Year 2021 / Volume 113 / Number 3
Original
Ustekinumab treatment for toxic megacolon in severe colonic Crohn’s disease

189-192

DOI: 10.17235/reed.2020.7228/2020

Martín Irabien, Paz Arreba, Jone Ortiz de Zárate, Nerea Hernández-Aretxabaleta, Saioa de la Maza-Ortiz, Nahia Ispizua-Madariaga, Carmen Muñoz-Villafranca,

Abstract
Toxic megacolon is most commonly considered as a complication of inflammatory bowel disease, especially ulcerative colitis and colonic Crohn’s disease to a lesser extent. It appears in the context of moderate-to-severe disease and often requires colectomy. Currently, after an inadequate response to conventional therapy with systemic corticosteroids, the use of cyclosporine or infliximab is considered as an alternative option, prior to surgical intervention. We present a case report of toxic megacolon in a patient with a severe refractory colonic Crohn’s disease, where anti-tumor necrosis factor (anti-TNF) therapies were contraindicated. Consequently, we decided to use ustekinumab as a rescue therapy, despite insufficient evidence to provide recommendations for this indication.
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References
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Irabien M, Arreba P, Ortiz de Zárate J, Hernández-Aretxabaleta N, de la Maza-Ortiz S, Ispizua-Madariaga N, et all. Ustekinumab treatment for toxic megacolon in severe colonic Crohn’s disease. 7228/2020


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Publication history

Received: 05/05/2020

Accepted: 06/08/2020

Online First: 27/11/2020

Published: 08/03/2021

Article revision time: 89 days

Article Online First time: 206 days

Article editing time: 307 days


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