Year 2023 / Volume 115 / Number 11
Original
The HLA-DQA1*05 genotype does not influence the clinical response to ustekinumab and vedolizumab

608-614

DOI: 10.17235/reed.2023.9491/2023

Pilar Navajas Hernández, Pilar del Pino Bellido, Laura Lorenzo González, Concepción González Rodríguez, Antonio Pérez Pérez, Federico Argüelles Arias,

Abstract
Background: the success of strategies with earlier anti-TNF drugs for the treatment of inflammatory bowel disease (IBD) have been shadowed by the development of anti-drug antibodies that reduce their effectiveness. The HLA-DQA1*05 allele has been shown to increase the risk of immunogenicity to anti-TNF drugs by approximately two-fold. The negative impact of this allele has not been fully investigated for newer biotherapies. Objective: whether the presence of the HLA-DQA1*05 allele is associated with a reduction of response to ustekinumab and vedolizumab was investigated. Material and methods: the impact of HLA-DQA1*05 on disease activity in 93 patients with IBD, treated with ustekinumab (n = 39) or vedolizumab (n = 54) was investigated in a retrospective cohort study. Treatment response and remission was assessed at 6 and 12 months for ustekinumab, and up to 18 and 24 months for vedolizumab, using Harvey-Bradshaw index (Crohn’s disease) and Mayo score (ulcerative colitis). Results: the HLA-DQA1*05 allele was found in 35.9 % and 38.9 % of patients treated with ustekinumab and vedolizumab, respectively. Clinical response was not affected by the presence of the HLA-DQA1*05 allele for both treatment groups. Conclusions: in contrast to anti-TNF drugs, HLA-DQA1*05 presence does not correlate with the decreased response to ustekinumab or vedolizumab.
Lay Summary
Studies suggest that the presence of a genetic allele (HLA-DQA1*05) has been implicated in a worse response and development of antibodies to certain biologic therapies, in particular anti-TNFs (the most commonly used drugs in inflammatory bowel disease). Newer drugs used more recently in IBD include ustekinumab and vedolizumab. There is no evidence that this genotype is associated with response to these drugs, which is why the aim of our study was to evaluate whether the presence of the HLA-DQA1*05 allele is associated with a reduced response to ustekinumab and vedolizumab. To do so, we conducted a retrospective study, in which we concluded that the clinical response to these drugs was not affected by the presence of the HLA-DQA1*05 allele in both treatment groups in contrast to the anti-TNF drugs, HLA-DQA1*05 carriage does not correlate with decreased response to ustekinumab or vedolizumab.
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Citation tools
Navajas Hernández P, del Pino Bellido P, Lorenzo González L, González Rodríguez C, Pérez Pérez A, Argüelles Arias F, et all. The HLA-DQA1*05 genotype does not influence the clinical response to ustekinumab and vedolizumab. 9491/2023


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Publication history

Received: 25/01/2023

Accepted: 17/05/2023

Online First: 14/06/2023

Published: 13/11/2023

Article revision time: 99 days

Article Online First time: 140 days

Article editing time: 292 days


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