Year 2025 / Volume 117 / Number 12
Letter
Endoscopic submucosal dissection of early gastric adenocarcinoma of fundic gland type

807-808

DOI: 10.17235/reed.2025.11551/2025

Ming Zhong, Wei Wei, Huang Zhong, Hang Gong, Tingyu Wang,

Abstract
A 57-year-old woman presented to our department, complaining of abdominal pain for 1 week. Esophagogastroduodenoscopy (EGD) revealed a 0.3 × 0.4 cm, slightly elevated lesion located on the greater curvature of the upper gastric body, classified as type 0-IIa (superficial elevated). Narrow-band imaging (NBI) demonstrated brownish discoloration of the lesion's surface with a branching vascular pattern of dilated capillaries. Histopathological examination of the EGD biopsy revealed a gastric adenocarcinoma of fundic gland type. The observed cancerous lesion was treated via endoscopic submucosal dissection (ESD). Post-ESD histopathology confirmed a gastric adenocarcinoma of fundic gland type (histologic grade E). The tumor measured 2.8 mm in maximum diameter and focally invaded the submucosa, with the deepest invasive front extending 0.4 mm below the muscularis mucosae. Both lateral and vertical resection margins were free of carcinoma.
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References
1.Park ES, Kim YE, Park CK, et al. Gastric adenocarcinoma of fundic gland type: report of three cases. Korean J Pathol. 2012;46(3):287-291. doi:10.4132/KoreanJPathol.2012.46.3.287.
2.Imamura K, Yao K, Nimura S, et al. Characteristic endoscopic findings of gastric adenocarcinoma of fundic-gland mucosa type. Gastric Cancer. 2021;24(6):1307-1319. doi:10.1007/s10120-021-01208-2.
3.Zhang H, Wang S, Zhang Y, Ye F, Wang C. Clinicopathological features of early stage gastric adenocarcinoma of fundic gland type: Case series. Medicine (Baltimore). 2022;101(2):e28469. doi:10.1097/MD.0000000000028469.
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Zhong M, Wei W, Zhong H, Gong H, Wang T. Endoscopic submucosal dissection of early gastric adenocarcinoma of fundic gland type. 11551/2025


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Publication history

Received: 05/08/2025

Accepted: 09/08/2025

Online First: 29/09/2025

Published: 12/12/2025

Article Online First time: 55 days

Article editing time: 129 days


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