Year 2016 / Volume 108 / Number 3
Review
Practical considerations in the management of proton-pump inhibitors

145-153

DOI: 10.17235/reed.2015.3812/2015

Lara Aguilera Castro, Carlos Martín de Argila de Prados, Agustín Albillos Martínez,

Abstract
Proton-pump inhibitors (PPIs) are one of the most active ingredients prescribed in Spain. In recent decades there has been an overuse of these drugs in both outpatient clinics and hospitals that has lead to a significant increase in healthcare spending and to an increase in the risk of possible side effects. It is important for health professionals to know the accepted indications and the correct doses for the use of these drugs. On the market there are different types of PPI: omeprazole, pantoprazole, lansoprazole, rabeprazole and esomeprazole. Omeprazole is the oldest and most used PPI, being also the cheapest. Although there are no important differences between PPIs in curing diseases, esomeprazole, a new-generation PPI, has proved to be more effective in eradicating H. pylori and in healing severe esophagitis compared to other PPIs. In recent years the use of generic drugs has spread; these drugs have the same bioavailability than the original drugs. In the case of PPIs, the few comparative studies available in the literature between original and generic drugs have shown no significant differences in clinical efficacy.
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Publication history

Received: 16/04/2015

Accepted: 12/06/2015

Online First: 15/12/2015

Published: 26/02/2016

Article revision time: 55 days

Article Online First time: 243 days

Article editing time: 316 days


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