Year 2025 / Volume 117 / Number 12
Letter
Is it necessary to repeat the interferon gamma? Disseminated tuberculosis in a patient receiving anti-TNF alpha treatment

778-779

DOI: 10.17235/reed.2024.10716/2024

Cristina Martínez-Cuevas, Esteban Andrés Fuentes Valenzuela, Paula Bayo Juanas, Alicia Sanjosé Crespo, Jorge Lillo Díez, José Pablo Miramontes-González,

Abstract
Before starting a drug that suppresses immunity, it is of paramount importance to screen for hidden infections in patients with inflammatory diseases. Latent tuberculosis infection (LTBI) is a condition characterized by an immune response to M. tuberculosis antigens without clinical manifestations. The highest risk of progression to active disease occurs in individuals who are immunosuppressed or in children. Patients who are candidates for treatment with TNF-alpha inhibitors should be evaluated with interferon gamma release assays and a chest radiograph. We present a case of a 42 year old woman with a history of Crohn disease treated with infliximab and fever with adenopatys.
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References
1. Fortún Enrique Navas J. Latent tuberculosis infection: approach and therapeutic schemes. Rev Esp Quimioter. 2022;35:94–6.
2. Opportunistic M, Related I, Biological S, Be T, Or S. En Enfermedad Inflamatoria Intestinal : ¿ Suspender O Continuar La Terapia Biológica ? Multiple Opportunistic Infections Related To Infliximab in Inflammatory Bowel Disease : Should Biological Therapy Be Stopped or. 2017;40:97–101.
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4. da Silva DIC, Santos BH de O, Renosto FL, Watanabe EM, Herrerias GSP, Saad-Hossne R, et al. Pulmonary tuberculosis after therapy with anti-tumor necrosis factor (Tnf) for crohn disease: A case report. Am J Case Rep. 2021;22(1):1–9.
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Citation tools
Martínez-Cuevas C, Fuentes Valenzuela E, Bayo Juanas P, Sanjosé Crespo A, Lillo Díez J, Miramontes-González J, et all. Is it necessary to repeat the interferon gamma? Disseminated tuberculosis in a patient receiving anti-TNF alpha treatment. 10716/2024


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Publication history

Received: 07/08/2024

Accepted: 18/09/2024

Online First: 26/09/2024

Published: 12/12/2025

Article Online First time: 50 days

Article editing time: 492 days


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