Year 2017 / Volume 109 / Number 11
Original
Recurrence of infection and diversity of Helicobacter pylori strains in an adult population in Mexico treated with empirical standard triple therapy

749-756

DOI: 10.17235/reed.2017.4994/2017

Jaime Alberto Sánchez Cuén, Ana Bertha Irineo Cabrales, Nidia Maribel León Sicairos, Loranda Calderón Zamora, Luis Monroy Higuera, Vicente Adrián Canizalez Román,

Abstract
Background. After eradication treatment for Helicobacter pylori, infection could recur due to recrudescence or re-infection. The objective of this study was to determine the recurrence of Helicobacter pylori infection and identify virulent Helicobacter pylori strains one year after eradication with standard triple therapy. Material and methods. A quasi-experimental study was performed that included a patient population with digestive diseases associated with Helicobacter pylori who had received standard triple therapy. Cultures and Polymerase Chain Reaction was performed on gastric biopsies for strain identification in all patients prior to eradication treatment and those with a positive carbon 14 breath test one year after eradication treatment. Statistical analysis was performed using the student T test and Fisher’s exact test, statistical significance was set at 0.05. Results. 128 patients were studied, 51 (39.8%) were male and 77 (60.2%) were female with an average age of 54.8 years (DE 13.8). There was an annual recurrence of Helicobacter pylori infection in 12 (9.3%) patients. An annual re-infection and recrudescence occurred in 9 (7 %) and 3 (2.3%) patients respectively. The recrudescence rate for cagA was 1/30 (3.3%) patients and 2/112 (1.8%) patients for vacA. The re-infection rate for cagA was 3/30 (10%) patients and 6/112 (5.3%) patients for vacA. Conclusions. The recurrence of infection in this study was higher than that recorded in developed countries with a low prevalence of H. pylori and lower than that recorded in developing countries with a higher prevalence of H. pylori. The cagA or vacA s2/m2 strains were isolated after re-infection and recrudescence.
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Sánchez Cuén J, Irineo Cabrales A, León Sicairos N, Calderón Zamora L, Monroy Higuera L, Canizalez Román V, et all. Recurrence of infection and diversity of Helicobacter pylori strains in an adult population in Mexico treated with empirical standard triple therapy . 4994/2017


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Publication history

Received: 06/04/2017

Accepted: 17/06/2017

Online First: 26/10/2017

Published: 02/11/2017

Article revision time: 66 days

Article Online First time: 203 days

Article editing time: 210 days


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