Year 2025 / Volume 117 / Number 11
Letter
Isolated colonic amyloidosis: a rare condition mimicking malignancy

697-698

DOI: 10.17235/reed.2025.11100/2025

Macarena Torres-Larrubia, Sergio Casiano-Manzano, Zulianni Andreina Jiménez-Colmenárez, Joaquín Domínguez-Humanes, Alberto Masa-Caballero, María Herrador-Paredes, Pilar Mata-Romero, Pablo Solís-Muñoz,

Abstract
We report the case of a 54-year-old male with localized colonic amyloidosis presenting as rectal bleeding. Initial colonoscopy revealed a neoplastic-appearing lesion in the descending colon, but histopathology identified amyloid deposits, confirmed by Congo Red staining. Further assessment ruled out systemic involvement and primary (AL) amyloidosis, establishing the diagnosis as isolated colonic amyloidosis. This case highlights the importance of biopsy and histopathological evaluation in patients with atypical findings, especially when confounding factors such as monoclonal gammopathy of undetermined significance (MGUS) are present. Comprehensive pathological and molecular assessment are important to differentiate between localized and systemic amyloidosis and guide appropriate management.
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References
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2. Dahiya DS, Kichloo A, Singh J,et al. Gastrointestinal amyloidosis: A focused review. World J Gastrointest Endosc. 2021; 13(1): 1-12. DOI: 10.4253/wjge.v13.i1.1
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Torres-Larrubia M, Casiano-Manzano S, Jiménez-Colmenárez Z, Domínguez-Humanes J, Masa-Caballero A, Herrador-Paredes M, et all. Isolated colonic amyloidosis: a rare condition mimicking malignancy. 11100/2025


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Publication history

Received: 23/01/2025

Accepted: 06/03/2025

Online First: 27/03/2025

Published: 11/11/2025

Article Online First time: 63 days

Article editing time: 292 days


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