Year 2023 / Volume 115 / Number 7
Letter
Colon adenocarcinoma associated with intestinal sarcoidosis

398-399

DOI: 10.17235/reed.2022.9279/2022

Macarena Soto Dopazo, Carlos Joaquín Álvarez Laso, María Poch Arenas, José Carlos Fernández Fernández,

Abstract
Sarcoidosis is a multisystem chronic inflammatory disease of unknown etiology, characterized by non-caseating granulomas. Sarcoidosis has the potential to involve every tissue in the body, which mainly affect the lymphatic system and lungs; gastrointestinal system, and particularly the colon, is an extremely rare location. We report the case of a 64-year-old male with history of pulmonary and cutaneous sarcoidosis diagnosed with neoplasm in the hepatic flexure of the colon and a polyp with high-grade dysplasia in the transverse colon by colonoscopy after a positive fecal occult blood test. The case was presented to a multidisciplinary committee and it was decided to perform a total laparoscopic colectomy and ileorectal anastomosis with histopathological evidence of infiltrating adenocarcinoma and intestinal sarcoidosis with non-caseating granulomas in the appendix, terminal ileum, colon and locoregional lymph nodes. The relationship between colon cancer and sarcoidosis is controversial, with studies showing a possible increased risk of cancer in patients with sarcoidosis, relating it to the chronic proinflammatory state of the disease. In these cases, lymph node involvement is especially important when assessing tumor extension studies, and may lead to changes in staging and, as a consequence, in the therapeutic approach.
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References
1. Kataoka M, Nakata Y, Hioka T, et al. Malignancies in patients with sarcoidosis. Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Apr;30(4):598-603.
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Soto Dopazo M, Álvarez Laso C, Poch Arenas M, Fernández Fernández J. Colon adenocarcinoma associated with intestinal sarcoidosis. 9279/2022


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Publication history

Received: 12/10/2022

Accepted: 19/10/2022

Online First: 10/11/2022

Published: 06/07/2023

Article Online First time: 29 days

Article editing time: 267 days


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