Year 2019 / Volume 111 / Number 2
Original
Clinicopathologic factors associated with recurrence and long-term survival in node-negative advanced gastric cancer patients

111-120

DOI: 10.17235/reed.2018.5829/2018

Bochao Zhao, Xinyu Huang, Jiale Zhang, Rui Luo, Huiwen Lu, Huimian Xu, Baojun Huang,

Abstract
Background: despite a better prognosis in node-negative advanced gastric cancer (GC), a proportion of patients have a tumor recurrence within five years and eventually die due to cancer-related causes. The present study aimed to evaluate the predictive factors of tumor recurrence and long-term survival in node-negative advanced GC. Methods: a total of 646 node-negative advanced GC patients who underwent a curative gastrectomy in our institution were included in the study. The impact of different clinicopathologic factors on tumor recurrence and overall survival were analyzed. Results: tumor recurrences were observed in 181 patients and the cumulative recurrence rate at two-years and five-years were 50.8% and 86.2%, respectively. Lymphovascular invasion, advanced T stage (T3-T4) and an inadequate number of retrieved lymph nodes (LNs) were independent predictive factors of tumor recurrence in node-negative advanced GC. Older age, an upper 1/3 tumor, lymphovascular invasion, infiltration growth pattern (INFγ) and the depth of tumor invasion (T4 stage) were independently associated with long-term survival. With regard to node-negative patients with ≥ 15 retrieved LNs, infiltration growth pattern (INFγ) and advanced T stage (T3-T4) were independent risk factors for both tumor recurrence and long-term survival. Conclusion: in addition to lymphovascular invasion, inadequate RLNs and advanced T stage, the prognostic significance of infiltration growth pattern in node-negative advanced GC was especially emphasized. These risk factors should be considered when selecting candidates for adjuvant chemotherapy and postoperative surveillance.
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Zhao B, Huang X, Zhang J, Luo R, Lu H, Xu H, et all. Clinicopathologic factors associated with recurrence and long-term survival in node-negative advanced gastric cancer patients. 5829/2018


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Publication history

Received: 14/07/2018

Accepted: 11/09/2018

Online First: 08/11/2018

Published: 01/02/2019

Article revision time: 56 days

Article Online First time: 117 days

Article editing time: 202 days


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