Year 2023 / Volume 115 / Number 12
Letter
The role of gastrointestinal endoscopy in Kaposi sarcoma

724-725

DOI: 10.17235/reed.2023.9534/2023

Patricia Gonzalez-Ballesteros, José Guillermo de la Mora Levy, Edgardo Amaya-Fragoso, Beatriz Alejandra Sánchez Jíménez,

Abstract
We are writing to make endoscopists aware of the paramount of a prompt diagnosis of gastrointestinal Kaposi sarcoma (GI-KS). Patients with GI involvement have a two to five times higher risk of death and will benefit from chemotherapy to improve their survival. However, current evidence found that one out of three patients might have a false negative result even with HHV-8 since other entities such as gastrointestinal stromal tumors, angiosarcoma, and lymphoma shared macroscopic and histopathological characteristics. These cause a delay in treatment and significantly worsen the prognosis. We observed a trend for a positive diagnosis from ulcers and nodules. To our knowledge, this is the largest cohort of patients with GI-KS in the world. Our study suggests that in cases where a complete immunochemistry panel for KS is not available, HHV-8 remains as a bare minimum. However, other gastrointestinal lesions shared histopathological characteristics. Therefore, we suggest taking biopsies from nodular and ulcer-type lesions to increase the probability to establish a histopathological diagnosis.
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References
1. Rezende REF, Kahwage RL, da Costa TV, et al. Upper gastrointestinal Kaposi’s sarcoma in HIV-infected patients: ten years of endoscopy observation at a single Brazilian center. International Journal of Infectious Diseases.2015;39:110-5.
2. Cesarman E, Damania B, Krown SE, et al. Kaposi sarcoma. Nat Rev Dis Primers. 2019;5(1):9.
3. Busakhala N, Kigen G, Waako P, et al. Three year survival among patients with aids-related Kaposi sarcoma treated with chemotherapy and combination antiretroviral therapy at Moi teaching and referral hospital, Kenya. Infect Agents Cancer. 2019;14(1):24.
4. Carmo J, Chaves Marques S, Bispo M, et al. Clinical and Endoscopic Features of Gastrointestinal Kaposi Sarcoma: A Single-Center Portuguese Experience over the Last Decade. GE Port J Gastroenterol. 2017;24(5):219-26.
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Gonzalez-Ballesteros P, de la Mora Levy J, Amaya-Fragoso E, Sánchez Jíménez B. The role of gastrointestinal endoscopy in Kaposi sarcoma . 9534/2023


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Publication history

Received: 16/02/2023

Accepted: 21/02/2023

Online First: 03/03/2023

Published: 12/12/2023

Article Online First time: 15 days

Article editing time: 299 days


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