Year 2025 / Volume 117 / Number 10
Letter
Small bowel ulcers and hypoproteinemia, differential diagnosis beyond inflammatory bowel disease

619-620

DOI: 10.17235/reed.2024.10859/2024

Sandra Borrego Rivas, Alia Martín Izquierdo, Patricia Suárez Álvarez, Irene Latras Cortés, Mónica Sierra Ausín,

Abstract
Protein-losing enteropathy is a relatively uncommon syndrome characterized by excessive loss of proteins into the intestinal lumen. It can be caused by various etiologies. Inflammatory bowel disease (IBD) is the first condition we think of when we meet a patient with intestinal ulcers and hypoproteinemia. However, there are many other complicated and relatively novel etiologies, which we must be aware of in order to perform an appropriate differential diagnosis, such as the one we present.
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References
1. Keuchel, Martin, et al. “Small Bowel Ulcers.” Current Opinion in Gastroenterology, vol. 35, no. 3, May 2019, pp. 213–222.
2. Singh, Ayaskanta. “Cryptogenic Multifocal Ulcerating Stenosing Enteropathy(CMUSE) And/or Chronic Non-Specific Multiple Ulcers of the Small Intestine(CNSU) and Non-Granulomatous Ulcerating Jejunoileitis (NGUJI).” Current Gastroenterology Reports, vol. 21, no. 53, 10 Sept. 2019.
3. McAlindon, Mark E. “Cryptogenic Multifocal Ulcerating Stenosing Enteritis and Other Under-Recognised Small Bowel Inflammatory Enteropathies.” Current Opinion in Gastroenterology, vol. 38, no. 3, 11 Mar. 2022, pp. 279–284.
4. Venegas-Gómez VA, Ruiz-Manríquez J, Falcón-Antonio OE, Zamora-Nava LE. Protein-losing enteropathy secondary to graft-versus-host disease. Rev Esp Enferm Dig. 2024 Apr;116(4):238-239. doi: 10.17235/reed.2023.9902/2023. PMID: 37732351.
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Borrego Rivas S, Martín Izquierdo A, Suárez Álvarez P, Latras Cortés I, Sierra Ausín M. Small bowel ulcers and hypoproteinemia, differential diagnosis beyond inflammatory bowel disease. 10859/2024


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Publication history

Received: 11/10/2024

Accepted: 21/10/2024

Online First: 12/11/2024

Published: 10/10/2025

Article Online First time: 32 days

Article editing time: 364 days


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