Year 2022 / Volume 114 / Number 6
Original
Participation in clinical trials increases the detection of pre-malignant lesions during colonoscopy

323-328

DOI: 10.17235/reed.2021.8104/2021

Alexandre Oliveira Ferreira, Maria Pia Costa-Santos, Catarina Gomes, Bárbara Morão, Luisa Glória, Marília Cravo, Mário Dinis-Ribeiro, Jorge Canena,

Abstract
Background: colorectal adenoma detection has been associated with the effectiveness of cancer prevention. Clinical trials have been designed to determine the role of several interventions to increase the detection of pre-malignant lesions. We hypothesized that colonoscopy in the setting of clinical trials has a higher pre-malignant lesion detection rate. Methods: a cross-sectional study was performed that compared the detection of pre-malignant lesions in 147 randomly sampled non-research colonoscopies and 294 from the control group of two prospective trials. Outpatients aged 40-79 years, with no personal history of colorectal cancer (CRC) were included. Results: baseline characteristics were similar between the two groups. The pre-malignant lesion detection rate in the trial vs control group was 65.6 % vs 44.2 % (OR 2.411; 95 % CI: 1.608-3.614; p < 0.001), the polyp detection rate was 73.8 % vs 59.9 % (OR 1.889; 95 % CI: 1.242-2.876; p = 0.003), the adenoma detection rate was 62.6 % vs 44.2 % (OR 2.110; 95 % CI: 1.411-3.155; p < 0.001) and the sessile serrated lesion detection rate was 17 % vs 4.1 % (OR 4.816; 95 % CI: 2.014-11.515; p < 0.001). The mean number of pre-malignant and sessile serrated lesions was 1.70 vs 1.06 (p = 0.002) and 0.32 vs 0.06 (p = 0.001) lesions per colonoscopy, respectively. There was no significant change in any of the study outcomes according to the multivariate analysis with each single potential confounder. Conclusions: patients involved in colonoscopy trials may benefit from higher quality examinations, as shown by the higher detection rates. Institutions should consider supporting clinical research in colonoscopy as a simple means to improve colonoscopy quality and colorectal cancer prevention.
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Ferreira A, Costa-Santos M, Gomes C, Morão B, Glória L, Cravo M, et all. Participation in clinical trials increases the detection of pre-malignant lesions during colonoscopy. 8104/2021


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Publication history

Received: 15/05/2021

Accepted: 26/09/2021

Online First: 05/10/2021

Published: 07/06/2022

Article revision time: 104 days

Article Online First time: 143 days

Article editing time: 388 days


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