Year 2025 / Volume 117 / Number 8
Letter
Primary gastric rhabdomyosarcoma. A rare cause of an upper gastrointestinal bleeding

476-477

DOI: 10.17235/reed.2024.10538/2024

Eduany Hernández, Javier Tejedor-Tejada, Laura Sánchez Sanmamed, Cristina Camblor, Ana Villar Caamaño, Samuel Robles Gaitero, Esmeralda Groba,

Abstract
Adenocarcinoma accounts for 90% of malignant gastric tumours. Lymphomas, gastrointestinal stromal tumours (GIST) and other less frequent tumours account for 10%. However, rhabdomyosarcoma (RMS) remains a rare cause within the broad differential diagnosis of gastric lesions. Most cases of gastrointestinal RMS in adults are metastatic disease so primary RMS is extremely rare. A few cases reports of esophageal and gastric RMS have been published. This is a 76-year-old patient with a history of oncological oncology of poorly differentiated lung adenocarcinoma T2N1M0 in 2008 treated with surgery with no signs of recurrence. She presented to emergency with occasional episodes of melena and iron deficiency anemia for the last 3 months. The laboratory findings showed moderated anemia. Gastroscopy was performed and a prominent submucosal and ulcerated bulge was observed at the posterior wall of the gastric body and fundus. A histologic examination reveled tissue fragments composed of small round spindle-shaped cells. Tumor cells had atypical nuclei showing dense chromatin ad pale to eosinophilic cytoplasm. Immunohistochemically, the tumor was positive for AE1/3, desmin, myogenin and CD56. Patient was diagnosed with primary gastric RMS. Thoraco-abdominopelvic CT showed a locally advanced stage (T2 N1M0).
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References
1. Nakamura N, Suzuki R, Takahashi Y, et al. Primary Gastric Rhabdomyosarcoma. Intern Med. 2023 Dec 1;62(23):3483-3488. doi: 10.2169/internalmedicine.1645-23. Epub 2023 Apr 21. PMID: 37081684; PMCID: PMC10749818.
2. Shah LK, Mony NJ, Mishra S, et al. An Exceptionally Rare Primary Epithelioid Rhabdomyosarcomas of the Stomach: A Case Report. Cureus. 2022 Jun 17;14(6):e26046. doi: 10.7759/cureus.26046. PMID: 35859978; PMCID: PMC9288843.
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Citation tools
Hernández E, Tejedor-Tejada J, Sánchez Sanmamed L, Camblor C, Villar Caamaño A, Robles Gaitero S, et all. Primary gastric rhabdomyosarcoma. A rare cause of an upper gastrointestinal bleeding. 10538/2024


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Publication history

Received: 14/05/2024

Accepted: 27/05/2024

Online First: 04/06/2024

Published: 24/07/2025

Article Online First time: 21 days

Article editing time: 436 days


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