Year 2016 / Volume 108 / Number 9
Letter to the Editor
Primary anorectal malignant melanoma: an uncommon anorectal pathology

604-605

DOI: 10.17235/reed.2016.4347/2016

José Francisco Juanmartiñena Fernández, Ignacio Fernández-Urien, Alicia Córdoba,

Abstract
Anorectal malignant melanoma (AMM) is most common primary melanoma of gastrointestinal tract, accounting for 0.05% and 1% of all colorectal and anal cancers. We reported an 85 year-old woman with no significant past medical history who presented two-month period of rectal bleeding, abdominal pain, tenesmus and 2kg weight-loss. Laboratory markers were unremarkable, although rectal examination revealed two small haemorrhoids and a firm, non-obstructing mass in the lower rectum. Colonoscopy confirmed presence of an ulcerated pigmented neoplasm arising at dental line [A,B]. No distant metastases were found on computed tomography [C] although presented metastatic regional lymph nodes on pelvic MRI [D]. Therefore, abdominoperineal resection was performed, confirming loco-regional disease. Histopathology showed malignant melanoma with positive stains in immunohistochemistry for protein S100, HMB-45 and Melan-A [E,F,G,H] and stained negative for c-Kit.
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References
1. Fernández M, Irarrázaval J, Larach A, et al. Melanoma anorrectal asociado a metástasis colónicas. Rev Esp Enferm Dig 2014; 106: 281-2.
2. Zhang S, Gao F, Wan D. Effect of misdiagnosis on the prognosis of anorectal malignant melanoma. J Cancer Res Clin Oncol.2010; 136:1401–5.
3. Duarte P, Ramos R, Vicente C., et al. Anal Melanoma with satellite implantations on the lower rectum. Rev Esp Enferm Dig 2011; 103:49-51.
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Juanmartiñena Fernández J, Fernández-Urien I, Córdoba A. Primary anorectal malignant melanoma: an uncommon anorectal pathology. 4347/2016


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Publication history

Received: 29/03/2016

Accepted: 31/03/2016

Online First: 08/04/2016

Published: 06/09/2016

Article Online First time: 10 days

Article editing time: 161 days


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