type is characterised by elevated levels of certain markers: synaptophysin, chromogranin A and CD56. In fact, 100% of patients will have chromogranin or synaptophysin, or at least one of these three markers. In turn, 78% will have lymphovascular invasion and 26% will have perineural invasion. Only 11% of patients will have stage I-II, which implies an aggressive course and worse prognosis.
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References
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García-Redondo M, Ruiz Pardo J, Sánchez Fuentes P, Vidaña Márquez E, Belda Lozano R, Pérez-Rodríguez Á, et all. Large cell neuroendocrine carcinoma at the esophagogastric junction. An extremely rare entity. 9505/2023


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Publication history

Received: 31/01/2023

Accepted: 10/02/2023

Online First: 22/02/2023

Published: 12/12/2023

Article Online First time: 22 days

Article editing time: 315 days


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