Year 2020 / Volume 112 / Number 11
Letter
Severe enterocolitis secondary to ipilimumab and nivolumab with an excellent response to a single dose of infliximab

889-890

DOI: 10.17235/reed.2020.6886/2020

Ana María Luque Carmona, Guillermo Ontanilla-Clavijo, Eduardo Leo Carnerero,

Abstract
Immunotherapy is gaining significance in the management of oncological disease. It has demonstrated high levels of efficacy, though it also has hitherto unknown side effects, such as colitis. We present the first case of immune checkpoint inhibitor colitis (nivolumab+ipilimumab) refractory to corticoids treated in our hospital.
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References
1. Soularue E, Lepage P, Colombel JF et al. Enterocolitis due to immune checkpoint inhibitors: a systematic review. Gut. 2018 Nov;67(11):2056-2067.
2. Abdel-Wahab N, Shah M, Suarez-Almazor ME. Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case Reports. PLoS One. 2016 Jul 29;11(7):e0160221.
3. Yamauchi R, Araki T, Mitsuyama K et al. The characteristics of nivolumab-induced colitis: an evaluation of three cases and a literature review. BMC Gastroenterol. 2018 Aug 31;18(1):135.
4. Marthey L, Mateus C, Mussini C et al. Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease. J Crohns Colitis. 2016 Apr;10(4):395-401.
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Luque Carmona A, Ontanilla-Clavijo G, Leo Carnerero E. Severe enterocolitis secondary to ipilimumab and nivolumab with an excellent response to a single dose of infliximab . 6886/2020


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Publication history

Received: 18/01/2020

Accepted: 31/01/2020

Online First: 15/10/2020

Published: 10/11/2020

Article Online First time: 271 days

Article editing time: 297 days


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