Year 2024 / Volume 116 / Number 1
Letter
Mixed adenoneuroendocrine carcinoma of the gallbladder

48-49

DOI: 10.17235/reed.2023.9624/2023

Qi Wang, Lixia Li, Jun Li, Wanfeng Fan,

Abstract
A 58-year-old woman presented with a 1-day history of abdominal pain. Abdominal CT showed an oval soft tissue density mass in the fundus of the gallbladder (red arrow), approximately 4.0 cm × 3.0 cm in size. The level of cancer antigen 199 was elevated (275.80 U/mL; normal level, 0.0-27.0 U/mL). Other tumor markers were normal including alpha fetoprotein, carcinoembryonic antigen. Abdominal magnetic resonance imaging demonstrated the mass with characteristic of mixed signals, containing marked enhanced ingredient (yellow arrow) and poor blood supply ingredient (blue arrow). Radical cholecystectomy, partial liver resection, and regional lymphadenectomy were performed. Pathological examination indicated mixed adenoneuroendocrine carcinoma, with the following immunohistochemistry results: CD56 (+) (Figure 1F), Syn (+) (Figure 1G), CK19 (+) (Figure 1H), CgA (+), MLHL (+), PMS2 (+), MSH2 (+), MSH6 (+), Ki-67 (60%+).
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References
1. Zhang Z, Zhong D, Feng T, et al. Mixed Adenoneuroendocrine Carcinoma of the Gallbladder. J Gastrointest Surg 2022;26:503-506.
2. Wang H, Xu X, Wu Q, et al. Mixed adenoneuroendocrine carcinoma of the gallbladder with hepatic metastasis: A case report. Asian J Surg 2022;45:2155-2156.
3. Machairas N, Paspala A, Frountzas M, et al. Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management. In Vivo 2019;33:1721-1726.
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Wang Q, Li L, Li J, Fan W. Mixed adenoneuroendocrine carcinoma of the gallbladder. 9624/2023


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Publication history

Received: 27/03/2023

Accepted: 28/03/2023

Online First: 19/04/2023

Published: 11/01/2024

Article Online First time: 23 days

Article editing time: 290 days


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