Year 2020 / Volume 112 / Number 12
Original
Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

925-928

DOI: 10.17235/reed.2020.7150/2020

João Carlos Silva, Ana Ponte, Margarida Mota, Rolando Pinho, Nuno Vieira, Rosa Oliveira, Nelson Mota-Carvalho, Ana Catarina Gomes, Edgar Afecto, João Carvalho,

Abstract
Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
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Silva J, Ponte A, Mota M, Pinho R, Vieira N, Oliveira R, et all. Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae. 7150/2020


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Publication history

Received: 16/04/2020

Accepted: 25/06/2020

Online First: 29/10/2020

Published: 09/12/2020

Article revision time: 63 days

Article Online First time: 196 days

Article editing time: 237 days


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