Year 2020 / Volume 112 / Number 1
Letter
Familial dysphagia: eosinophilic esophagitis

77-78

DOI: 10.17235/reed.2019.6610/2019

María del Mar Díaz Alcázar, Adelina García Robles, Francisco Javier Casado Caballero,

Abstract
We present a family with several cases of eosinophilic esophagitis. Some cases of eosinophilic esophagitis in the same family have been previously described. Patients with eosinophilic esophagitis present frequently atopy, and atopy has a strong family association due to complex interactions between genetic and environment. However, eosinophilic esophagitis has a stronger genetic component than other atopic diseases. Eosinophilic esophagitis has been linked to variations in genes like eotaxin-3, TSLP and its receptor and CAPN14, although the inheritance pattern has not yet well defined.
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References
1. Collins MH, Blanchard C, Abonia JP, et al. Clinical, pathological and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol 2008;6(6):621–9. Doi:10.1016/j.cgh.2008.01.004.
2. Holvoet S, Blanchard C. Genetic and molecular mechanisms leading to eosinophilic esophagitis. Rev Esp Enferm Dig 2014;106(4):276-80.
3. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004;113:11.
4. Walsh SV, Antonioli DA, Goldman H, et al. Allergic esophagitis in children. A clinicopathological entity. Am J Surg Pathol 1999;23:390–6.
5. Rothenberg ME. Eosinophilic esophagitis (EoE): genetics and immunopathogenesis. [Internet] Uptodate. [Last updated Aug 2018; access Feb 2019]. Available from: www.uptodate.com
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Díaz Alcázar M, García Robles A, Casado Caballero F. Familial dysphagia: eosinophilic esophagitis. 6610/2019


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Publication history

Received: 03/09/2019

Accepted: 13/09/2019

Online First: 07/01/2020

Published: 10/01/2020

Article Online First time: 126 days

Article editing time: 129 days


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