References
1. Costa M, Brookes SJ, Henning GW. Anatomy and physiology of the enteric nervous system. Gut 2000; 47 (Suppl. 4): 15-19.
2. Furness JB. The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol 2012; 9: 289-94.
3. Benarroch EE. Enteric nervous system: functional organization and neurologic implications. Neurology 2007; 69: 1963-7.
4. Blackshaw LA, Brookes SJ, Grundy D, et al. Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil 2007; 19: 1-19.
5. Zhu Y, Meerschaert KA, Galvan-Pena S, et al. A chemogenetic screen for neuroimmune interplay reveals Trpv1+ neuron control of Tregs in gut. Science 2024; 385 (6708):eadk1679. Doi; 10.1126/science.adk1679.
6. Gershon MD, Chalazonitis A, Rothmean TP. From neural crest to bowel: development to the enteric nervous system. J Neurobiol 1993; 24: 199-214.
7. Quigley EMM. Microbiota-brain-gut axis and neurodegenerative diseases. Curr Neurol Neurosci Rep 2017; 17: 94. Doi: 10.1007/s11910-017-0802-6.
8. Agirman G, Yu KB, Hsiao EY. Signaling inflammation across the gut-brain axis. Science 2021; 374: 1087-92. Doi: 10.1126/science.abi6087.
9. Arzani M, Jahromi SR, Ghorbani Z, et al. Gut-brain axis and migraine headache: a comprehensive review. J Headache Pain 2020; 21:15. Doi: 10.1186/s10194-020-1078-10. Hindiyeh N, Aurora SK. What the gut can teach us about migraine. Current Pain Headache Rep 2015; 19: 33. Doi: 10.1007/sl1916-015-0541-4.
11. Aamodt AH, Stovner LJ, Hagen K, et al. Comorbidity of headache and gastrointestinal complaints. The Head-HUNT study. Cephalalgia 2008; 28: 144-51.
12. Cámara-Lemarroy CR, Rodríguez-Gutiérrez R, Monreal-Robles R, et al. Gastrointestinal disorders associated with migraine: a comprehensive review. World J Gastroenterol 2016; 22: 8149-60.
13. Van Hemert S, Breedveld AC, Rovers JMP, et al. Migraine associated with gastrointestinal disorders: review of the literature and clinical implications. Front Neurol 2014; 5: 241. Doi: 10.3389/fneur.2014.00241.
14. He Y, Wang K, Su N, et al. Microbiota-gut-brain axis in health and neurological disease: interactions between gut microbiota and the nervous system. J Cell Mol Med 2024; 28: e70099. Doi: 10.1111/jcmm.70099.
15. He Q, Wang W, Xiong Y, et al. A causal effects of gut microbiota in the development of migraine. J Headache Pain 2023; 24: 90. Doi: 10.1186/s10194-023-01609-x.
16. Mayer EA. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 2013; 12; 453-66.
17. Wei P, Keller C, Li L. Neuropeptides in gut-brain axis and their influence on host immunity and stress. Comput Struct Biotechnol J 2020; 18: 843-51.
18. Holzer P, Farzi A. Neuropeptides and the microbiota-gut-brain axis. Adv Exp Med Biol 2014; 817: 195-219.
19. Amara SG, Jonas V, Rosenfeld MG, et al. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 1982; 298: 240-44.
20. Brain SD, Macintyre AIN, Williams TJ, et al. A second form of human calcitonin gene-related peptide which is a potent vasodilator. Eur J Pharmacol 1986; 124: 349-52.
21. Russell FA, King R, Smillie SJ, et al. Calcitonin gen-related peptide: physiology and pathophysiology. Physiol Rev 2014; 94: 1099-142.
22. Russo AF, Hay DL. CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond. Physiol Rev 2023; 103: 1565-644.
23. Hay DL, Garelja ML, Poyner DR, et al. Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. Br J Pharmacol 2018; 175: 3-17.
24. Eftekhari S, Warfinvinge K, Blixt FW, et al. Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminal system. J Pain 2013; 14: 1289-303.
25. Ramón C, Cernuda-Morollón E, Pascual J. Calcitonin gene-related peptide in peripheral blood as a biomarker for migraine. Curr Opin Neurol 2017; 30: 281-286.
26. Pozo-Rosich P, Coppola G, Pascual J, et al. How does the brain change in chronic migraine? Developing disease biomarkers. Cephalalgia 2021; 41: 613-30.
27. Schütz B, Mauer D, Salmon AM, et al. Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice. J Comp Neurol 2004; 476: 32-43.
28. Mulderry PK, Ghatei MA, Spokes RA, et al. Differential expression of alpha-CGRP and beta-CGRP by primary sensory neurons and enteric autonomic neurons of the rat. Neuroscience 1988; 25: 195-205.
29. Gárate G, Pascual J, Pascual-Mato M, et al. Untangling the mess of CGRP levels as a migraine biomarker: an in-depth literature review and analysis of our experimental experience. J Headache Pain 2024; 25: 69. Doi: 10.1186/s10194-024-01769-4.
30. Xing L, Guo J, Wang X. Induction and expression of beta calcitonin gene-related peptide in rat T lymphocytes and its significance. J Immunol 2000; 165: 4359-66.
31. Manela FD, Ren J, Gao J, et al. Calcitonin gene-related peptide modulates acid-mediated regulation of somatostatin and gastrin release from rat antrum. Gastroenterology 1995; 109: 701-6.
32. Hayashi H, Ohno T, Nishiyama K, Boku K, Katori M, Majima M. Transient prevention of ethanol-induced gastric lesion by capsaicin due to release of endogenous calcitonin gene-related peptide in rats. Jpn J Pharmacol 2001; 86: 351-4.
33. Holzer P, Bartho L, Matusak O, et al. Calcitonin gene-related peptide action on intestinal circular muscle. Am J Physiol Gastrointest Liver Physiol 1989; 256. Doi:10.1152/ajpgi.1989.256.3.G546.
34. Ono T, Nagao M, Imoto H, et al. Effects of calcitonin gene-related peptide on colonic motility and defecation in conscious dogs. J Gastrointest Surg 2018;22: 2097-103.
35. Falkenberg K, Bjerg HR, Olesen J. Two-hour infusion causes gastrointestinal hyperactivity: possible relevance for CGRP antibody treatment. Headache. 2020; 60:929-37.
36. Kaiser EA, Rea BJ, Kuburas A, et al. Anti-CGRP antibodies block CGRP-induced diarrhea in mice. Neuropeptides. 2017; 64: 95-99.
37. Lai NY, Musser MA, Pinho-Ribeiro FA, et al. Gut-innervating nociceptor neurons regulate Peyer’s patch microfold cells and SFB levels to mediate Salmonella host defense. Cell 2020; 180: 33-49.e22.
38. Thompson BJ, Washington MK, Kurre U, et al. Protective roles of alpha calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Dig Dis Sci 2008; 53: 229-41.
39. Engel MA, Khalil M, Siklosi N, et al. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Dig Liver Dis 2012; 44: 24–9.
40. Manning BM, Gruba SM, Meyer AF, et al. Neuropeptide-induced mast cell degranulation and characterization of signaling modulation in response to IgE conditioning. ACS Chem Biol 2016; 11: 3077-83..
41. Balcziak LK, Russo AF. Dural immune cells, CGRP, and migraine. Front Neurol 2022; 13:1-13. doi:10.3389/fneur.2022.862323.
42. Wu W, Feng B, Liu J, et al. The CGRP/macrophage axis signal facilitates inflammation recovery in the intestine. Clin Immunol 2022; 245:109154. Doi: 10.1016/j.clim.2022.109154.
43 Yang D, Jacobson A, Meerschaert KA, et al. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell 202227; 185: 4190-4205.e25.44. Ailani J, Kaiser EA, Mathew PG, et al. Role of calcitonin gene-related peptide on the gastrointestinal symptoms of migraine-clinical considerations. A narrative review. Neurology 2022, 99, 841-53.
45. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 1990; 28: 183-7.
46. Rodríguez-Osorio X, Sobrino T, Brea D, et al. Endothelial progenitor cells: A new key for endothelial dysfunction in migraine. Neurology 2012; 79: 474-479.
47. Cernuda-Morollón E, Larrosa D, Ramón C, et al. Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine. Neurology 2013; 81: 1191-1196.
48. Gárate G, González-Quintanilla V, González A, et al. Serum alpha and beta-CGRP levels in chronic migraine patients before and after monoclocal antibodies against CGRP or its receptor. Ann Neurol 2023; 94: 285-94.
49. Alpuente A, Gallardo VJ, Asskour L, et al. Salivary CGRP and erenumab treatment response: towards precision medicine in migraine. Ann Neurol 2022; 92: 846-59.
50. Van Dogen RM, Zielman R, Noga M, et al. Migraine biomarkers in cerebrospinal fluid: a systematic review and meta-analysis. Cephalalgia 2017; 37: 49-63.
51. Edvinsson L, Haanes KA, Warfvinge K, et al. CGRP as the target of new migraine therapies-successful translation from bench to the clinic. Nat Rev Neurol 2018; 14: 338-50.
52. Caronna E, Alpuente A, Torres-Ferrus M, et al. CGRP monoclonal antibodies and CGRP receptor antagonists (Gepants) in migraine prevention. Handb Clin Neurol 2024; 199: 107-24.
53. Mesina R, Huessler EM, Puledda F, et al. Safety and tolerability of monoclonal antibodies targeting the CGRP pathway and gepants in migraine prevention: A systematic review and network meta-analysis. Cephalalgia 2023, 43, 331024231152169. doi: 10.1177/03331024231152169.
54. Pauza AG, Rysevaite-Kyguoliene K, Mailinauskas M, et al. Alterations in enteric calcitonin gen-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease. Auton Neurosci 2019; 216: 63-71
55. Gárate G, Pascual M, Rivero M, et al. Serum calcitonin gene-related peptide and levels are increased in COVID-19 inpatients. Arch Med Res 2023; 54: 56-63.
56. Gárate G, Toriello M, González-Quintanilla V, et al. Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of trigeminal system. BMC Neurol 2023; 23: 109: Doi: 10.1186/s12883-023-03156-z.
57. Gárate G, Pascual M, Olmos JM, et al. Increase in serum calcitonin-gene related peptide (CGRP) levels in COVID-19 patients with diarrhea: An underlying mechanism? Dig Dis Sci 67: 5712-5713.
58. Pascual-Mato M, Gárate G, de Prado-Tejerina C, et al. Increased prevalence of migraine in women with inflammatory bowel disease: a cross-sectional study. Cephalalgia 2024; 44: 3331024241233979. doi: 10.1177/03331024241233979.
59. Chasman DI, Guo Y, Chan AT, et al. Shared genetics of migraine and gastrointestinal disorders implicates underlying neurologic mechanisms yet heterogeneous etiologies. Neurol Genet 2024; 110: e200201.Doi: 10.1212/NXG.0000000000200201.
60. Pascual-Mato M, Gárate G, González-Quintanilla V, et al. Differences in circulating alpha-calcitonin gene-related peptide levels in inflammatory bowel disease and its relation to migraine comorbidity: a cross-sectional study. Headache 2024; 64: 849-58.
61. Pascual-Mato M, Gárate G, González-Quintanilla V, et al. Unravelling the role of beta-CGRP in inflammatory bowel disease and its potential role in gastrointestinal homeostasis. BMC Gastroenterol 2024; 24:262. Doi: 10.1186/s12876-024-03366-w.
62. Gárate G, Polanco M, Madera J, et al. Influence of constipation in the behavior of circulating alpha and beta-CGRP levels in chronic/high frequency migraine patients after CGRP monoclonal antibodies. Biomedicines, in press.