Year 2014 / Volume 106 / Number 2
Letter to the Editor
Ulcerative colitis and isotretinoin: Is there a causal relationship?

150-151

Rogger álvaro Bendezú García, álvaro Hernández Martínez, Gustavo óliver Patrón Román, Francisco Bravo Castillo y José Luis Vega Sáenz

Abstract
Dear Editor,
We are reporting the case of a 39-year-old woman without toxic habits and with a history of mild mitral valve prolapsed that, after treatment of acne with dermatologist prescribed isotretinoin, consulted because of an increase in the number of bowel movements and bright red blood rectal bleeding after defecating without accompanying anal symptoms.
The analytical study was normal and a colonoscopy was per- formed. Signs of inflammation were found in the distal 10 cm of rectal mucosal and had an erythematous and granular appearance with effacement of the submucosal vascular pattern and non-confluent micro-ulcers. All of this is suggestive of ulcerative proctitis (Fig. 1). The histological study showed an alteration in the glandular architecture with a reduction of goblet cells without observing crypt abscesses and with dense inflammatory infiltrate of plasma cells in the lamina propria.
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Rogger álvaro Bendezú García, álvaro Hernández Martínez, Gustavo óliver Patrón Román, Francisco Bravo Castillo y José Luis Vega Sáenz. Ulcerative colitis and isotretinoin: Is there a causal relationship?. 150-151


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