Year 2023 / Volume 115 / Number 12
Letter
Primary esophageal follicular lymphoma: a rare entity

737-738

DOI: 10.17235/reed.2023.9651/2023

Cláudio Rodrigues, Diana Martins, Nuno Dias, Américo Silva,

Abstract
A 63-year-old woman presented with dyspepsia de novo. An esophagogastroduodenoscopy revealed a 30 mm flat yellowish esophageal lesion, 28 cm from the incisors (Fig. 1a), with the stomach and duodenum without any lesion. Helicobacter pylori infection was excluded. Histological examination was suggestive of a lymphoproliferative process (Fig. 1b). Immunohistochemistry showed diffuse positivity for CD20 (Fig. 1c) and BCL-2 (Fig. 1d), dim CD10 and BCL-6 staining, a Ki-67 of 20-25%, no CD21 or cyclin D1 expression, all these features compatible with low-grade follicular lymphoma. Physical examination was unremarkable. Computed tomography of the neck, chest, and abdomen revealed no lymph node enlargement, hepatosplenomegaly or metastasis. Blood routine tests and tumor markers were at normal levels. Bone marrow biopsy showed no involvement by lymphoma. Therefore, a diagnosis of primary follicular lymphoma of the esophagus was made. The patient opted for a watch-and-wait strategy and there is no evidence of disease progression after four years of follow-up.
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References
1. Ghimire P, Wu GY, Zhu L. Primary esophageal lymphoma in immunocompetent patients: Two case reports and literature review. World J Radiol. 2010 Aug 28;2(8):334-8.
2. Howell JM, Auer-Grzesiak I, Zhang J, et al. Increasing incidence rates, distribution and histological characteristics of primary gastrointestinal non-Hodgkin lymphoma in a North American population. Can J Gastroenterol 2012;26:452-456.
3. Álvarez Martínez P, Ramos Martínez PJ, García González P, et al. Primary esophageal diffuse large B-cell lymphoma. Rev Esp Enferm Dig. 2022 Nov 10.
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Rodrigues C, Martins D, Dias N, Silva A. Primary esophageal follicular lymphoma: a rare entity. 9651/2023


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Publication history

Received: 10/04/2023

Accepted: 14/04/2023

Online First: 28/04/2023

Published: 12/12/2023

Article Online First time: 18 days

Article editing time: 246 days


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