Year 2025 / Volume 117 / Number 8
Letter
Sudden onset of severe oral and gastrointestinal lesions in a patient with lung cancer

481-482

DOI: 10.17235/reed.2025.11408/2025

Cong Dai, Yu-Hong Huang,

Abstract
Severe oral and gastrointestinal mucositis, though rare with immune checkpoint inhibitors, represents a life-threatening immune-related adverse events (irAE) requiring prompt recognition1,2. Key diagnostic steps include ruling out infections and inflammatory bowel disease. Early high-dose corticosteroids are the cornerstone of therapy, with escalation to biologic agents in refractory cases. 
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References
1. Lederhandler MH, Ho A, Brinster N, et al. Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab. J Drugs Dermatol 2018; 17: 807-809.
2. Elad S, Yarom N, Zadik Y, et al. The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies. CA Cancer J Clin 2022; 72: 57-77.
3. Dai C, Huang YH. Treatment of steroid-refractory immune checkpoint inhibitor-induced intestinal pseudo-obstruction with infliximab. Rev Esp Enferm Dig. 2024; 116: 383-384.
1. Lederhandler MH, Ho A, Brinster N, et al. Severe Oral Mucositis: A Rare Adverse Event of Pembrolizumab. J Drugs Dermatol 2018; 17: 807-809.
2. Elad S, Yarom N, Zadik Y, et al. The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies. CA Cancer J Clin 2022; 72: 57-77.
3. Dai C, Huang YH. Treatment of steroid-refractory immune checkpoint inhibitor-induced intestinal pseudo-obstruction with infliximab. Rev Esp Enferm Dig. 2024; 116: 383-384.
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Dai C, Huang Y. Sudden onset of severe oral and gastrointestinal lesions in a patient with lung cancer . 11408/2025


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Publication history

Received: 11/06/2025

Accepted: 22/06/2025

Online First: 27/06/2025

Published: 24/07/2025

Article Online First time: 16 days

Article editing time: 43 days


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