Año 2016 / Volumen 108 / Número 10
Caso Clínico
Glycogenic hepatopathy in young adults: a case series

673-676

DOI: 10.17235/reed.2016.3934/2015

Marco Silva, Margarida Marques, Hélder Cardoso, Susana Rodrigues, Patrícia Andrade, Armando Peixoto, Joana Pardal, Joanne Lopes, Fátima Carneiro, Guilherme Macedo,

Resumen
Glycogenic hepatopathy is a rare and under-recognized complication in long-standing poorly controlled type 1 diabetes mellitus patients. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics, such as nonalcoholic fatty liver disease. Glycogenic hepatopathy is characterized by the combination of poorly controlled diabetes, acute liver injury with marked elevation in serum aminotransferases, and the characteristic histological features on liver biopsy. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control. In this report, we describe four cases of adult patients presenting elevated serum transaminases and hepatomegaly with a history of poorly controlled type I diabetes mellitus. One of the patients had also elevated amylase and lipase in the serum, without clinical or imagiologic evidence of acute pancreatitis (AP). Liver biopsy was performed in all patients and revealed glycogenic hepatopathy. Clinician’s awareness of glycogenic hepatopathy should prevent diagnostic delay or misdiagnosis and will provide better insight and management for this condition.
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Bibliografía
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Silva M, Marques M, Cardoso H, Rodrigues S, Andrade P, Peixoto A, et all. Glycogenic hepatopathy in young adults: a case series. 3934/2015


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Ficha Técnica

Recibido: 19/07/2015

Aceptado: 16/09/2015

Prepublicado: 22/02/2016

Publicado: 30/09/2016

Tiempo de revisión del artículo: 58 días

Tiempo de prepublicación: 218 días

Tiempo de edición del artículo: 439 días


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