Year 2026 / Volume 118 / Number 3
Letter
Interdigitating dendritic cell sarcoma presenting as retroperitoneal mass and obstructive jaundice. An uncommon entity of complex diagnosis

177-178

DOI: 10.17235/reed.2024.10947/2024

Alejandro Nieto-Jara, Marta García Calonge, Fernando Fernández Cadenas, Óscar González Bernardo,

Abstract
A 60-year-old male was admitted for obstructive jaundice secondary to a 2 cm retroperitoneal lesion. Ultrasound endoscopy (UES) with fine needle biopsy (FNB) was performed, as well as endoscopic retrograde cholangiopancreatography (ERCP) with placement of a metal stent for bile duct drainage. Initially IgG4-related disease was suspected from FNB. After 8 months of treatment the patient attended with a progression evidenced in computed tomography (CT) with retroperitoneal adenopathies and liver metastasis, with involvement of duodenum and fistulation towards hepatic angle of colon. Upper endoscopy and colonoscopy was performed. The patient underwent a cephalic duodenopancreatectomy with antrectomy and right hemicolectomy. The histological study of the specimen revealed cells of fascicular distribution, fusiform aspect, with ovoid nuclei, accompanied by a polymorphic inflammatory infiltrate with mononuclear cells. Immunohistochemistry (IHQ) was positive for S100, CD21, CD23, D2-40 and Bcl-2 and negative for CD1a, CD2, CD3, CD4, CD5, CD8, CD20, CD79a, PD1, desmine, langherin, c-kit, PDGFR. These findings were suggestive of interdigitating dendritic cell sarcoma (IDCS). Systemic chemotherapy with R-CHOP was initiated and after the first 4 cycles of treatment, retroperitoneal adenopathies regressed, with stability of metastatic liver disease.
New comment
Comments
No comments for this article
References
1. Pokuri VK, Merzianu M. Interdigitating dendritic cell sarcoma. J Natl Compr Canc Netw. 2015 Feb;13(2):128-32.
2. Saygin C, Uzunaslan D. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol. 2013 Nov;88(2):253-71.
3. Muhammed A, Ahmed ARH. New insights inside the interdigitating dendritic cell sarcoma-pooled analysis and review of literature. Ann Hematol. 2019 Dec;98(12):2641-2651.
4. Barwell N, Howatson R. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol. 2004 Jan;57(1):87-9.
5. Ninkovic S, Cole-Sinclair MF. Interdigitating dendritic cell sarcoma: diagnostic pitfalls, treatment challenges and role of transdifferentation in pathogenesis. Pathology. 2017 Oct;49(6):643-646.
Related articles

Letter

Colon ulcers and HIV: an image to remember

DOI: 10.17235/reed.2025.11078/2025

Letter

Obstructive jaundice of an unusual cause

DOI: 10.17235/reed.2024.10932/2024

Letter

Spontaneous esophageal submucosal hematoma

DOI: 10.17235/reed.2024.10775/2024

Letter

A rare submucosal eminence of the colon

DOI: 10.17235/reed.2024.10707/2024

Letter

An unusual colon mass

DOI: 10.17235/reed.2024.10613/2024

Letter

Capsule endoscopy: beyond the small bowel

DOI: 10.17235/reed.2024.10449/2024

Letter

Diffuse colonic capillary hemangioma mimicking ulcerative colitis

DOI: 10.17235/reed.2024.10298/2024

Letter

Extraosseous Ewing’s sarcoma of the pancreas

DOI: 10.17235/reed.2024.10281/2024

Letter

Histiocytic sarcoma of the spleen without thrombocytopenia

DOI: 10.17235/reed.2024.10249/2024

Letter

Hemorrhagic shock due to ileal varices, a diagnostic challenge

DOI: 10.17235/reed.2024.10241/2024

Digestive Diseases Image

Crohn’s disease: beyond the intestine

DOI: 10.17235/reed.2024.10185/2023

Letter

Epithelioid angiosarcoma of the stomach

DOI: 10.17235/reed.2023.10061/2023

Letter

Esophagitis dissecans superficialis: a rare endoscopic finding

DOI: 10.17235/reed.2023.10058/2023

Letter

Blue rubber bleb nevus syndrome

DOI: 10.17235/reed.2023.9913/2023

Digestive Diseases Image

Jejunum cavernous hemangioma: a rare cause of gastrointestinal bleeding

DOI: 10.17235/reed.2023.9812/2023

Letter

Capsule endoscopy diagnosis of gastrointestinal melanoma

DOI: 10.17235/reed.2023.9803/2023

Letter

Calcifying fibrous tumor and pathological analysis

DOI: 10.17235/reed.2023.9739/2023

Letter

Acute pancreatitis due to osteosarcoma metastasis

DOI: 10.17235/reed.2023.9729/2023

Digestive Diseases Image

Endoscopic manifestations of jejunal choriocarcinoma

DOI: 10.17235/reed.2023.9714/2023

Digestive Diseases Image

Radiotherapy-induced fibrosarcoma of the esophagus

DOI: 10.17235/reed.2023.9708/2023

Letter

Endoscopic observation of a rare duodenal tumor

DOI: 10.17235/reed.2023.9679/2023

Letter

Endoscopic rescue of a fistulizing biliary plastic stent

DOI: 10.17235/reed.2023.9673/2023

Review

POEM from A to Z: current perspectives

DOI: 10.17235/reed.2023.9602/2023

Letter

MALT lymphoma of the colon: an endoscopic challenge

DOI: 10.17235/reed.2023.9595/2023

Letter

The role of gastrointestinal endoscopy in Kaposi sarcoma

DOI: 10.17235/reed.2023.9534/2023

Letter

Sigmoid volvulus management, only endoscopic devolvulation?

DOI: 10.17235/reed.2023.9488/2023

Letter

Isolated Jejunal Crohn's Disease: a challenging diagnosis

DOI: 10.17235/reed.2022.9423/2022

Letter

New technique for the endoscopic removal of long foreign bodies

DOI: 10.17235/reed.2023.9398/2022

Digestive Diseases Image

Whipple’s disease – A typical endoscopic finding of a rare disease

DOI: 10.17235/reed.2022.9338/2022

Letter

Histiocytic sarcoma of the esophagus

DOI: 10.17235/reed.2022.9296/2022

Digestive Diseases Image

A case of esophageal histoplasmosis mimicking carcinoma on endoscopy

DOI: 10.17235/reed.2023.9167/2022

Letter

Primary gastric leiomyosarcoma presenting as a giant polyp

DOI: 10.17235/reed.2022.9165/2022

Digestive Diseases Image

A rare endoscopic pattern in a patient with gastroesophageal reflux disease

DOI: 10.17235/reed.2022.9124/2022

Digestive Diseases Image

Esophageal tuberculosis

DOI: 10.17235/reed.2022.9108/2022

Digestive Diseases Image

The sentinel polyp: high-grade sarcoma revealed after colonic polypectomy

DOI: 10.17235/reed.2022.9093/2022

Digestive Diseases Image

Esophagopleural fistula due to empyema necessitans

DOI: 10.17235/reed.2022.9085/2022

Digestive Diseases Image

Pneumatosis intestinalis: a rare endoscopic feature of colonic ischemia

DOI: 10.17235/reed.2022.8980/2022

Letter

Primary intestinal melanoma?

DOI: 10.17235/reed.2022.8944/2022

Letter

Intestinal amyloidosis: a diagnostic challenge

DOI: 10.17235/reed.2022.8934/2022

Letter

Successful gallstone ileus treatment by endoscopy

DOI: 10.17235/reed.2022.8898/2022

Letter

Intra-abdominal epithelioid angiosarcoma

DOI: 10.17235/reed.2022.8878/2022

Letter

Angiosarcoma of the aorta diagnosed via endoscopic ultrasound

DOI: 10.17235/reed.2022.8879/2022

Letter

Digestive tract MALT lymphoma, an unusual location

DOI: 10.17235/reed.2022.8800/2022

Digestive Diseases Image

Colonic Kaposi’s sarcoma as the first clinical manifestation of undiagnosed HIV

DOI: 10.17235/reed.2022.8717/2022

Digestive Diseases Image

Esophageal epidermoid metaplasia: an unusual condition

DOI: 10.17235/reed.2022.8708/2022

Digestive Diseases Image

Ileal neuroendocrine tumor as an uncommon cause of obscure gastrointestinal bleeding

DOI: 10.17235/reed.2022.8641/2022

Digestive Diseases Image

Kaposi’s sarcoma with atypical gastrointestinal involvement

DOI: 10.17235/reed.2021.8275/2021

Digestive Diseases Image

A case of duodenal-type follicular lymphoma

DOI: 10.17235/reed.2021.8233/2021

Digestive Diseases Image

Endoscopic resection of a duodenal neuroendocrine tumor

DOI: 10.17235/reed.2021.8232/2021

Digestive Diseases Image

Duodenal-type follicular lymphoma: a silent tumor

DOI: 10.17235/reed.2021.8149/2021

Digestive Diseases Image

“White bile” as a result of a malignant bile obstruction

DOI: 10.17235/reed.2021.8098/2021

Digestive Diseases Image

Primary or idiopathic intestinal pneumatosis: a rare casual endoscopic finding

DOI: 10.17235/reed.2021.8049/2021

Letter

Bochdalek hernia: use of capsule endoscopy

DOI: 10.17235/reed.2021.7760/2020

Letter

Primary Ewing's sarcoma of the small intestine

DOI: 10.17235/reed.2021.7735/2020

Digestive Diseases Image

Endoscopic forceps removal for complicated magnetic beads impaction

DOI: 10.17235/reed.2021.7731/2020

Digestive Diseases Image

Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the liver

DOI: 10.17235/reed.2020.7602/2020

Digestive Diseases Image

Esophageal involvement in a patient with pemphigus vulgaris

DOI: 10.17235/reed.2020.7417/2020

Letter

Basic training in gastrointestinal endoscopy: recording images

DOI: 10.17235/reed.2020.7385/2020

Review

Advanced therapy by device-assisted enteroscopy

DOI: 10.17235/reed.2020.6971/2020

Letter

Luetic gastritis: an uncommon cause of gastritis

DOI: 10.17235/reed.2020.6870/2020

Letter

Gastric ulcer due to mucormycosis in a critical patient

DOI: 10.17235/reed.2020.6636/2019

Letter

Primary gastric choriocarcinoma

DOI: 10.17235/reed.2020.6478/2019

Digestive Diseases Image

Jejunal schwannoma detected by video capsule endoscopy

DOI: 10.17235/reed.2020.6474/2019

Digestive Diseases Image

Capsule endoscopy, a useful tool for the diagnosis of a tapeworm infection

DOI: 10.17235/reed.2019.6346/2019

Editorial

Endoscopy units – Statu quo

DOI: 10.17235/reed.2019.6347/2019

Letter

Endoscopically diagnosed systemic mastocytosis

DOI: 10.17235/reed.2019.6246/2019

Letter

Ruptured hepatic sarcoma as a cause of acute abdomen

DOI: 10.17235/reed.2019.6163/2019

Digestive Diseases Image

A rare heterotopic gastric mucosa appearing between the muscularis mucosae and submucosa

DOI: 10.17235/reed.2019.6134/2018

Special Article

Quality indicators in gastroscopy. Gastroscopy procedure

DOI: 10.17235/reed.2019.6023/2018

Letter

Endoscopic management of Boerhaave’s syndrome

DOI: 10.17235/reed.2019.6013/2018

Digestive Diseases Image

Intraductal papillary mucinous neoplasm of the main duct in a patient with pancreas divisum

DOI: 10.17235/reed.2019.5959/2018

Letter

Use of patency capsule in daily practice

DOI: 10.17235/reed.2019.5952/2018

Letter

Carcinosarcoma of the ampulla of Vater

DOI: 10.17235/reed.2019.5932/2018

Digestive Diseases Image

Mirizzi syndrome: when the gallbladder meets bile ducts

DOI: 10.17235/reed.2019.5846/2018

Letter

Obstructive jaundice of a parasitic etiology

DOI: 10.17235/reed.2018.5827/2018

Letter

Symptomatic exfoliative esophagitis induced by dabigatran

DOI: 10.17235/reed.2018.5747/2018

Special Article

The current situation of digestive endoscopy units in the Valencian Community

DOI: 10.17235/reed.2019.5676/2018

Digestive Diseases Image

Painless jaundice as an initial presentation of lung adenocarcinoma

DOI: 10.17235/reed.2018.5587/2018

Special Article

Endoscopy and sedation: an inseparable binomial for the gastroenterologist

DOI: 10.17235/reed.2018.5585/2018

Letter

Obstructive jaundice secondary to a hepatic hydatid cyst

DOI: 10.17235/reed.2018.5574/2018

Digestive Diseases Image

Dysphagia and hematemesis caused by an intramural esophageal dissection

DOI: 10.17235/reed.2018.5471/2018

Letter to the Editor

Complicated peribiliary cysts in patient without any prior liver disease

DOI: 10.17235/reed.2017.5350/2017

Digestive Diseases Image

Giant intra-abdominal liposarcoma

DOI: 10.17235/reed.2018.5176/2017

Letter to the Editor

GETTEMO position statement on bariatric endoscopic techniques as a voluntary medicine

DOI: 10.17235/reed.2017.5144/2017

Digestive Diseases Image

Metastasis of dermatofibrosarcoma diagnosed by capsule endoscopy

DOI: 10.17235/reed.2018.4900/2017

Letter to the Editor

Symptomatic retention of the Agile® patency capsule

DOI: 10.17235/reed.2017.4691/2016

Letter to the Editor

Ball valve syndrome caused by a giant gastric Vanek’s tumor

DOI: 10.17235/reed.2017.4526/2016

Original

Multicenter study on the safety of bariatric endoscopy

DOI: 10.17235/reed.2017.4499/2016

Letter to the Editor

Endoscopic removal of a hashish packet

DOI: 10.17235/reed.2017.4504/2016

Letter to the Editor

Whipple’s disease under the vision of capsule endoscopy

DOI: 10.17235/reed.2016.4362/2016

Letter to the Editor

Asymptomatic bronchial aspiration of capsule endoscope: a significant complication

DOI: 10.17235/reed.2016.4363/2016

Letter to the Editor

Author´s reply: About human taeniasis and Taenia saginata diagnosis by endoscopy

DOI: 10.17235/reed.2016.4339/2016

Letter to the Editor

About human taeniasis and Taenia saginata diagnosis by endoscopy

DOI: 10.17235/reed.2016.4297/2016

Letter to the Editor

Transanal submucosal endoscopic resection (TASER) by TEO system®

DOI: 10.17235/reed.2016.4154/2015

Case Report

Atypical diagnosis diagnosis by endoscopic capsule: Whipple´s disease

DOI: 10.17235/reed.2015.3718/2015

Letter to the Editor

Leiomyosarcoma of the ascending colon: a rare tumor with poor prognosis

DOI: 10.17235/reed.2015.3606/2014

Citation tools
Nieto-Jara A, García Calonge M, Fernández Cadenas F, González Bernardo Ó. Interdigitating dendritic cell sarcoma presenting as retroperitoneal mass and obstructive jaundice. An uncommon entity of complex diagnosis. 10947/2024


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 4 visits.
This article has been downloaded 0 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 16/11/2024

Accepted: 25/11/2024

Online First: 04/12/2024

Published: 06/03/2026

Article Online First time: 18 days

Article editing time: 475 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2026 y Creative Commons. The Spanish Journal of Gastroenterology