Year 2021 / Volume 113 / Number 1
Original
Can inflammatory biomarkers help in the diagnosis and prognosis of gangrenous acute cholecystitis? A prospective study

41-44

DOI: 10.17235/reed.2020.7282/2020

José Ángel Díez Ares, Rosario Martínez García, Nuria Estellés Vidagany, Nuria Peris Tomás, Manuel Planells Roig, Marta Valenzuela Gras, Tomás Ripollés González,

Abstract
The diagnosis of gangrenous acute cholecystitis represents a diagnostic challenge for the physician and is rarely identified preoperatively. We report a longitudinal prospective study in 180 patients who underwent cholecystectomy for acute cholecystitis. A ROC curve was obtained to determine the preoperative cut-off for various biomarkers (neutrophil to lymphocyte ratio [NLR], C-reactive protein [CRP], platelet to lymphocyte ratio [PLR], lactate and procalcitonin) and their association with both preoperative and postoperative findings. The area under the curve (AUC) for NLR, CRP, PLR, lactate and procalcitonin was 0.75, 0.8, 0.65 and 0.6, respectively. NLR > 5 and CRP > 100 are still independent factors for gangrene (adjusted odds ratio [OR], 2 and 2.1, respectively).
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Díez Ares J, Martínez García R, Estellés Vidagany N, Peris Tomás N, Planells Roig M, Valenzuela Gras M, et all. Can inflammatory biomarkers help in the diagnosis and prognosis of gangrenous acute cholecystitis? A prospective study. 7282/2020


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Publication history

Received: 20/05/2020

Accepted: 27/05/2020

Online First: 15/10/2020

Published: 11/01/2021

Article revision time: 1 days

Article Online First time: 148 days

Article editing time: 236 days


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